(Q47745453)

5 February 2018

title

Sirt1's complex roles in neuroprotection (English)

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5 February 2018

author name string

Bor Luen Tang

series ordinal

1

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5 February 2018

publication date

1 December 2009

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5 February 2018

Cellular and Molecular Neurobiology

published in

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5 February 2018

volume

29

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5 February 2018

issue

8

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5 February 2018

page(s)

1093-1103

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5 February 2018

https://scigraph.springernature.com/pub.10.1007/s10571-009-9414-2

exact match

0 references

cites work

SIRT1: linking adaptive cellular responses to aging-associated changes in organismal physiology

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Resveratrol protects ROS-induced cell death by activating AMPK in H9c2 cardiac muscle cells

21 January 2018

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12 December 2020

Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice

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12 December 2020

Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1

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12 December 2020

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

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12 December 2020

Dietary oxyresveratrol prevents parkinsonian mimetic 6-hydroxydopamine neurotoxicity

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12 December 2020

Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington's disease.

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12 December 2020

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

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12 December 2020

Caloric restriction attenuates Abeta-deposition in Alzheimer transgenic models

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12 December 2020

Resveratrol in prevention and treatment of common clinical conditions of aging

1 reference

12 December 2020

The Sir2 family of protein deacetylases

1 reference

12 December 2020

Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1

1 reference

12 December 2020

Resveratrol, a red wine polyphenol, protects spinal cord from ischemia-reperfusion injury

1 reference

12 December 2020

Alzheimer's disease: channeling APP to non-amyloidogenic processing

1 reference

12 December 2020

Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity

1 reference

12 December 2020

SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction

1 reference

12 December 2020

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

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12 December 2020

Sirtuin activators mimic caloric restriction and delay ageing in metazoans

1 reference

12 December 2020

Sirtuins: critical regulators at the crossroads between cancer and aging

1 reference

12 December 2020

FOXO transcription factors: key regulators of cell fate

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12 December 2020

SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons

1 reference

12 December 2020

Sirtuins in aging and age-related disease.

1 reference

12 December 2020

Resveratrol--a boon for treating Alzheimer's disease?

1 reference

12 December 2020

Increased life span due to calorie restriction in respiratory-deficient yeast

1 reference

12 December 2020

Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae

1 reference

12 December 2020

trans-Resveratrol induces apoptosis in human breast cancer cells MCF-7 by the activation of MAP kinases pathways

1 reference

12 December 2020

Increase in activity during calorie restriction requires Sirt1

1 reference

12 December 2020

Huntington's disease: from huntingtin function and dysfunction to therapeutic strategies.

1 reference

12 December 2020

SIRT1 is significantly elevated in mouse and human prostate cancer.

1 reference

12 December 2020

Mammalian SIRT1 represses forkhead transcription factors

1 reference

12 December 2020

Necdin regulates p53 acetylation via Sirtuin1 to modulate DNA damage response in cortical neurons

1 reference

12 December 2020

SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization

1 reference

12 December 2020

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

1 reference

12 December 2020

Tracking in the Wlds--the hunting of the SIRT and the luring of the Draper

1 reference

12 December 2020

Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients

1 reference

12 December 2020

Calorie restriction attenuates Alzheimer's disease type brain amyloidosis in Squirrel monkeys (Saimiri sciureus).

1 reference

12 December 2020

C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging

1 reference

12 December 2020

Sir2 mediates apoptosis through JNK-dependent pathways in Drosophila

1 reference

12 December 2020

Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction

1 reference

12 December 2020

Evidence that the Rate of Wallerian Degeneration is Controlled by a Single Autosomal Dominant Gene

1 reference

12 December 2020

Negative control of p53 by Sir2alpha promotes cell survival under stress

1 reference

12 December 2020

Linking sirtuins, IGF-I signaling, and starvation

1 reference

12 December 2020

A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span

1 reference

12 December 2020

Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses

1 reference

12 December 2020

The sirtuin inhibitor nicotinamide enhances neuronal cell survival during acute anoxic injury through AKT, BAD, PARP, and mitochondrial associated "anti-apoptotic" pathways

1 reference

12 December 2020

Sirtuin 2, a mammalian homolog of yeast silent information regulator-2 longevity regulator, is an oligodendroglial protein that decelerates cell differentiation through deacetylating alpha-tubulin

1 reference

12 December 2020

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

1 reference

12 December 2020

Comparative analysis of the effects of resveratrol in two apoptotic models: inhibition of complex I and potassium deprivation in cerebellar neurons.

1 reference

12 December 2020

Wld S requires Nmnat1 enzymatic activity and N16-VCP interactions to suppress Wallerian degeneration

1 reference

12 December 2020

Nonsteroidal Anti-Inflammatory Drugs Can Lower Amyloidogenic Aß 42 by Inhibiting Rho

1 reference

12 December 2020

HST2 mediates SIR2-independent life-span extension by calorie restriction

1 reference

12 December 2020

Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice

1 reference

12 December 2020

SIRT1 transgenic mice show phenotypes resembling calorie restriction

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12 December 2020

daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans

1 reference

12 December 2020

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

1 reference

12 December 2020

Ku70 suppresses the apoptotic translocation of Bax to mitochondria.

