(Q47414200)

15 January 2018

title

Calcimimetic and calcilytic therapies for inherited disorders of the calcium-sensing receptor signalling pathway. (English)

1 reference

15 January 2018

author

Fadil M. Hannan

series ordinal

1

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15 January 2018

Rajesh Thakker

series ordinal

3

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15 January 2018

Mie K Olesen

object named as

Mie K Olesen

series ordinal

2

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language of work or name

English

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publication date

11 November 2017

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15 January 2018

British Journal of Pharmacology

published in

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15 January 2018

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: G protein-coupled receptors

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Allosteric Modulation of the Calcium-sensing Receptor Rectifies Signaling Abnormalities Associated with G-protein α-11 Mutations Causing Hypercalcemic and Hypocalcemic Disorders

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Mutant Mice With Calcium-Sensing Receptor Activation Have Hyperglycemia That Is Rectified by Calcilytic Therapy

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Effect of Etelcalcetide vs Cinacalcet on Serum Parathyroid Hormone in Patients Receiving Hemodialysis With Secondary Hyperparathyroidism: A Randomized Clinical Trial.

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Positive and negative allosteric modulators promote biased signaling at the calcium-sensing receptor.

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Calcilytic Ameliorates Abnormalities of Mutant Calcium-Sensing Receptor (CaSR) Knock-In Mice Mimicking Autosomal Dominant Hypocalcemia (ADH).

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Cinacalcet monotherapy in neonatal severe hyperparathyroidism: a case study and review.

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Cinacalcet Rectifies Hypercalcemia in a Patient With Familial Hypocalciuric Hypercalcemia Type 2 (FHH2) Caused by a Germline Loss-of-Function Gα11 Mutation.

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Gα11 mutation in mice causes hypocalcemia rectifiable by calcilytic therapy.

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Antagonizing the parathyroid calcium receptor stimulates parathyroid hormone secretion and bone formation in osteopenic rats

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Activation of the extracellular calcium-sensing receptor initiates insulin secretion from human islets of Langerhans: involvement of protein kinases

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A phase 2, randomized, placebo-controlled, dose-ranging study of the calcium-sensing receptor antagonist MK-5442 in the treatment of postmenopausal women with osteoporosis

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Disorders of the calcium-sensing receptor and partner proteins: insights into the molecular basis of calcium homeostasis

21 January 2018

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Adaptor protein-2 sigma subunit mutations causing familial hypocalciuric hypercalcaemia type 3 (FHH3) demonstrate genotype-phenotype correlations, codon bias and dominant-negative effects

21 January 2018

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Identification of 70 calcium-sensing receptor mutations in hyper- and hypo-calcaemic patients: evidence for clustering of extracellular domain mutations at calcium-binding sites.

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The Calcilytic Agent NPS 2143 Rectifies Hypocalcemia in a Mouse Model With an Activating Calcium-Sensing Receptor (CaSR) Mutation: Relevance to Autosomal Dominant Hypocalcemia Type 1 (ADH1).

21 January 2018

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Activating calcium-sensing receptor mutation in the mouse is associated with cataracts and ectopic calcification

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Amino alcohol- (NPS-2143) and quinazolinone-derived calcilytics (ATF936 and AXT914) differentially mitigate excessive signalling of calcium-sensing receptor mutants causing Bartter syndrome Type 5 and autosomal dominant hypocalcemia

21 January 2018

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Effect of the calcimimetic R-568 [3-(2-chlorophenyl)-N-((1R)-1-(3-methoxyphenyl)ethyl)-1-propanamine] on correcting inactivating mutations in the human calcium-sensing receptor

21 January 2018

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Characterization of highly efficacious allosteric agonists of the human calcium-sensing receptor

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Homology modeling of the transmembrane domain of the human calcium sensing receptor and localization of an allosteric binding site

21 January 2018

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Calcimimetic compound upregulates decreased calcium-sensing receptor expression level in parathyroid glands of rats with chronic renal insufficiency.

21 January 2018

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Calcimimetic and calcilytic drugs: just for parathyroid cells?

