(Q38087215)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23467301%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

title

The Hippo pathway and human cancer (English)

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25 February 2020

1

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25 February 2020

David M Thomas

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23467301%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

author name string

Xiaomeng Zhang

series ordinal

2

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25 February 2020

language of work or name

English

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publication date

7 March 2013

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23467301%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

published in

Nature Reviews Cancer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23467301%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

volume

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23467301%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23467301%20AND%20SRC:MED&resulttype=core&format=json

25 February 2020

page(s)

246-257

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https://scigraph.springernature.com/pub.10.1038/nrc3458

25 February 2020

exact match

0 references

cites work

salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines

1 reference

The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation

31 March 2020

1 reference

Hippo signaling: growth control and beyond

31 March 2020

1 reference

The Salvador-Warts-Hippo pathway - an emerging tumour-suppressor network

31 March 2020

1 reference

The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis

31 March 2020

1 reference

Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway

31 March 2020

1 reference

The Salvador partner Hippo promotes apoptosis and cell-cycle exit in Drosophila.

31 March 2020

1 reference

hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts

31 March 2020

1 reference

Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila

31 March 2020

1 reference

The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP

31 March 2020

1 reference

Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control

31 March 2020

1 reference

Elucidation of a universal size-control mechanism in Drosophila and mammals

31 March 2020

1 reference

The YAP and TAZ transcription co-activators: key downstream effectors of the mammalian Hippo pathway

31 March 2020

1 reference

Upstream regulation of the hippo size control pathway

31 March 2020

1 reference

The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells

31 March 2020

1 reference

Lgl, aPKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms.

31 March 2020

1 reference

Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein Expanded

31 March 2020

1 reference

The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded

31 March 2020

1 reference

The apical-basal cell polarity determinant Crumbs regulates Hippo signaling in Drosophila

31 March 2020

1 reference

The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway.

31 March 2020

1 reference

Basolateral junctions utilize warts signaling to control epithelial-mesenchymal transition and proliferation crucial for migration and invasion of Drosophila ovarian epithelial cells

31 March 2020

1 reference

Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling

31 March 2020

1 reference

Fat cadherin modulates organ size in Drosophila via the Salvador/Warts/Hippo signaling pathway.

31 March 2020

1 reference

The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size.

31 March 2020

1 reference

The tumor-suppressor gene fat controls tissue growth upstream of expanded in the hippo signaling pathway.

31 March 2020

1 reference

Delineation of a Fat tumor suppressor pathway

31 March 2020

1 reference

YAP1 increases organ size and expands undifferentiated progenitor cells

31 March 2020

1 reference

Yap1 acts downstream of α-catenin to control epidermal proliferation

31 March 2020

1 reference

Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size

31 March 2020

1 reference

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

31 March 2020

1 reference

A kinase shRNA screen links LATS2 and the pRB tumor suppressor

31 March 2020

1 reference

A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization

31 March 2020

1 reference

Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon

31 March 2020

1 reference

Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis

31 March 2020

1 reference

The Hippo pathway transcriptional co-activator, YAP, is an ovarian cancer oncogene.

31 March 2020

1 reference

Pretherapy nuclear factor-kappaB status, chemoradiation resistance, and metastatic progression in esophageal carcinoma

31 March 2020

1 reference

Suppression of lung tumor formation by the regulatory subunit of ribonucleotide reductase.

31 March 2020

1 reference

Cancer stem cell definitions and terminology: the devil is in the details.

31 March 2020

1 reference

A change of strategy in the war on cancer.

31 March 2020

1 reference

Minutes: Mutants of Drosophila autonomously affecting cell division rate

31 March 2020

1 reference

New frontiers in cell competition

31 March 2020

1 reference

An increase in the expression of ribonucleotide reductase large subunit 1 is associated with gemcitabine resistance in non-small cell lung cancer cell lines

31 March 2020

1 reference

"Stemness": transcriptional profiling of embryonic and adult stem cells

31 March 2020

1 reference

Expression of Yes-associated protein in common solid tumors

31 March 2020

1 reference

The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation

31 March 2020

1 reference

TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal

31 March 2020

1 reference

TAZ, a transcriptional modulator of mesenchymal stem cell differentiation

31 March 2020

1 reference

Regulation of the Hippo pathway by cell architecture and mechanical signals

31 March 2020

1 reference

Wnt/Planar cell polarity signaling: a new paradigm for cancer therapy

31 March 2020

1 reference

Epithelial cell polarity, stem cells and cancer

31 March 2020

1 reference

Control of tumourigenesis by the Scribble/Dlg/Lgl polarity module

31 March 2020

1 reference

E-cadherin germline mutations in familial gastric cancer.