1 reference

12 December 2020

Mammalian Sir2-related protein (SIRT) 2-mediated modulation of resistance to axonal degeneration in slow Wallerian degeneration mice: a crucial role of tubulin deacetylation

1 reference

12 December 2020

Molecular mechanism of apoptosis induction by resveratrol, a natural cancer chemopreventive agent

1 reference

12 December 2020

Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase

1 reference

12 December 2020

Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice

1 reference

12 December 2020

Sirtuins as potential targets for metabolic syndrome

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12 December 2020

Stimulation of nicotinamide adenine dinucleotide biosynthetic pathways delays axonal degeneration after axotomy

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12 December 2020

Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins

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12 December 2020

The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility

1 reference

12 December 2020

Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation.

1 reference

12 December 2020

Regulation of forkhead transcription factor FoxO3a contributes to calorie restriction-induced prevention of Alzheimer's disease-type amyloid neuropathology and spatial memory deterioration

1 reference

12 December 2020

The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis

1 reference

12 December 2020

Resveratrol protects dopaminergic neurons in midbrain slice culture from multiple insults.

1 reference

12 December 2020

Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease

1 reference

12 December 2020

A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function

1 reference

12 December 2020

SIRT1, neuronal cell survival and the insulin/IGF-1 aging paradox

1 reference

12 December 2020

Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans.

1 reference

12 December 2020

Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration

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12 December 2020

Tissue-specific regulation of SIRT1 by calorie restriction

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12 December 2020

Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage

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12 December 2020

Calorie restriction, SIRT1 and metabolism: understanding longevity

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12 December 2020

Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae

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12 December 2020

NAD(+) and axon degeneration revisited: Nmnat1 cannot substitute for Wld(S) to delay Wallerian degeneration

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12 December 2020

Sirt1 contributes critically to the redox-dependent fate of neural progenitors.

1 reference

12 December 2020

SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}

1 reference

12 December 2020

Involvement of the ubiquitin-proteasome system in the early stages of wallerian degeneration

1 reference

12 December 2020

SirT1 gain of function increases energy efficiency and prevents diabetes in mice

1 reference

12 December 2020

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

1 reference

12 December 2020

The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase

1 reference

12 December 2020

Caloric restriction attenuates beta-amyloid neuropathology in a mouse model of Alzheimer's disease

1 reference

12 December 2020

Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells

1 reference

12 December 2020

Wld S protein requires Nmnat activity and a short N-terminal sequence to protect axons in mice

1 reference

12 December 2020

Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction

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12 December 2020

Paths of convergence: sirtuins in aging and neurodegeneration

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12 December 2020

SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis

1 reference

12 December 2020

Resveratrol abolishes resistance to axonal degeneration in slow Wallerian degeneration (WldS) mice: activation of SIRT2, an NAD-dependent tubulin deacetylase.

1 reference

12 December 2020

Life-span extension in yeast.

1 reference

12 December 2020

Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma

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12 December 2020

Predominant expression of Sir2alpha, an NAD-dependent histone deacetylase, in the embryonic mouse heart and brain.

1 reference

12 December 2020

SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging

1 reference

12 December 2020

Resveratrol, a natural red wine polyphenol, reduces ischemia-reperfusion-induced spinal cord injury

1 reference

12 December 2020

The Sir 2 family of protein deacetylases

1 reference

12 December 2020

Resveratrol mimics ischemic preconditioning in the brain

1 reference

12 December 2020

Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha

1 reference

12 December 2020

Axon pathology in neurological disease: a neglected therapeutic target

1 reference

12 December 2020

Overview of caloric restriction and ageing

1 reference

12 December 2020

Sir2 mediates longevity in the fly through a pathway related to calorie restriction

1 reference

12 December 2020

Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans

1 reference

12 December 2020

Modulation of statin-activated shedding of Alzheimer APP ectodomain by ROCK

1 reference

12 December 2020

Resveratrol improves health and survival of mice on a high-calorie diet

1 reference

12 December 2020

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

1 reference

12 December 2020

Opposing effects of sirtuins on neuronal survival: SIRT1-mediated neuroprotection is independent of its deacetylase activity

1 reference

12 December 2020

SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling

1 reference

12 December 2020

Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis

1 reference

12 December 2020

Sir2-independent life span extension by calorie restriction in yeast

1 reference

12 December 2020

Extrachromosomal rDNA circles--a cause of aging in yeast

1 reference

12 December 2020

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

1 reference

12 December 2020

Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress

1 reference

12 December 2020

Role of sirtuin histone deacetylase SIRT1 in prostate cancer. A target for prostate cancer management via its inhibition?

1 reference

12 December 2020

The interaction between FOXO and SIRT1: tipping the balance towards survival

1 reference

12 December 2020

Brain SIRT1: anatomical distribution and regulation by energy availability

1 reference

12 December 2020

Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis

1 reference

12 December 2020

Neuronal protection by sirtuins in Alzheimer's disease

1 reference

12 December 2020

A local mechanism mediates NAD-dependent protection of axon degeneration

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12 December 2020

SIRT1 activation confers neuroprotection in experimental optic neuritis

1 reference

12 December 2020

The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth

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12 December 2020

Sir2 blocks extreme life-span extension.

1 reference

12 December 2020

Regulation of C. elegans life-span by insulinlike signaling in the nervous system

1 reference

12 December 2020

10.1007/S10571-009-9414-2

Identifiers

DOI

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5 February 2018

PubMed ID

19462229

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5 February 2018