(Q37968480)

26 August 2017

Epithelial cell polarity, stem cells and cancer (English)

1 reference

26 August 2017

2

1 reference

26 August 2017

Fernando Martin-Belmonte

series ordinal

1

1 reference

PubMed ID

22169974

26 August 2017

language of work or name

English

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publication date

15 December 2011

1 reference

26 August 2017

Nature Reviews Cancer

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26 August 2017

12

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26 August 2017

23-38

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26 August 2017

1

1 reference

https://scigraph.springernature.com/pub.10.1038/nrc3169

26 August 2017

0 references

cites work

Hallmarks of Cancer: The Next Generation

1 reference

Cell polarity in eggs and epithelia: parallels and diversity

21 January 2018

1 reference

Planar cell polarity signaling: from fly development to human disease

21 January 2018

1 reference

Organelle positioning and cell polarity

21 January 2018

1 reference

Regulation of asymmetric cell division in the epidermis

21 January 2018

1 reference

Sticky business: orchestrating cellular signals at adherens junctions

21 January 2018

1 reference

Regulation of cell polarity during epithelial morphogenesis

21 January 2018

1 reference

Cell polarity and cancer--cell and tissue polarity as a non-canonical tumor suppressor.

21 January 2018

1 reference

Integrins and cadherins join forces to form adhesive networks

21 January 2018

1 reference

The roles of nectins in cell adhesions: cooperation with other cell adhesion molecules and growth factor receptors

21 January 2018

1 reference

Mechanisms of epithelial cell-cell adhesion and cell compaction revealed by high-resolution tracking of E-cadherin-green fluorescent protein

21 January 2018

1 reference

Directed actin polymerization is the driving force for epithelial cell-cell adhesion

21 January 2018

1 reference

Roles of ZO-1 and ZO-2 in establishment of the belt-like adherens and tight junctions with paracellular permselective barrier function.

21 January 2018

1 reference

Regulation of cell-cell junctions by the cytoskeleton.

21 January 2018

1 reference

Cell-cell contact: cooperating clusters of actin and cadherin.

21 January 2018

1 reference

Par-3 controls tight junction assembly through the Rac exchange factor Tiam1.

21 January 2018

1 reference

The Rac activator Tiam1 controls tight junction biogenesis in keratinocytes through binding to and activation of the Par polarity complex

21 January 2018

1 reference

Widely conserved signaling pathways in the establishment of cell polarity

21 January 2018

1 reference

Interaction between PAR-3 and the aPKC-PAR-6 complex is indispensable for apical domain development of epithelial cells.

21 January 2018

1 reference

aPKC phosphorylation of Bazooka defines the apical/lateral border in Drosophila epithelial cells

21 January 2018

1 reference

Crumbs/DaPKC-dependent apical exclusion of Bazooka promotes photoreceptor polarity remodeling

21 January 2018

1 reference

DaPKC-dependent phosphorylation of Crumbs is required for epithelial cell polarity in Drosophila.

21 January 2018

1 reference

Formation of a Bazooka-Stardust complex is essential for plasma membrane polarity in epithelia

21 January 2018

1 reference

Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors.

21 January 2018

1 reference

Human homolog of disc-large is required for adherens junction assembly and differentiation of human intestinal epithelial cells

21 January 2018

1 reference

Junctional recruitment of mammalian Scribble relies on E-cadherin engagement

21 January 2018

1 reference

Mammalian Lgl Forms a Protein Complex with PAR-6 and aPKC Independently of PAR-3 to Regulate Epithelial Cell Polarity

21 January 2018

1 reference

Drosophila PAR-1 and 14-3-3 inhibit Bazooka/PAR-3 to establish complementary cortical domains in polarized cells

21 January 2018

1 reference

Role of Lgl/Dlg/Scribble in the regulation of epithelial junction, polarity and growth

21 January 2018

1 reference

Organizing the cell cortex: the role of ERM proteins

21 January 2018

1 reference

The NF2 tumor suppressor, Merlin, regulates epidermal development through the establishment of a junctional polarity complex

21 January 2018

1 reference

A tight junction-associated Merlin-angiomotin complex mediates Merlin's regulation of mitogenic signaling and tumor suppressive functions

21 January 2018

1 reference

Cadherins and cancer: how does cadherin dysfunction promote tumor progression?