31 March 2020

1 reference

E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components.

31 March 2020

1 reference

Control of growth of mammalian cells in cell culture

31 March 2020

1 reference

NF2deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions

31 March 2020

1 reference

Matrix crosslinking forces tumor progression by enhancing integrin signaling

31 March 2020

1 reference

Role of YAP/TAZ in mechanotransduction

31 March 2020

1 reference

Hippo pathway regulation by cell morphology and stress fibers.

31 March 2020

1 reference

Modulating F-actin organization induces organ growth by affecting the Hippo pathway

31 March 2020

1 reference

Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila

31 March 2020

1 reference

A tense situation: forcing tumour progression

31 March 2020

1 reference

Anoikis resistance and tumor metastasis

31 March 2020

1 reference

Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors

31 March 2020

1 reference

LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker

31 March 2020

1 reference

Chronic inflammation, immune escape, and oncogenesis in the liver: a unique neighborhood for novel intersections

31 March 2020

1 reference

Warts and Yorkie Mediate Intestinal Regeneration by Influencing Stem Cell Proliferation

31 March 2020

1 reference

The Hippo pathway regulates intestinal stem cell proliferation during Drosophila adult midgut regeneration

31 March 2020

1 reference

The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration

31 March 2020

1 reference

The Salvador/Warts/Hippo pathway controls regenerative tissue growth in Drosophila melanogaster

31 March 2020

1 reference

Regulation of Hippo signaling by Jun kinase signaling during compensatory cell proliferation and regeneration, and in neoplastic tumors.

31 March 2020

1 reference

The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program

31 March 2020

1 reference

Hippo pathway effector Yap is an ovarian cancer oncogene

31 March 2020

1 reference

Yes-associated protein is an independent prognostic marker in hepatocellular carcinoma

31 March 2020

1 reference

Overexpression of yes-associated protein contributes to progression and poor prognosis of non-small-cell lung cancer

31 March 2020

1 reference

Neurofibromatosis 2 [Bilateral acoustic neurofibromatosis, central neurofibromatosis, NF2, neurofibromatosis type II].

31 March 2020

1 reference

Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach

31 March 2020

1 reference

Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction

31 March 2020

1 reference

Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene

31 March 2020

1 reference

Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver

31 March 2020

1 reference

Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression

31 March 2020

1 reference

Mst1 and Mst2 protein kinases restrain intestinal stem cell proliferation and colonic tumorigenesis by inhibition of Yes-associated protein (Yap) overabundance

31 March 2020

1 reference

Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers

31 March 2020

1 reference

Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma

31 March 2020

1 reference

Frequent hypermethylation of MST1 and MST2 in soft tissue sarcoma

31 March 2020

1 reference

Identification of a disease-defining gene fusion in epithelioid hemangioendothelioma

31 March 2020

1 reference

A novel WWTR1-CAMTA1 gene fusion is a consistent abnormality in epithelioid hemangioendothelioma of different anatomic sites

31 March 2020

1 reference

Integration of intercellular signaling through the Hippo pathway

31 March 2020

1 reference

Dysregulation of Wnt/β-catenin signaling in gastrointestinal cancers

31 March 2020

1 reference

Tgf-beta signaling alterations and colon cancer

31 March 2020

1 reference

Targeting the hedgehog pathway: role in cancer and clinical implications of its inhibition

31 March 2020

1 reference

Oncogenic and tumor suppressor functions of Notch in cancer: it's NOTCH what you think.

31 March 2020

1 reference

A molecular mechanism that links Hippo signalling to the inhibition of Wnt/β-catenin signalling

31 March 2020

1 reference

Wnt/β-catenin signaling regulates Yes-associated protein (YAP) gene expression in colorectal carcinoma cells

31 March 2020

1 reference

Identification of Serum-Derived Sphingosine-1-Phosphate as a Small Molecule Regulator of YAP

31 March 2020

1 reference

The absence of LPA2 attenuates tumor formation in an experimental model of colitis-associated cancer

31 March 2020

1 reference

Oncogenic mutations in GNAQ occur early in uveal melanoma

31 March 2020

1 reference

Exon capture analysis of G protein-coupled receptors identifies activating mutations in GRM3 in melanoma.