21 January 2018

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Calcimimetic and Calcilytic Drugs: Feats, Flops, and Futures

21 January 2018

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Pharmacodynamics of the Type II Calcimimetic Compound Cinacalcet HCl

21 January 2018

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Calcimimetics with potent and selective activity on the parathyroid calcium receptor

21 January 2018

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Mutations affecting G-protein subunit α11 in hypercalcemia and hypocalcemia

21 January 2018

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Mutations in AP2S1 cause familial hypocalciuric hypercalcemia type 3.

21 January 2018

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Positive and negative allosteric modulators of the Ca2+-sensing receptor interact within overlapping but not identical binding sites in the transmembrane domain

21 January 2018

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Clinical and biochemical outcomes of cinacalcet treatment of familial hypocalciuric hypercalcemia: a case series

21 January 2018

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Neonatal hyperparathyroidism with a heterozygous calcium-sensing receptor (CASR) R185Q mutation: clinical benefit from cinacalcet

21 January 2018

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Knockin mouse with mutant Gα11 mimics human inherited hypocalcemia and is rescued by pharmacologic inhibitors

21 January 2018

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Novel inactivating mutations of the calcium-sensing receptor: the calcimimetic NPS R-568 improves signal transduction of mutant receptors

21 January 2018

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Utility of Cinacalcet in Familial Hypocalciuric Hypercalcemia

21 January 2018

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The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands

21 January 2018

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Cinacalcet upregulates calcium-sensing receptors of parathyroid glands in hemodialysis patients.

21 January 2018

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PTH(1-34) replacement therapy in a child with hypoparathyroidism caused by a sporadic calcium receptor mutation

21 January 2018

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Normalization of serum calcium by cinacalcet in a patient with hypercalcaemia due to a de novo inactivating mutation of the calcium-sensing receptor.

21 January 2018

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Neonatal severe hyperparathyroidism: genotype/phenotype correlation and the use of pamidronate as rescue therapy

21 January 2018

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Association between activating mutations of calcium-sensing receptor and Bartter's syndrome

21 January 2018

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Pharmacochaperone-mediated rescue of calcium-sensing receptor loss-of-function mutants

21 January 2018

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Successful treatment of neonatal severe hyperparathyroidism with cinacalcet in two patients.

21 January 2018

1 reference

PubMed Central

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6177618

Recurrent pancreatitis in a patient with familial hypocalciuric hypercalcaemia treated successfully with cinacalcet

2 November 2018

1 reference

PubMed Central

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6177618

Calcilytic compounds: potent and selective Ca2+ receptor antagonists that stimulate secretion of parathyroid hormone.

2 November 2018

1 reference

PubMed Central

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6177618

The effects of ronacaleret, a calcium-sensing receptor antagonist, on bone mineral density and biochemical markers of bone turnover in postmenopausal women with low bone mineral density

2 November 2018

1 reference

12 December 2020

Short-term inhibition of parathyroid hormone secretion by a calcium-receptor agonist in patients with primary hyperparathyroidism

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12 December 2020

Agonist-driven maturation and plasma membrane insertion of calcium-sensing receptors dynamically control signal amplitude

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12 December 2020

Novel activating mutations of the calcium-sensing receptor: the calcilytic NPS-2143 mitigates excessive signal transduction of mutant receptors

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12 December 2020

An orally active calcium-sensing receptor antagonist that transiently increases plasma concentrations of PTH and stimulates bone formation

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12 December 2020

Correction of hypercalcaemia by cinacalcet in familial hypocalciuric hypercalcaemia

1 reference

12 December 2020

Cinacalcet Treatment in an Adolescent With Concurrent 22q11.2 Deletion Syndrome and Familial Hypocalciuric Hypercalcemia Type 3 Caused by AP2S1 Mutation

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12 December 2020

A calcimimetic agent acutely suppresses parathyroid hormone levels in patients with chronic renal failure. Rapid communication

1 reference

12 December 2020

Identifiers

DOI

10.1111/BPH.14086

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15 January 2018

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1 reference

15 January 2018