21 January 2018

1 reference

Role of tight junctions in cell proliferation and cancer

21 January 2018

1 reference

The Claudin family and its role in cancer and metastasis

21 January 2018

1 reference

Nf2/Merlin controls progenitor homeostasis and tumorigenesis in the liver

21 January 2018

1 reference

The epithelial polarity program: machineries involved and their hijacking by cancer.

21 January 2018

1 reference

Epithelial cell polarity and tumorigenesis: new perspectives for cancer detection and treatment

21 January 2018

1 reference

Polarity protein alterations in carcinoma: a focus on emerging roles for polarity regulators

21 January 2018

1 reference

Transcriptional regulation of cell polarity in EMT and cancer

21 January 2018

1 reference

scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila

21 January 2018

1 reference

A Genetic Screen in Drosophila for Metastatic Behavior

21 January 2018

1 reference

Interaction between Ras(V12) and scribbled clones induces tumour growth and invasion

21 January 2018

1 reference

Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma

21 January 2018

1 reference

Polarity proteins in migration and invasion

21 January 2018

1 reference

Polarity regulators and the control of epithelial architecture, cell migration, and tumorigenesis.

21 January 2018

1 reference

Loss of human Scribble cooperates with H-Ras to promote cell invasion through deregulation of MAPK signalling

21 January 2018

1 reference

The cell polarity regulator hScrib controls ERK activation through a KIM site-dependent interaction

21 January 2018

1 reference

The transcription factor ZEB1 (deltaEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity

21 January 2018

1 reference

Expression of Dickkopf genes is strongly reduced in malignant melanoma

21 January 2018

1 reference

Lgl2 executes its function as a tumor suppressor by regulating ErbB signaling in the zebrafish epidermis

21 January 2018

1 reference

Aberrant splicing of Hugl-1 is associated with hepatocellular carcinoma progression

21 January 2018

1 reference

Role of the polarity determinant crumbs in suppressing mammalian epithelial tumor progression

21 January 2018

1 reference

Cell polarity in development and cancer.

21 January 2018

1 reference

ErbB receptors and signaling pathways in cancer

21 January 2018

1 reference

Par6-aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control

21 January 2018

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The polarity protein Par6 induces cell proliferation and is overexpressed in breast cancer

21 January 2018

1 reference

Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity

21 January 2018

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Transforming growth factor-beta-stimulated endocardial cell transformation is dependent on Par6c regulation of RhoA.

21 January 2018

1 reference

EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer

21 January 2018

1 reference

Protein kinase Cι expression and oncogenic signaling mechanisms in cancer.

21 January 2018

1 reference

Protein kinase Ciota is required for Ras transformation and colon carcinogenesis in vivo

21 January 2018

1 reference

Atypical protein kinase C iota is an oncogene in human non-small cell lung cancer

21 January 2018

1 reference

Identification of novel Ras-cooperating oncogenes in Drosophila melanogaster: a RhoGEF/Rho-family/JNK pathway is a central driver of tumorigenesis

21 January 2018

1 reference

The Hippo pathway and apico-basal cell polarity

21 January 2018

1 reference

The hippo signaling pathway in development and cancer

21 January 2018

1 reference

The Salvador-Warts-Hippo pathway - an emerging tumour-suppressor network

21 January 2018

1 reference

Lgl/aPKC and Crb regulate the Salvador/Warts/Hippo pathway

21 January 2018

1 reference

Basolateral junctions utilize warts signaling to control epithelial-mesenchymal transition and proliferation crucial for migration and invasion of Drosophila ovarian epithelial cells

21 January 2018

1 reference

Lgl, aPKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms.

21 January 2018

1 reference

Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein Expanded

21 January 2018

1 reference

The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway.

21 January 2018

1 reference

The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal

21 January 2018

1 reference

Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling.