31 March 2020

1 reference

Diverse somatic mutation patterns and pathway alterations in human cancers

31 March 2020

1 reference

Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi

31 March 2020

1 reference

Regulation of p53 activity by HIPK2: molecular mechanisms and therapeutical implications in human cancer cells.

31 March 2020

1 reference

Homeodomain-interacting protein kinase regulates Hippo pathway-dependent tissue growth

31 March 2020

1 reference

Homeodomain-interacting protein kinase regulates Yorkie activity to promote tissue growth

31 March 2020

1 reference

The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals

31 March 2020

1 reference

Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP

31 March 2020

1 reference

Photodynamic therapy with verteporfin: a new treatment in ophthalmology

31 March 2020

1 reference

Photodynamic therapy of cancer: an update

31 March 2020

1 reference

Regulator of G protein signaling proteins as drug targets: current state and future possibilities

31 March 2020

1 reference

A cell-based assay to screen stimulators of the Hippo pathway reveals the inhibitory effect of dobutamine on the YAP-dependent gene transcription

31 March 2020

1 reference

Targeting the lipids LPA and S1P and their signalling pathways to inhibit tumour progression

31 March 2020

1 reference

Biochemical and Structural Characterization of Lysophosphatidic Acid Binding by a Humanized Monoclonal Antibody

31 March 2020

1 reference

The crystal structure of sphingosine-1-phosphate in complex with a Fab fragment reveals metal bridging of an antibody and its antigen

31 March 2020

1 reference

Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis.

31 March 2020

1 reference

Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production

31 March 2020

1 reference

Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid.

31 March 2020

1 reference

An oncogenic role of sphingosine kinase

31 March 2020

1 reference

Sphingosine kinase-1 expression correlates with poor survival of patients with glioblastoma multiforme: roles of sphingosine kinase isoforms in growth of glioblastoma cell lines

31 March 2020

1 reference

Phase I and pharmacokinetic study of weekly NV06 (Phenoxodiol), a novel isoflav-3-ene, in patients with advanced cancer

31 March 2020

1 reference

Phase II evaluation of phenoxodiol in combination with cisplatin or paclitaxel in women with platinum/taxane-refractory/resistant epithelial ovarian, fallopian tube, or primary peritoneal cancers

31 March 2020

1 reference

YAP: at the crossroad between transformation and tumor suppression

31 March 2020

1 reference

Notch and disease: a growing field

31 March 2020

1 reference

Alterations in the Smad pathway in human cancers

31 March 2020

1 reference

Restriction of intestinal stem cell expansion and the regenerative response by YAP.

31 March 2020

1 reference

A mouse model recapitulating molecular features of human mesothelioma

31 March 2020

1 reference

Nf2 gene inactivation in arachnoidal cells is rate-limiting for meningioma development in the mouse

31 March 2020

1 reference

Aberrant epithelial morphology and persistent epidermal growth factor receptor signaling in a mouse model of renal carcinoma

31 March 2020

1 reference

Nf2/Merlin controls progenitor homeostasis and tumorigenesis in the liver

31 March 2020

1 reference

Mammalian sterile 20-like kinase 1 suppresses lymphoma development by promoting faithful chromosome segregation.

31 March 2020

1 reference

The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis.

31 March 2020

1 reference

Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice

31 March 2020

1 reference

The Hippo pathway regulates Wnt/beta-catenin signaling

31 March 2020

1 reference

Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways

31 March 2020

1 reference

YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation

31 March 2020

1 reference

YAP mediates crosstalk between the Hippo and PI(3)K–TOR pathways by suppressing PTEN via miR-29

31 March 2020

1 reference

Salvador-warts-hippo signaling promotes Drosophila posterior follicle cell maturation downstream of notch

31 March 2020

1 reference

Conditional biallelic Nf2 mutation in the mouse promotes manifestations of human neurofibromatosis type 2.

31 March 2020

1 reference

12 December 2020

Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate

1 reference

12 December 2020

Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein

1 reference

12 December 2020

Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase

1 reference

12 December 2020