(Q47870743)

6 February 2018

title

Effects of metformin on colorectal cancer stem cells depend on alterations in glutamine metabolism (English)

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6 February 2018

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neoplastic stem cells

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Jae Hee Cheon

10

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9

Sung Pil Hong

1 reference

6 February 2018

author name string

Jae Hyun Kim

1

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6 February 2018

Kyoung Jin Lee

2

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6 February 2018

Yoojeong Seo

3

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6 February 2018

Ji-Hee Kwon

4

1 reference

6 February 2018

Jae Pil Yoon

5

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6 February 2018

Jo Yeon Kang

6

1 reference

6 February 2018

Hyun Jung Lee

7

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6 February 2018

Soo Jung Park

8

1 reference

6 February 2018

Won Ho Kim

11

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6 February 2018

Tae Ii Kim

12

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6 February 2018

language of work or name

English

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publication date

11 January 2018

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6 February 2018

published in

Scientific Reports

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6 February 2018

volume

8

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6 February 2018

issue

1

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6 February 2018

page(s)

409

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6 February 2018

Creative Commons Attribution 4.0 International

copyright license

start time

11 January 2018

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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exact match

https://scigraph.springernature.com/pub.10.1038/s41598-017-18762-4

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cites work

ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer.

1 reference

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Glutamine and alanyl-glutamine promote crypt expansion and mTOR signaling in murine enteroids

22 May 2018

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Lactate dehydrogenase 5: an old friend and a new hope in the war on cancer

22 May 2018

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Initial therapy with FOLFOXIRI and bevacizumab for metastatic colorectal cancer.

22 May 2018

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Upregulated SLC1A5 promotes cell growth and survival in colorectal cancer

22 May 2018

1 reference

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22 May 2018

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Discovery of selective inhibitors of Glutaminase-2, which inhibit mTORC1, activate autophagy and inhibit proliferation in cancer cells

22 May 2018

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CpG island methylator phenotype is associated with response to adjuvant irinotecan-based therapy for stage III colon cancer.

22 May 2018

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Chemopreventive drugs: mechanisms via inhibition of cancer stem cells in colorectal cancer

22 May 2018

1 reference

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Expression of glutaminase is upregulated in colorectal cancer and of clinical significance

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5765079

Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides.

22 May 2018

1 reference

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Inhibition of lactate dehydrogenase activity as an approach to cancer therapy

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5765079

Metformin: a potential therapeutic agent for recurrent colon cancer

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5765079

Tumour heterogeneity and cancer cell plasticity

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5765079

Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism.

22 May 2018

1 reference

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Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5765079

Metformin and cancer: from the old medicine cabinet to pharmacological pitfalls and prospects

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5765079

Energy metabolism of cancer: Glycolysis versus oxidative phosphorylation (Review).

22 May 2018

1 reference

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Knockdown of lactate dehydrogenase A suppresses tumor growth and metastasis of human hepatocellular carcinoma

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5765079

Addition of cetuximab to chemotherapy as first-line treatment for KRAS wild-type metastatic colorectal cancer: pooled analysis of the CRYSTAL and OPUS randomised clinical trials

22 May 2018

1 reference

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The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type.

22 May 2018

1 reference

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Glutamine fuels a vicious cycle of autophagy in the tumor stroma and oxidative mitochondrial metabolism in epithelial cancer cells: implications for preventing chemotherapy resistance

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5765079

Reduced risk of colorectal cancer with metformin therapy in patients with type 2 diabetes: a meta-analysis

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5765079

Metformin decreases the dose of chemotherapy for prolonging tumor remission in mouse xenografts involving multiple cancer cell types

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5765079

Empowering self-renewal and differentiation: the role of mitochondria in stem cells

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5765079

Annual report to the nation on the status of cancer, 1975-2006, featuring colorectal cancer trends and impact of interventions (risk factors, screening, and treatment) to reduce future rates

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5765079

Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5765079

Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5765079

Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5765079

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5765079

Systematic review of microsatellite instability and colorectal cancer prognosis

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5765079

Why do cancers have high aerobic glycolysis?

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5765079

FOXM1-Induced PRX3 Regulates Stemness and Survival of Colon Cancer Cells via Maintenance of Mitochondrial Function

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5765079

Metformin use is associated with a decreased incidence of colorectal adenomas in diabetic patients with previous colorectal cancer

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5765079

Metformin suppresses azoxymethane-induced colorectal aberrant crypt foci by activating AMP-activated protein kinase

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5765079

Metformin blocks the stimulative effect of a high-energy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid synthase

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5765079

The axis of mTOR-mitochondria-ROS and stemness of the hematopoietic stem cells

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5765079

Glucose metabolism heterogeneity in human and mouse malignant glioma cell lines

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5765079

The effects of metformin on the survival of colorectal cancer patients with diabetes mellitus

14 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FS41598-017-18762-4

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/S41598-017-18762-4

1 reference

6 February 2018

release_d77x7ah4cffobecgohxvbxysqu

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/d77x7ah4cffobecgohxvbxysqu

mapped directly with Wikidata item

24 November 2022

based on heuristic

PMC publication ID

5765079

1 reference

6 February 2018

PubMed publication ID

29323154

1 reference

6 February 2018