(Q47072494)

5 January 2018

title

JNK pathway mediates apoptotic cell death induced by tumor suppressor LKB1 in Drosophila (English)

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5 January 2018

main subject

Drosophila

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Lkb1 kinase Dmel_CG9374

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GOA release 2020-03-11

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Lee JH

1

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5 January 2018

Koh H

2

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5 January 2018

Kim M

3

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5 January 2018

Park J

4

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5 January 2018

Lee SY

5

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5 January 2018

Lee S

6

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5 January 2018

Chung J

7

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5 January 2018

publication date

4 November 2005

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5 January 2018

Cell Death & Differentiation

published in

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5 January 2018

volume

13

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5 January 2018

issue

7

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5 January 2018

page(s)

1110-1122

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5 January 2018

https://scigraph.springernature.com/pub.10.1038/sj.cdd.4401790

exact match

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Molecular genetic alterations in hamartomatous polyps and carcinomas of patients with Peutz-Jeghers syndrome

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Functional analysis of LKB1/STK11 mutants and two aberrant isoforms found in Peutz-Jeghers Syndrome patients.

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Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrest

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LKB1 associates with Brg1 and is necessary for Brg1-induced growth arrest

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Growth arrest by the LKB1 tumor suppressor: induction of p21(WAF1/CIP1).

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The LKB1 tumor suppressor negatively regulates mTOR signaling

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Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome

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The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death

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Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth

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Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD.

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Signal transduction by the JNK group of MAP kinases

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Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway

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The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development

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Reaper-mediated inhibition of DIAP1-induced DTRAF1 degradation results in activation of JNK in Drosophila.

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7 January 2021

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puckered encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in Drosophila

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7 January 2021

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7 January 2021

Identifiers

DOI

10.1038/SJ.CDD.4401790

1 reference

5 January 2018

1 reference

5 January 2018