(Q47332836)

14 January 2018

title

Pyrin Inflammasome Regulates Tight Junction Integrity to Restrict Colitis and Tumorigenesis (English)

1 reference

14 January 2018

Thirumala-Devi Kanneganti

1 reference

1 reference

Peter Vogel

5

0 references

object named as

Thirumala-Devi Kanneganti

6

0 references

author name string

Deepika Sharma

1

1 reference

14 January 2018

Ankit Malik

2

1 reference

14 January 2018

Clifford S Guy

3

1 reference

14 January 2018

Rajendra Karki

4

1 reference

14 January 2018

language of work or name

English

0 references

publication date

1 December 2017

1 reference

14 January 2018

published in

Gastroenterology

1 reference

14 January 2018

Establishment of 3D Intestinal Organoid Cultures from Intestinal Stem Cells.

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NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer

29 September 2018

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Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation

29 September 2018

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Organoids as a Model for Colorectal Cancer

29 September 2018

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29 September 2018

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Nod1 Limits Colitis-Associated Tumorigenesis by Regulating IFN-γ Production

29 September 2018

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Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer

29 September 2018

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Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis

29 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5847456

Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling.

29 September 2018

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NLRP3 rs35829419 polymorphism is associated with increased susceptibility to multiple diseases in humans

29 September 2018

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Interleukin-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability

29 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5847456

Protective Role of β-arrestin2 in Colitis Through Modulation of T-cell Activation.

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5847456

Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt

29 September 2018

1 reference

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Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer

29 September 2018

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The NLRP1 inflammasome attenuates colitis and colitis-associated tumorigenesis

29 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5847456

Intestinal deletion of Claudin-7 enhances paracellular organic solute flux and initiates colonic inflammation in mice.

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5847456

New strategies for treatment of inflammatory bowel disease

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5847456

Interleukin-22 induces interleukin-18 expression from epithelial cells during intestinal infection

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5847456

Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5847456

The IL18RAP region disease polymorphism decreases IL-18RAP/IL-18R1/IL-1R1 expression and signaling through innate receptor-initiated pathways

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5847456

Targeted colonic claudin-2 expression renders resistance to epithelial injury, induces immune suppression, and protects from colitis.

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5847456

NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5847456

Contrasting immune responses mediate Campylobacter jejuni-induced colitis and autoimmunity

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5847456

In vitro organoid culture of primary mouse colon tumors

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5847456

Microbiota-induced activation of epithelial IL-6 signaling links inflammasome-driven inflammation with transmissible cancer

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5847456

TNFR2 activates MLCK-dependent tight junction dysregulation to cause apoptosis-mediated barrier loss and experimental colitis.

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5847456

Whole genome gene expression meta-analysis of inflammatory bowel disease colon mucosa demonstrates lack of major differences between Crohn's disease and ulcerative colitis

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5847456

Association of inflammatory bowel disease with familial Mediterranean fever in Turkish children.

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5847456

IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5847456

Recent trends in the prevalence of Crohn's disease and ulcerative colitis in a commercially insured US population.

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5847456

Association of the MEFV gene variations with inflammatory bowel disease in Turkey

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5847456

Activation of the pyrin inflammasome by intracellular Burkholderia cenocepacia

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5847456

Cytosolic flagellin receptor NLRC4 protects mice against mucosal and systemic challenges

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5847456

GENT: gene expression database of normal and tumor tissues

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5847456

NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5847456

A functional role for Nlrp6 in intestinal inflammation and tumorigenesis

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5847456

Inflammation-induced tumorigenesis in the colon is regulated by caspase-1 and NLRC4.

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5847456

IL-18 production downstream of the Nlrp3 inflammasome confers protection against colorectal tumor formation

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5847456

MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5847456

The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5847456

Immunity, Inflammation, and Cancer

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5847456

The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5847456

MEFV gene mutations and its impact on the clinical course in ulcerative colitis patients

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5847456

Intestinal mucosal barrier function in health and disease

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5847456

Genetic variation in the familial Mediterranean fever gene (MEFV) and risk for Crohn's disease and ulcerative colitis

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5847456

Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5847456

Crypt stem cells as the cells-of-origin of intestinal cancer

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5847456

Targeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis.

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5847456

Reducing small intestinal permeability attenuates colitis in the IL10 gene-deficient mouse

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5847456

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5847456

Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology.

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5847456

Increased frequency of mutations in the gene responsible for familial Mediterranean fever (MEFV) in a cohort of patients with ulcerative colitis: evidence for a potential disease-modifying effect?

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5847456

Predominant T helper type 2-inflammatory responses promote murine colon cancers

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5847456

Abdominal and digestive system associations of familial Mediterranean fever

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5847456

A novel inflammation‐related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5847456

The immunological and genetic basis of inflammatory bowel disease

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5847456

Targeted disruption of pyrin, the FMF protein, causes heightened sensitivity to endotoxin and a defect in macrophage apoptosis

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5847456

Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-gamma and TNF-alpha production

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5847456

Dextran sulfate sodium (DSS) colitis in rats: clinical, structural, and ultrastructural aspects

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5847456

IL-18 (IFN-gamma-inducing factor) regulates early cytokine production in, and promotes resolution of, bacterial infection in mice

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5847456

Unifying hypothesis for inflammatory bowel disease and associated colon cancer: sticking the pieces together with sugar

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5847456

Glycoprotein composition of colonic mucosa. Specific alterations in ulcerative colitis

29 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5847456

Ancient Missense Mutations in a New Member of the RoRet Gene Family Are Likely to Cause Familial Mediterranean Fever

29 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29203393

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Inflammatory bowel disease in non-Ashkenazi Jews with familial Mediterranean fever

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29203393

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The prevalence and geographic distribution of Crohn's disease and ulcerative colitis in the United States

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29203393

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1053/J.GASTRO.2017.11.276

1 reference

14 January 2018

PMC publication ID

5847456

0 references

1 reference

14 January 2018