21 January 2018

1 reference

The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program

21 January 2018

1 reference

The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration

21 January 2018

1 reference

Amphiregulin promotes intestinal epithelial regeneration: roles of intestinal subepithelial myofibroblasts

21 January 2018

1 reference

The Hippo pathway regulates intestinal stem cell proliferation during Drosophila adult midgut regeneration

21 January 2018

1 reference

Warts and Yorkie mediate intestinal regeneration by influencing stem cell proliferation

21 January 2018

1 reference

The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded

21 January 2018

1 reference

The apical-basal cell polarity determinant Crumbs regulates Hippo signaling in Drosophila

21 January 2018

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E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components.

21 January 2018

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Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size

21 January 2018

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Yap1 acts downstream of α-catenin to control epidermal proliferation

21 January 2018

1 reference

Frequent hypermethylation of MST1 and MST2 in soft tissue sarcoma

21 January 2018

1 reference

Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers

21 January 2018

1 reference

Shedding light on Merlin's wizardry

21 January 2018

1 reference

The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44

21 January 2018

1 reference

Membrane organization and tumorigenesis--the NF2 tumor suppressor, Merlin

21 January 2018

1 reference

The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals

21 January 2018

1 reference

The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis.

21 January 2018

1 reference

Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver

21 January 2018

1 reference

LKB1 and AMPK in cell polarity and division

21 January 2018

1 reference

A serine/threonine kinase gene defective in Peutz-Jeghers syndrome

21 January 2018

1 reference

A role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndrome

21 January 2018

1 reference

Somatic LKB1 mutations promote cervical cancer progression

21 January 2018

1 reference

Up-regulation of AMP-activated protein kinase in cancer cell lines is mediated through c-Src activation

21 January 2018

1 reference

LKB1 haploinsufficiency cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrest

21 January 2018

1 reference

Suppression of oncogenic properties of c-Myc by LKB1-controlled epithelial organization

21 January 2018

1 reference

The LKB1-AMPK pathway: metabolism and growth control in tumour suppression

21 January 2018

1 reference

A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity

21 January 2018

1 reference

Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD.

21 January 2018

1 reference

The LKB1/AMPK polarity pathway

21 January 2018

1 reference

Energy-dependent regulation of cell structure by AMP-activated protein kinase

21 January 2018

1 reference

LKB1 and AMPK maintain epithelial cell polarity under energetic stress

21 January 2018

1 reference

AMP-activated protein kinase regulates the assembly of epithelial tight junctions

21 January 2018

1 reference

Regulation of epithelial tight junction assembly and disassembly by AMP-activated protein kinase

21 January 2018

1 reference

The Ca2+/calmodulin-dependent protein kinase kinases are AMP-activated protein kinase kinases

21 January 2018

1 reference

Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells.

21 January 2018

1 reference

Regulation of LKB1/STRAD localization and function by E-cadherin

21 January 2018

1 reference

Differential requirements for STRAD in LKB1-dependent functions in C. elegans.

21 January 2018

1 reference

Lymphocytes accelerate epithelial tight junction assembly: role of AMP-activated protein kinase (AMPK)

21 January 2018

1 reference

Regulation of bile canalicular network formation and maintenance by AMP-activated protein kinase and LKB1.

21 January 2018

1 reference

Bile acid stimulates hepatocyte polarization through a cAMP-Epac-MEK-LKB1-AMPK pathway

21 January 2018

1 reference

Defining the role of mTOR in cancer

21 January 2018

1 reference

Dysfunctional AMPK activity, signalling through mTOR and survival in response to energetic stress in LKB1-deficient lung cancer.

21 January 2018

1 reference

mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome

21 January 2018

1 reference

Myosin light chains are not a physiological substrate of AMPK in the control of cell structure changes

21 January 2018

1 reference

Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex

21 January 2018

1 reference

The active form of the metabolic sensor: AMP-activated protein kinase (AMPK) directly binds the mitotic apparatus and travels from centrosomes to the spindle midzone during mitosis and cytokinesis.

21 January 2018

1 reference

Primary cilia regulate mTORC1 activity and cell size through Lkb1.

