(Q46985701)

27 December 2017

title

Allosteric small molecules unveil a role of an extracellular E2/transmembrane helix 7 junction for G protein-coupled receptor activation (English)

1 reference

27 December 2017

G protein-coupled receptor

main subject

transmembrane protein

0 references

1 reference

9

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27 December 2017

Hans-Dieter Höltje

10

object named as

Hans-Dieter Höltje

1 reference

27 December 2017

Dorothea Jäger

1

1 reference

27 December 2017

Caroline Schmalenbach

2

1 reference

27 December 2017

Stefanie Prilla

3

1 reference

27 December 2017

Jasmin Schrobang

4

1 reference

27 December 2017

Anna Kebig

5

1 reference

27 December 2017

Matthias Sennwitz

6

1 reference

27 December 2017

Eberhard Heller

7

1 reference

27 December 2017

Christian Tränkle

8

1 reference

27 December 2017

Klaus Mohr

11

1 reference

27 December 2017

language of work or name

English

0 references

publication date

21 September 2007

1 reference

27 December 2017

Journal of Biological Chemistry

number of pages

9

1 reference

based on heuristic

inferred from page(s)

published in

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27 December 2017

volume

282

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27 December 2017

issue

48

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27 December 2017

page(s)

34968-34976

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27 December 2017

Uncovering molecular mechanisms involved in activation of G protein-coupled receptors

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1 reference

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Molecular mechanism of 7TM receptor activation--a global toggle switch model

21 January 2018

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The second extracellular loop of the dopamine D2 receptor lines the binding-site crevice

21 January 2018

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Essential role for the second extracellular loop in C5a receptor activation

21 January 2018

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Molecular characterization of a purified 5-HT4 receptor: a structural basis for drug efficacy

21 January 2018

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21 January 2018

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Allosteric binding sites on muscarinic acetylcholine receptors

21 January 2018

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Allosteric modulation of muscarinic receptor signaling: alcuronium-induced conversion of pilocarpine from an agonist into an antagonist

21 January 2018

1 reference

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Development of a new type of allosteric modulator of muscarinic receptors: hybrids of the antagonist AF-DX 384 and the hexamethonio derivative W84.

21 January 2018

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Muscarinic allosteric enhancers of ligand binding: pivotal pharmacophoric elements in hexamethonio-type agents

21 January 2018

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The retinal conformation and its environment in rhodopsin in light of a new 2.2 A crystal structure

21 January 2018

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Molecular recognition of receptor sites using a genetic algorithm with a description of desolvation

21 January 2018

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Allosteric site in M2 acetylcholine receptors: evidence for a major conformational change upon binding of an orthosteric agonist instead of an antagonist

21 January 2018

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Measurement of the millisecond activation switch of G protein-coupled receptors in living cells

21 January 2018

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Allosteric site on muscarinic acetylcholine receptors: a single amino acid in transmembrane region 7 is critical to the subtype selectivities of caracurine V derivatives and alkane-bisammonium ligands

21 January 2018

1 reference

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Allosteric site on muscarinic acetylcholine receptors: identification of two amino acids in the muscarinic M2 receptor that account entirely for the M2/M5 subtype selectivities of some structurally diverse allosteric ligands in N-methylscopolamine-o

21 January 2018

1 reference

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Allosteric agonists of 7TM receptors: expanding the pharmacological toolbox

21 January 2018

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Allosteric binding sites on cell-surface receptors: novel targets for drug discovery

21 January 2018

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Modes of allosteric interactions with free and [3H]N-methylscopolamine-occupied muscarinic M2 receptors as deduced from buffer-dependent potency shifts

21 January 2018

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Systematic development of high affinity bis(ammonio)alkane-type allosteric enhancers of muscarinic ligand binding

21 January 2018

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GROMACS 3.0: a package for molecular simulation and trajectory analysis

21 January 2018

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Critical Role for the Second Extracellular Loop in the Binding of Both Orthosteric and Allosteric G Protein-coupled Receptor Ligands

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M705563200

1 reference

27 December 2017

1 reference

27 December 2017