(Q47853126)

http://europepmc.org/abstract/PMC/5773483

6 February 2018

title

Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures (English)

1 reference

http://europepmc.org/abstract/PMC/5773483

6 February 2018

author

Tiago Gil Oliveira

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29348617%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

author name string

André M Miranda

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29348617%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Zofia M Lasiecka

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29348617%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Yimeng Xu

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29348617%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Jessi Neufeld

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29348617%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Sanjid Shahriar

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29348617%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Sabrina Simoes

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29348617%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Robin B Chan

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29348617%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Scott A Small

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29348617%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Gilbert Di Paolo

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29348617%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

language of work or name

English

0 references

publication date

18 January 2018

1 reference

http://europepmc.org/abstract/PMC/5773483

6 February 2018

published in

Nature Communications

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29348617%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

volume

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29348617%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29348617%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

page(s)

291

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29348617%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

5 June 2020

copyright license

start time

18 January 2018

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5773483/fullTextXML

inferred from PubMed Central ID database lookup

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5773483/fullTextXML

inferred from PubMed Central ID database lookup

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Neutral Sphingomyelinase-2 Deficiency Ameliorates Alzheimer's Disease Pathology and Improves Cognition in the 5XFAD Mouse

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22 May 2018

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APP overexpression in the absence of NPC1 exacerbates metabolism of amyloidogenic proteins of Alzheimer's disease

22 May 2018

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p62/SQSTM1 functions as a signaling hub and an autophagy adaptor

22 May 2018

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LAPTM4B facilitates late endosomal ceramide export to control cell death pathways.

22 May 2018

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Evidence that the rab5 effector APPL1 mediates APP-βCTF-induced dysfunction of endosomes in Down syndrome and Alzheimer's disease

22 May 2018

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ESCRTs regulate amyloid precursor protein sorting in multivesicular bodies and intracellular amyloid-β accumulation

22 May 2018

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22 May 2018

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22 May 2018

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Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

22 May 2018

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A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy

22 May 2018

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Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

22 May 2018

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22 May 2018

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22 May 2018

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High sphingomyelin levels induce lysosomal damage and autophagy dysfunction in Niemann Pick disease type A.

22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury

22 May 2018

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Phosphatidylinositol-3-phosphate regulates sorting and processing of amyloid precursor protein through the endosomal system

22 May 2018

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Alpha-synuclein induces lysosomal rupture and cathepsin dependent reactive oxygen species following endocytosis

22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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22 May 2018

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The exosome secretory pathway transports amyloid precursor protein carboxyl-terminal fragments from the cell into the brain extracellular space

22 May 2018

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22 May 2018

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Functional aspects of membrane association of reggie/flotillin proteins

22 May 2018

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22 May 2018

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Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission.

22 May 2018

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Pik3c3 deletion in pyramidal neurons results in loss of synapses, extensive gliosis and progressive neurodegeneration

22 May 2018

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Macroautophagy is not directly involved in the metabolism of amyloid precursor protein

22 May 2018

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Exosome secretion ameliorates lysosomal storage of cholesterol in Niemann-Pick type C disease

22 May 2018

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Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations

22 May 2018

1 reference

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Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway

22 May 2018

1 reference

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22 May 2018

1 reference

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A phosphoinositide switch controls the maturation and signaling properties of APPL endosomes

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5773483

Sorting of lysosomal proteins

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5773483

Ceramide triggers budding of exosome vesicles into multivesicular endosomes

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5773483

Inhibition of gamma-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5773483

Alkalizing drugs induce accumulation of amyloid precursor protein by-products in luminal vesicles of multivesicular bodies

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5773483

Mast cell- and dendritic cell-derived exosomes display a specific lipid composition and an unusual membrane organization.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5773483

Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5773483

Late endosomal membranes rich in lysobisphosphatidic acid regulate cholesterol transport

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5773483

Disruption of amyloid precursor protein ubiquitination selectively increases amyloid β (Aβ) 40 levels via presenilin 2-mediated cleavage

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5773483

Endosomal Traffic Jams Represent a Pathogenic Hub and Therapeutic Target in Alzheimer's Disease

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5773483

A Clinical and Molecular Genetic Study of 50 Families with Autosomal Recessive Parkinsonism Revealed Known and Novel Gene Mutations.

14 August 2018

1 reference

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Loss of Bin1 Promotes the Propagation of Tau Pathology

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5773483

Ultrastructural analysis of autophagosome organization using mammalian autophagy-deficient cells.

14 August 2018

1 reference

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Effect of lysosomal storage on bis(monoacylglycero)phosphate.

14 August 2018

1 reference

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The phosphatidylinositol 3-kinase inhibitor wortmannin alters the metabolism of the Alzheimer's amyloid precursor protein.

14 August 2018

1 reference

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Isolation and characterization of exosomes from cell culture supernatants and biological fluids

14 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FS41467-017-02533-W

7 January 2021

inferred from DOI database lookup

Subcellular fractionation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29348617

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/S41467-017-02533-W

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29348617%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29348617%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

PubMed publication ID

29348617

1 reference