(Q47268431)

13 January 2018

title

The role of size and charge for blood-brain barrier permeation of drugs and fatty acids (English)

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13 January 2018

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Anna Seelig

1

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13 January 2018

publication date

1 September 2007

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13 January 2018

Journal of Molecular Neuroscience

published in

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13 January 2018

volume

33

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13 January 2018

page(s)

32-41

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13 January 2018

issue

1

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13 January 2018

https://scigraph.springernature.com/pub.10.1007/s12031-007-0055-y

exact match

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cites work

Inhibitors of multidrug efflux transporters: their membrane and protein interactions

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https://api.crossref.org/works/10.1007%2FS12031-007-0055-Y

Unraveling membrane-mediated substrate-transporter interactions

21 January 2018

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Effect of endotoxin on doxorubicin transport across blood-brain barrier and P-glycoprotein function in mice

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Phase behavior and bilayer properties of fatty acids: hydrated 1:1 acid-soaps

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Structure-activity relationship of P-glycoprotein substrates and modifiers.

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Peptide binding to lipid bilayers. Nonclassical hydrophobic effect and membrane-induced pK shifts

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Substrate recognition by P-glycoprotein and the multidrug resistance-associated protein MRP1: a comparison.

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Halogenation of drugs enhances membrane binding and permeation

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Real-time monitoring of P-glycoprotein activation in living cells

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Lipid conformation in model membranes and biological membranes

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Predicting drug absorption: how nature made it a difficult problem.

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Functional role of P-glycoprotein in limiting intestinal absorption of drugs: contribution of passive permeability to P-glycoprotein mediated efflux transport

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A new model of weak acid permeation through membranes revisited: does Overton still rule?

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P-Glycoprotein kinetics measured in plasma membrane vesicles and living cells

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ABC transporters and the blood-brain barrier

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The ATP switch model for ABC transporters

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Quantification and characterization of P-glycoprotein-substrate interactions

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The rate of P-glycoprotein activation depends on the metabolic state of the cell

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12 December 2020

Blood-brain barrier permeation: molecular parameters governing passive diffusion

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Solute diffusion in lipid bilayer membranes: an atomic level study by molecular dynamics simulation

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Direct determination by 2H-NMR of the ionization state of phospholipids and of a local anaesthetic at the membrane surface.

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A novel electron paramagnetic resonance approach to determine the mechanism of drug transport by P-glycoprotein

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Local anesthetics and pressure: a comparison of dibucaine binding to lipid monolayers and bilayers

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How are free fatty acids transported in membranes? Is it by proteins or by free diffusion through the lipids?

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Drug-stimulatable ATPase activity in crude membranes of human MDR1-transfected mammalian cells

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Calcium receptor antagonists modify cocaine effects in the central nervous system differently.

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Effect of size and charge on the passive diffusion of peptides across Caco-2 cell monolayers via the paracellular pathway.

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Fatty acid transport: difficult or easy?

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Interaction of verapamil with lipid membranes and P-glycoprotein: connecting thermodynamics and membrane structure with functional activity

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A general pattern for substrate recognition by P-glycoprotein.

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In silico prediction of blood-brain barrier permeation using the calculated molecular cross-sectional area as main parameter

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pH gradients across phospholipid membranes caused by fast flip-flop of un-ionized fatty acids

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Structure-activity relationships of P-glycoprotein interacting drugs: kinetic characterization of their effects on ATPase activity

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Transition State Analysis of the Coupling of Drug Transport to ATP Hydrolysis by P-glycoprotein

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Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene.

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Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

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Studies with novel Pdr5p substrates demonstrate a strong size dependence for xenobiotic efflux

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A method to determine the ability of drugs to diffuse through the blood-brain barrier

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The role of the transporter P-glycoprotein for disposition and effects of centrally acting drugs and for the pathogenesis of CNS diseases

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Effect of monolayer surface pressure on the activities of phosphoinositide-specific phospholipase C-beta 1, -gamma 1, and -delta 1.

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ATPase activity of P-glycoprotein related to emergence of drug resistance in Ehrlich ascites tumor cell lines

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12 December 2020

10.1007/S12031-007-0055-Y

Identifiers

DOI

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13 January 2018

PubMed ID

17901543

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13 January 2018