(Q47326513)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29208682%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

title

The receptor tyrosine kinase EphA2 promotes glutamine metabolism in tumors by activating the transcriptional coactivators YAP and TAZ (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29208682%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29208682%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

Verra M. Ngwa

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29208682%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

Eileen Shiuan

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29208682%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

Albert B Reynolds

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29208682%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

Jin Chen

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29208682%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

author name string

Shan Wang

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29208682%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

Dana M Brantley-Sieders

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29208682%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

Laura C Kim

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29208682%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

publication date

5 December 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29208682%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29208682%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

volume

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29208682%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

issue

508

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29208682%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

5 April 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5819349/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth

26 August 2018

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26 August 2018

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Glutaminase 2 is a novel negative regulator of small GTPase Rac1 and mediates p53 function in suppressing metastasis.

26 August 2018

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A MYC-Driven Change in Mitochondrial Dynamics Limits YAP/TAZ Function in Mammary Epithelial Cells and Breast Cancer

26 August 2018

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Reactivation of p53 by a Cytoskeletal Sensor to Control the Balance Between DNA Damage and Tumor Dissemination

26 August 2018

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ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer.

26 August 2018

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Yes-associated protein 1 and transcriptional coactivator with PDZ-binding motif activate the mammalian target of rapamycin complex 1 pathway by regulating amino acid transporters in hepatocellular carcinoma

26 August 2018

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YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers

26 August 2018

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Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth

26 August 2018

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Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis.

26 August 2018

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Opposing activities of the Ras and Hippo pathways converge on regulation of YAP protein turnover

26 August 2018

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Potential Biomarker of L-type Amino Acid Transporter 1 in Breast Cancer Progression

26 August 2018

1 reference

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Glutaminase 2 negatively regulates the PI3K/AKT signaling and shows tumor suppression activity in human hepatocellular carcinoma

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

Expression of glutaminase is upregulated in colorectal cancer and of clinical significance

26 August 2018

1 reference

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Antitumor activity of the glutaminase inhibitor CB-839 in triple-negative breast cancer

26 August 2018

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The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment

26 August 2018

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Epigenetic silencing of glutaminase 2 in human liver and colon cancers

26 August 2018

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ErbB2 activation upregulates glutaminase 1 expression which promotes breast cancer cell proliferation

26 August 2018

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Glutamine and cancer: cell biology, physiology, and clinical opportunities

26 August 2018

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Knock-down of glutaminase 2 expression decreases glutathione, NADH, and sensitizes cervical cancer to ionizing radiation

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

A mechanical checkpoint controls multicellular growth through YAP/TAZ regulation by actin-processing factors.

26 August 2018

1 reference

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Activation of SNAT1/SLC38A1 in human breast cancer: correlation with p-Akt overexpression

26 August 2018

1 reference

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The Hippo pathway and human cancer.

26 August 2018

1 reference

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Regulation of Hippo pathway by mitogenic growth factors via phosphoinositide 3-kinase and phosphoinositide-dependent kinase-1

26 August 2018

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Involvement of EphA2-mediated tyrosine phosphorylation of Shp2 in Shp2-regulated activation of extracellular signal-regulated kinase.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

VAMP-associated protein B (VAPB) promotes breast tumor growth by modulation of Akt activity

26 August 2018

1 reference

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Regulation of the Hippo-YAP pathway by protease-activated receptors (PARs).

26 August 2018

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26 August 2018

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Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

Regulation of tumor initiation and metastatic progression by Eph receptor tyrosine kinases.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

Mitochondrial localization and structure-based phosphate activation mechanism of Glutaminase C with implications for cancer metabolism

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

An in vitro investigation of metabolically sensitive biomarkers in breast cancer progression

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

Yes-associated protein promotes tumour development in luminal epithelial derived breast cancer

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

TAZ antagonizes the WWP1-mediated KLF5 degradation and promotes breast cell proliferation and tumorigenesis

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

Eph/ephrin profiling in human breast cancer reveals significant associations between expression level and clinical outcome.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

Role of YAP/TAZ in mechanotransduction

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

AXL receptor kinase is a mediator of YAP-dependent oncogenic functions in hepatocellular carcinoma.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

Early detection of recurrent breast cancer using metabolite profiling

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

A molecular network for de novo generation of the apical surface and lumen

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

The hippo tumor pathway promotes TAZ degradation by phosphorylating a phosphodegron and recruiting the SCF{beta}-TrCP E3 ligase.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

Targeting mitochondrial glutaminase activity inhibits oncogenic transformation

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

Cell signaling by receptor tyrosine kinases

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

Glutamine addiction: a new therapeutic target in cancer

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

Eph receptors and ephrins in cancer: bidirectional signalling and beyond

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP)

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

Elevation of receptor tyrosine kinase EphA2 mediates resistance to trastuzumab therapy.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

EphA2 mediates ligand-dependent inhibition and ligand-independent promotion of cell migration and invasion via a reciprocal regulatory loop with Akt

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

TEADs mediate nuclear retention of TAZ to promote oncogenic transformation

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

ChIP-seq: using high-throughput sequencing to discover protein-DNA interactions

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

EphA2 reexpression prompts invasion of melanoma cells shifting from mesenchymal to amoeboid-like motility style

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

Triggering and amplification of insulin secretion by dimethyl alpha-ketoglutarate, a membrane permeable alpha-ketoglutarate analogue

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

Eph receptors in breast cancer: roles in tumor promotion and tumor suppression.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

TEAD mediates YAP-dependent gene induction and growth control

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

Combinatorial patterns of histone acetylations and methylations in the human genome

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

A role for TAZ in migration, invasion, and tumorigenesis of breast cancer cells

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

Redundant roles of Tead1 and Tead2 in notochord development and the regulation of cell proliferation and survival

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

Overexpression of EPHA2 receptor destabilizes adherens junctions via a RhoA-dependent mechanism.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

Elucidation of a universal size-control mechanism in Drosophila and mammals

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

High-resolution profiling of histone methylations in the human genome

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

Insights into transcription enhancer factor 1 (TEF-1) activity from the solution structure of the TEA domain

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

A conditional feedback loop regulates Ras activity through EphA2.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

Genes that mediate breast cancer metastasis to lung

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

ONCOMINE: a cancer microarray database and integrated data-mining platform

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

Overexpression of HER2 (erbB2) in human breast epithelial cells unmasks transforming growth factor beta-induced cell motility

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

Increased Malignancy of Neu-Induced Mammary Tumors Overexpressing Active Transforming Growth Factor β1

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

The glutamate/neutral amino acid transporter family SLC1: molecular, physiological and pharmacological aspects

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

Soluble Eph A receptors inhibit tumor angiogenesis and progression in vivo.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

Identification of two human glutaminase loci and tissue-specific expression of the two related genes.

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

Cloning and analysis of unique human glutaminase isoforms generated by tissue-specific alternative splicing

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

Cloning of the sodium-dependent, broad-scope, neutral amino acid transporter Bo from a human placental choriocarcinoma cell line

26 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819349

Taxol resistance in breast cancer cells is mediated by the hippo pathway component TAZ and its downstream transcriptional targets Cyr61 and CTGF

26 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29208682

12 December 2020

inferred from PubMed ID database lookup

Expression of glutamine metabolism-related proteins according to molecular subtype of breast cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29208682

12 December 2020

inferred from PubMed ID database lookup

Cancer anabolic metabolism inhibitors move into clinic

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29208682

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1126/SCISIGNAL.AAN4667

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29208682%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29208682%20AND%20SRC:MED&resulttype=core&format=json

5 April 2020

PubMed publication ID

29208682

1 reference