(Q47722821)

4 July 2018

title

Development of an airway mucus defect in the cystic fibrosis rat. (English)

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4 July 2018

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Steven M Rowe

10

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Eric Sorscher

9

object named as

Eric J Sorscher

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4 July 2018

Ashley M Oden

5

object named as

Ashley M Oden

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4 July 2018

6

Kengyeh K Chu

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4 July 2018

4

Katherine L Tuggle

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4 July 2018

Susan E Birket

1

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4 July 2018

Joy M Davis

2

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4 July 2018

Courtney M Fernandez

3

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4 July 2018

Guillermo J Tearney

7

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4 July 2018

Michelle V Fanucchi

8

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4 July 2018

publication date

11 January 2018

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4 July 2018

published in

JCI insight

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4 July 2018

volume

3

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4 July 2018

issue

1

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4 July 2018

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5821204/fullTextXML

inferred from PubMed Central ID database lookup

cites work

The normal trachea is cleaned by MUC5B mucin bundles from the submucosal glands coated with the MUC5AC mucin

1 reference

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Gel-forming mucins form distinct morphologic structures in airways

10 July 2018

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High-resolution mucociliary transport measurement in live excised large animal trachea using synchrotron X-ray imaging.

10 July 2018

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Defective postsecretory maturation of MUC5B mucin in cystic fibrosis airways

10 July 2018

1 reference

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Particle-Tracking Microrheology Using Micro-Optical Coherence Tomography

10 July 2018

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A systematic review of studies examining the rate of lung function decline in patients with cystic fibrosis

10 July 2018

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Combination therapy with cystic fibrosis transmembrane conductance regulator modulators augment the airway functional microanatomy

10 July 2018

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Acidic pH increases airway surface liquid viscosity in cystic fibrosis

10 July 2018

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Cystic fibrosis in young children: A review of disease manifestation, progression, and response to early treatment

10 July 2018

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Hyper-osmolarity and calcium chelation: Effects on cystic fibrosis mucus.

10 July 2018

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Oxidation increases mucin polymer cross-links to stiffen airway mucus gels

10 July 2018

1 reference

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Origins of cystic fibrosis lung disease

10 July 2018

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Defective innate immunity and hyperinflammation in newborn cystic fibrosis transmembrane conductance regulator-knockout ferret lungs

10 July 2018

1 reference

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Impaired mucus detachment disrupts mucociliary transport in a piglet model of cystic fibrosis.

10 July 2018

1 reference

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A functional anatomic defect of the cystic fibrosis airway

10 July 2018

1 reference

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Cystic fibrosis airway secretions exhibit mucin hyperconcentration and increased osmotic pressure

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821204

Characterization of defects in ion transport and tissue development in cystic fibrosis transmembrane conductance regulator (CFTR)-knockout rats

10 July 2018

1 reference

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A biophysical basis for mucus solids concentration as a candidate biomarker for airways disease

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821204

Assessing mucociliary transport of single particles in vivo shows variable speed and preference for the ventral trachea in newborn pigs

10 July 2018

1 reference

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Lung clearance index as an outcome measure for clinical trials in young children with cystic fibrosis. A pilot study using inhaled hypertonic saline

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821204

Method for quantitative study of airway functional microanatomy using micro-optical coherence tomography

10 July 2018

1 reference

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Mucociliary transport in porcine trachea: differential effects of inhibiting chloride and bicarbonate secretion

10 July 2018

1 reference

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A periciliary brush promotes the lung health by separating the mucus layer from airway epithelia

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821204

Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821204

The challenges and promises of new therapies for cystic fibrosis

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821204

Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype.

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821204

Inhaled hypertonic saline in infants and children younger than 6 years with cystic fibrosis: the ISIS randomized controlled trial

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821204

Pulmonary exacerbations in cystic fibrosis

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821204

New animal models of cystic fibrosis: what are they teaching us?

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821204

Mouse models of cystic fibrosis: phenotypic analysis and research applications

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821204

Mucous solids and liquid secretion by airways: studies with normal pig, cystic fibrosis human, and non-cystic fibrosis human bronchi

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821204

Disease phenotype of a ferret CFTR-knockout model of cystic fibrosis.

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821204

A new role for bicarbonate in mucus formation

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821204

Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821204

Normal mouse intestinal mucus release requires cystic fibrosis transmembrane regulator-dependent bicarbonate secretion

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821204

Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821204

Cystic fibrosis: impaired bicarbonate secretion and mucoviscidosis

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821204

Fluid secretion by submucosal glands of the tracheobronchial airways

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821204

A physical linkage between cystic fibrosis airway surface dehydration and Pseudomonas aeruginosa biofilms.

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821204

A morphometric study of mucins and small airway plugging in cystic fibrosis.

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821204

Cystic fibrosis mouse models

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821204

Regulation of airway surface liquid volume and mucus transport by active ion transport

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821204

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821204

Cystic fibrosis lung disease: genetic influences, microbial interactions, and radiological assessment

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821204

Role of airway surface liquid and submucosal glands in cystic fibrosis lung disease

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821204

Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821204

Bicarbonate conductance and pH regulatory capability of cystic fibrosis transmembrane conductance regulator

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821204

Quantitative evaluation of the development of tracheal submucosal glands in infants with cystic fibrosis and control infants

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821204

Missing Cl conductance in cystic fibrosis

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821204

An apical-membrane chloride channel in human tracheal epithelium

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821204

Normal mucus formation requires cAMP-dependent HCO3- secretion and Ca2+-mediated mucin exocytosis

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821204

Hyperacidity of secreted fluid from submucosal glands in early cystic fibrosis

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821204

Ionic mechanism of forskolin-induced liquid secretion by porcine bronchi

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821204

Submucosal gland dysfunction as a primary defect in cystic fibrosis

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821204

Immunohistochemical demonstration of carbonic anhydrase isoenzyme VI (CA VI) expression in rat lower airways and lung

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821204

Effect of ambient air pollution on pulmonary exacerbations and lung function in cystic fibrosis

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821204

Enhanced viscoelasticity of human cystic fibrotic sputum correlates with increasing microheterogeneity in particle transport.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821204

Distribution of tracheal and laryngeal mucous glands in some rodents and the rabbit

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821204

OligoG CF-5/20 normalizes cystic fibrosis mucus by chelating calcium

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821204

Hypertonic saline in treatment of pulmonary disease in cystic fibrosis

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821204

Submucosal glands are the predominant site of CFTR expression in the human bronchus

1 December 2018

1 reference

12 December 2020

Effect of anion transport inhibition on mucus secretion by airway submucosal glands

1 reference

12 December 2020

Inhibition of airway liquid secretion and its effect on the physical properties of airway mucus

1 reference

12 December 2020

The pathogenesis of fibrocystic disease of the pancreas; a study of 36 cases with special reference to the pulmonary lesions

1 reference

12 December 2020

Airway epithelial cells: 'Bicarbonate in' ≠ 'Bicarbonate out'

1 reference

12 December 2020

The diagnosis of cystic fibrosis

1 reference

12 December 2020

10.1172/JCI.INSIGHT.97199

Identifiers

DOI

1 reference

4 July 2018

PMC publication ID

5821204

1 reference

4 July 2018

PubMed publication ID

29321377

1 reference

4 July 2018