(Q47273210)

13 January 2018

title

Distinct differences in prion-like seeding and aggregation between tau protein variants provide mechanistic insights into tauopathies (English)

1 reference

13 January 2018

0 references

Cara L Croft

2

0 references

author name string

Kevin H Strang

1

1 reference

13 January 2018

Zachary A Sorrentino

3

1 reference

13 January 2018

Paramita Chakrabarty

4

1 reference

13 January 2018

Todd E Golde

5

1 reference

13 January 2018

Benoit I Giasson

6

1 reference

13 January 2018

language of work or name

English

0 references

publication date

19 December 2017

1 reference

13 January 2018

Journal of Biological Chemistry

published in

1 reference

13 January 2018

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5818185/fullTextXML

inferred from PubMed Central ID database lookup

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26 August 2018

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26 August 2018

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26 August 2018

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26 August 2018

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26 August 2018

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26 August 2018

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Induction of intracellular tau aggregation is promoted by α-synuclein seeds and provides novel insights into the hyperphosphorylation of tau.

26 August 2018

1 reference

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Seeding of normal Tau by pathological Tau conformers drives pathogenesis of Alzheimer-like tangles

26 August 2018

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26 August 2018

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Residue Glu83 plays a major role in negatively regulating alpha-synuclein amyloid formation

26 August 2018

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26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5818185

Propagation of tau misfolding from the outside to the inside of a cell.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5818185

Structural polymorphism of 441-residue tau at single residue resolution

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5818185

Conformational diversity of wild-type Tau fibrils specified by templated conformation change

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5818185

Tau exon 10 alternative splicing and tauopathies

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5818185

Interaction of tau protein with the dynactin complex

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5818185

Prevention of amyloid-like aggregation as a driving force of protein evolution.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5818185

Knock-out and transgenic mouse models of tauopathies.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5818185

Insights into prion strains and neurotoxicity

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5818185

Stepwise proteolysis liberates tau fragments that nucleate the Alzheimer-like aggregation of full-length tau in a neuronal cell model

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5818185

Global hairpin folding of tau in solution

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5818185

Inducible expression of Tau repeat domain in cell models of tauopathy: aggregation is toxic to cells but can be reversed by inhibitor drugs

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5818185

Tau aggregation is driven by a transition from random coil to beta sheet structure

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5818185

Promotion of hyperphosphorylation by frontotemporal dementia tau mutations

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5818185

A comparison of amyloid fibrillogenesis using the novel fluorescent compound K114.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5818185

Initiation and Synergistic Fibrillization of Tau and Alpha-Synuclein

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5818185

Sequence conservation in Ig-like domains: the role of highly conserved proline residues in the fibronectin type III superfamily

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5818185

Selective deposition of mutant tau in the FTDP-17 brain affected by the P301L mutation.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5818185

Neurodegenerative tauopathies

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5818185

Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5818185

Missense and silent tau gene mutations cause frontotemporal dementia with parkinsonism-chromosome 17 type, by affecting multiple alternative RNA splicing regulatory elements

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5818185

Accelerated filament formation from tau protein with specific FTDP-17 missense mutations.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5818185

A nucleated assembly mechanism of Alzheimer paired helical filaments

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5818185

Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5818185

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5818185

Tau pathology in two Dutch families with mutations in the microtubule-binding region of tau

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5818185

Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5818185

Alzheimer-like changes in microtubule-associated protein Tau induced by sulfated glycosaminoglycans. Inhibition of microtubule binding, stimulation of phosphorylation, and filament assembly depend on the degree of sulfation.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5818185

Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5818185

Monoclonal antibody AT8 recognises tau protein phosphorylated at both serine 202 and threonine 205.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5818185

Functional implications for the microtubule-associated protein tau: localization in oligodendrocytes

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5818185

The distribution of tau in the mammalian central nervous system

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5818185

Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5818185

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5818185

A protein factor essential for microtubule assembly

26 August 2018

1 reference

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Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5818185

Tau proteins with FTDP-17 mutations have a reduced ability to promote microtubule assembly

26 August 2018

1 reference

12 December 2020

FTDP-17 mutations N279K and S305N in tau produce increased splicing of exon 10

1 reference

12 December 2020

Effects of frontotemporal dementia FTDP-17 mutations on heparin-induced assembly of tau filaments

1 reference

12 December 2020

Structure, microtubule interactions, and paired helical filament aggregation by tau mutants of frontotemporal dementias

1 reference

12 December 2020

Characterization of two VQIXXK motifs for tau fibrillization in vitro

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12 December 2020

Fibrillogenic nuclei composed of P301L mutant tau induce elongation of P301L tau but not wild-type tau

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M117.815357

1 reference

13 January 2018

PMC publication ID

5818185

0 references

1 reference

13 January 2018