(Q47738084)

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The dual orexin receptor antagonist, DORA-22, lowers histamine levels in the lateral hypothalamus and prefrontal cortex without lowering hippocampal acetylcholine.

scientific article published on 26 April 2017

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18 March 2020

The dual orexin receptor antagonist, DORA-22, lowers histamine levels in the lateral hypothalamus and prefrontal cortex without lowering hippocampal acetylcholine (English)

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18 March 2020

Christopher Winrow

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18 March 2020

Anthony L Gotter

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18 March 2020

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Lihang Yao

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18 March 2020

Andres D Ramirez

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18 March 2020

Anthony J Roecker

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18 March 2020

Steven V Fox

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18 March 2020

Jason M Uslaner

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18 March 2020

Sean M Smith

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18 March 2020

Robert Hodgson

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Paul J Coleman

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John J Renger

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1 June 2017

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18 March 2020

Journal of Neurochemistry

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18 March 2020

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18 March 2020

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18 March 2020

Neural substrates of awakening probed with optogenetic control of hypocretin neurons

1 reference

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Association between A2a receptor gene polymorphisms and caffeine-induced anxiety

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Acetylcholine, histamine, and cognition: two sides of the same coin.

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A selective orexin-1 receptor antagonist attenuates stress-induced hyperarousal without hypnotic effects

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Promotion of sleep by targeting the orexin system in rats, dogs and humans

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Sleep homeostasis modulates hypocretin-mediated sleep-to-wake transitions

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Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation

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A comparison of the residual effects of zaleplon and zolpidem following administration 5 to 2 h before awakening

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Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems

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Blockade of orexin-1 receptors attenuates orexin-2 receptor antagonism-induced sleep promotion in the rat.

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Orexin (hypocretin)/dynorphin neurons control GABAergic inputs to tuberomammillary neurons

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Memory retrieval of inhibitory avoidance requires histamine H1 receptor activation in the hippocampus

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21 January 2018

Quantitative electroencephalography within sleep/wake states differentiates GABAA modulators eszopiclone and zolpidem from dual orexin receptor antagonists in rats

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21 January 2018

Orexin receptors as therapeutic drug targets

1 reference

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21 January 2018

Orexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to Man.

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21 January 2018

Diurnal variation in CSF orexin-A in healthy male subjects.

1 reference

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21 January 2018

In the Zzz zone: the effects of Z-drugs on human performance and driving

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21 January 2018

Suvorexant in Patients With Insomnia: Results From Two 3-Month Randomized Controlled Clinical Trials.

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21 January 2018

Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine

1 reference

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21 January 2018

Caffeine promotes glutamate and histamine release in the posterior hypothalamus

1 reference

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21 January 2018

Evidence for histaminergic arousal mechanisms in the hypothalamus of cat.

1 reference

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21 January 2018

The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene

1 reference

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21 January 2018

The dual orexin receptor antagonist almorexant induces sleep and decreases orexin-induced locomotion by blocking orexin 2 receptors

1 reference

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21 January 2018

Differential expression of orexin receptors 1 and 2 in the rat brain.

1 reference

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21 January 2018

Safety and efficacy of suvorexant during 1-year treatment of insomnia with subsequent abrupt treatment discontinuation: a phase 3 randomised, double-blind, placebo-controlled trial

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21 January 2018

A new benzodiazepine pharmacology.

1 reference

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21 January 2018

Dual hypocretin receptor antagonism is more effective for sleep promotion than antagonism of either receptor alone

1 reference

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21 January 2018

Anandamide enhances extracellular levels of adenosine and induces sleep: an in vivo microdialysis study.

1 reference

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21 January 2018

Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists.

1 reference

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21 January 2018

Histamine-containing neurons in the rat hypothalamus

1 reference

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21 January 2018

Characterisation of the effects of caffeine on sleep in the rat: a potential model of sleep disruption.

1 reference

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21 January 2018

The H1- and H2-histamine blockers chlorpheniramine and ranitidine applied to the nucleus basalis magnocellularis region modulate anxiety and reinforcement related processes.

1 reference

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21 January 2018

Dual orexin receptor antagonists show distinct effects on locomotor performance, ethanol interaction and sleep architecture relative to gamma-aminobutyric acid-A receptor modulators.

1 reference

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21 January 2018

Insomnia pharmacotherapy

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Sedative, memory, and performance effects of hypnotics.

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The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness

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Hypothalamic regulation of sleep and circadian rhythms

1 reference

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21 January 2018

Orexins/hypocretins cause sharp wave- and theta-related synaptic plasticity in the hippocampus via glutamatergic, gabaergic, noradrenergic, and cholinergic signaling.

1 reference

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21 January 2018

Orexins/hypocretins control bistability of hippocampal long-term synaptic plasticity through co-activation of multiple kinases.

1 reference

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Acetylcholine and the regulation of REM sleep: basic mechanisms and clinical implications for affective illness and narcolepsy

1 reference

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21 January 2018

Diurnal variation in orexin A immunoreactivity and prepro-orexin mRNA in the rat central nervous system.

1 reference

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21 January 2018

Orexin receptor antagonists differ from standard sleep drugs by promoting sleep at doses that do not disrupt cognition.

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Measuring dopaminergic function in the 6-OHDA-lesioned rat: a comparison of PET and microdialysis

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21 January 2018

Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes

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21 January 2018

Discovery and development of orexin receptor antagonists as therapeutics for insomnia

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1 reference

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21 January 2018

Wakefulness Is Governed by GABA and Histamine Cotransmission

1 reference

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Histamine release in the basal forebrain mediates cortical activation through cholinergic neurons.

1 reference

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10.1111/JNC.14055

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Europe PubMed Central

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18 March 2020

1 reference

Europe PubMed Central

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18 March 2020

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