21 January 2018

1 reference

Epithelial stem cells: turning over new leaves

21 January 2018

1 reference

Asymmetric cell division: recent developments and their implications for tumour biology

21 January 2018

1 reference

Asymmetric cell divisions promote stratification and differentiation of mammalian skin

21 January 2018

1 reference

Robust control of mitotic spindle orientation in the developing epidermis

21 January 2018

1 reference

Developmental roles for Srf, cortical cytoskeleton and cell shape in epidermal spindle orientation

21 January 2018

1 reference

Asymmetric cell divisions promote Notch-dependent epidermal differentiation

21 January 2018

1 reference

Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue.

21 January 2018

1 reference

The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells.

21 January 2018

1 reference

Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium

21 January 2018

1 reference

Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells

21 January 2018

1 reference

Intestinal stem cell replacement follows a pattern of neutral drift

21 January 2018

1 reference

Cells of origin in cancer

21 January 2018

1 reference

The cancer stem cell: premises, promises and challenges

21 January 2018

1 reference

Concise review: polarity in stem cells, disease, and aging.

21 January 2018

1 reference

Aurora A, centrosome structure, and the centrosome cycle

21 January 2018

1 reference

Drosophila neuroblasts retain the daughter centrosome.

21 January 2018

1 reference

Functionally unequal centrosomes drive spindle orientation in asymmetrically dividing Drosophila neural stem cells.

21 January 2018

1 reference

Asymmetric inheritance of mother versus daughter centrosome in stem cell division

21 January 2018

1 reference

Asymmetric centrosome inheritance maintains neural progenitors in the neocortex

21 January 2018

1 reference

Linking cell cycle to asymmetric division: Aurora-A phosphorylates the Par complex to regulate Numb localization

21 January 2018

1 reference

Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles

21 January 2018

1 reference

Microtubule-induced Pins/Galphai cortical polarity in Drosophila neuroblasts.

21 January 2018

1 reference

The interphase microtubule aster is a determinant of asymmetric division orientation in Drosophila neuroblasts

21 January 2018

1 reference

LGN regulates mitotic spindle orientation during epithelial morphogenesis

21 January 2018

1 reference

From cells to organs: building polarized tissue.

21 January 2018

1 reference

Cdc42 controls spindle orientation to position the apical surface during epithelial morphogenesis

21 January 2018

1 reference

Par6B and atypical PKC regulate mitotic spindle orientation during epithelial morphogenesis

21 January 2018

1 reference

The Cdc42 GEF Intersectin 2 controls mitotic spindle orientation to form the lumen during epithelial morphogenesis.

21 January 2018

1 reference

Par3 controls epithelial spindle orientation by aPKC-mediated phosphorylation of apical Pins

21 January 2018

1 reference

Tuba, a Cdc42 GEF, is required for polarized spindle orientation during epithelial cyst formation

21 January 2018

1 reference

Canonical notch signaling functions as a commitment switch in the epidermal lineage

21 January 2018

1 reference

Spindle orientation, asymmetric division and tumour suppression in Drosophila stem cells

21 January 2018

1 reference

Tumor suppressor interactions with microtubules: keeping cell polarity and cell division on track

21 January 2018

1 reference

LKB1/PAR4 protein is asymmetrically localized in mouse oocytes and associates with meiotic spindle.

21 January 2018

1 reference

The Drosophila Lkb1 kinase is required for spindle formation and asymmetric neuroblast division.

21 January 2018

1 reference

VHL loss causes spindle misorientation and chromosome instability.

21 January 2018

1 reference

Mitotic spindle misorientation in cancer--out of alignment and into the fire.

21 January 2018

1 reference

Classical cadherins control nucleus and centrosome position and cell polarity

21 January 2018

1 reference

Cell polarity triggered by cell-cell adhesion via E-cadherin

21 January 2018

1 reference

Cadherin adhesion receptors orient the mitotic spindle during symmetric cell division in mammalian epithelia

21 January 2018

1 reference

Dynein binds to beta-catenin and may tether microtubules at adherens junctions.

21 January 2018

1 reference

Epicardial spindle orientation controls cell entry into the myocardium

21 January 2018

1 reference

beta-Catenin is a Nek2 substrate involved in centrosome separation

21 January 2018

1 reference

Drosophila E-cadherin regulates the orientation of asymmetric cell division in the sensory organ lineage

21 January 2018

1 reference

E-cadherin is required for centrosome and spindle orientation in Drosophila male germline stem cells

21 January 2018

1 reference

Adherens junction: molecular architecture and regulation

21 January 2018

1 reference

Cyclin-dependent kinase 2/cyclin E complex is involved in p120 catenin (p120ctn)-dependent cell growth control: a new role for p120ctn in cancer.

21 January 2018

1 reference

Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis

21 January 2018

1 reference

Adherens junctions inhibit asymmetric division in the Drosophila epithelium

21 January 2018

1 reference

Adenomatous polyposis coli (APC) is required for normal development of skin and thymus

21 January 2018

1 reference

Crypt stem cells as the cells-of-origin of intestinal cancer

21 January 2018

1 reference

Spindle misorientation in tumors from APC(min/+) mice.

21 January 2018

1 reference

Repression of mammary stem/progenitor cells by p53 is mediated by Notch and separable from apoptotic activity

21 January 2018

1 reference

A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity

21 January 2018

1 reference

Molecular components of the adherens junction.

21 January 2018

1 reference

Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly.

21 January 2018

1 reference

Tight junction and polarity interaction in the transporting epithelial phenotype.

21 January 2018

1 reference

Tight junction-based epithelial microenvironment and cell proliferation

21 January 2018

1 reference

Polarity complex proteins

21 January 2018

1 reference

The Crumbs complex: from epithelial-cell polarity to retinal degeneration

21 January 2018

1 reference

The PAR-aPKC system: lessons in polarity

21 January 2018

1 reference

The PAR proteins: fundamental players in animal cell polarization

21 January 2018

1 reference

Control of tumourigenesis by the Scribble/Dlg/Lgl polarity module

21 January 2018

1 reference

Polarity proteins regulate mammalian cell-cell junctions and cancer pathogenesis

21 January 2018

1 reference

Elucidation of a universal size-control mechanism in Drosophila and mammals

21 January 2018

1 reference

Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control

21 January 2018

1 reference

SCALLOPED interacts with YORKIE, the nuclear effector of the hippo tumor-suppressor pathway in Drosophila

21 January 2018

1 reference

The TEAD/TEF family protein Scalloped mediates transcriptional output of the Hippo growth-regulatory pathway.

21 January 2018

1 reference

The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control

21 January 2018

1 reference

The Drosophila RASSF homolog antagonizes the hippo pathway

21 January 2018

1 reference

The RASSF1A tumor suppressor

21 January 2018

1 reference

The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis

21 January 2018

1 reference

Cell polarity: Nailing Crumbs to the scaffold

21 January 2018

1 reference

Par1b promotes hepatic-type lumen polarity in Madin Darby canine kidney cells via myosin II- and E-cadherin-dependent signaling

21 January 2018

1 reference

MARK2/EMK1/Par-1Balpha phosphorylation of Rab11-family interacting protein 2 is necessary for the timely establishment of polarity in Madin-Darby canine kidney cells

21 January 2018

1 reference

Distinct PAR-1 proteins function in different branches of Wnt signaling during vertebrate development.

21 January 2018

1 reference

Megaintestine in claudin-15-deficient mice

21 January 2018

1 reference

Cooperative roles of Par-3 and afadin in the formation of adherens and tight junctions

31 March 2020

1 reference

The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer

31 March 2020

1 reference

Expression of Hugl-1 is strongly reduced in malignant melanoma

31 March 2020

1 reference

Identification of genes required for cytoplasmic localization in early C. elegans embryos

31 March 2020

1 reference

The role of APC in mitosis and in chromosome instability.

31 March 2020

1 reference

The RASSF proteins in cancer; from epigenetic silencing to functional characterization

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22169974

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22169974

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRC3169

1 reference

release_fcdgun2c4fhdtlnqcniymg2rrq

26 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/fcdgun2c4fhdtlnqcniymg2rrq

mapped directly with Wikidata item

24 November 2022

based on heuristic

PubMed ID

22169974

1 reference

PubMed ID

22169974