(Q47878854)

English

A death receptor 6-amyloid precursor protein pathway regulates synapse density in the mature CNS but does not contribute to Alzheimer's disease-related pathophysiology in murine models.

scientific article published in May 2014

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24806669%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

A death receptor 6-amyloid precursor protein pathway regulates synapse density in the mature CNS but does not contribute to Alzheimer's disease-related pathophysiology in murine models (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24806669%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Alzheimer's disease

0 references

pathophysiology

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

Marc Tessier-Lavigne

9

object named as

Marc Tessier-Lavigne

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24806669%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

author name string

Dara Y Kallop

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24806669%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

William J Meilandt

2

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24806669%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Alvin Gogineni

3

1 reference

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17 March 2020

Courtney Easley-Neal

4

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17 March 2020

Tiffany Wu

5

1 reference

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17 March 2020

Adrian M Jubb

6

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24806669%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Murat Yaylaoglu

7

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24806669%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Mehrdad Shamloo

8

1 reference

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17 March 2020

Kimberly Scearce-Levie

10

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24806669%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Robby M Weimer

11

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24806669%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

language of work or name

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publication date

1 May 2014

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17 March 2020

Journal of Neuroscience

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24806669%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

34

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17 March 2020

19

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24806669%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

6425-6437

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24806669%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Age-related cognitive deficits, impaired long-term potentiation and reduction in synaptic marker density in mice lacking the beta-amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/24806669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP

1 reference

https://pubmed.ncbi.nlm.nih.gov/24806669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Screening for PS1 mutations in a referral-based series of AD cases: 21 novel mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/24806669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A founder mutation in presenilin 1 causing early-onset Alzheimer disease in unrelated Caribbean Hispanic families

1 reference

https://pubmed.ncbi.nlm.nih.gov/24806669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired c-Jun amino terminal kinase activity and T cell differentiation in death receptor 6-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/24806669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Early formation of mature amyloid-beta protein deposits in a mutant APP transgenic model depends on levels of Abeta(1-42).

1 reference

https://pubmed.ncbi.nlm.nih.gov/24806669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapidly maturing variants of the Discosoma red fluorescent protein (DsRed).

1 reference

https://pubmed.ncbi.nlm.nih.gov/24806669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor necrosis factor-alpha induces the expression of DR6, a member of the TNF receptor family, through activation of NF-kappaB

1 reference

https://pubmed.ncbi.nlm.nih.gov/24806669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficient gene transfer into the embryonic mouse brain using in vivo electroporation

1 reference

https://pubmed.ncbi.nlm.nih.gov/24806669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative

1 reference

https://pubmed.ncbi.nlm.nih.gov/24806669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PS2APP transgenic mice, coexpressing hPS2mut and hAPPswe, show age-related cognitive deficits associated with discrete brain amyloid deposition and inflammation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24806669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Axon retraction and degeneration in development and disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/24806669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synapse Formation and Function Is Modulated by the Amyloid Precursor Protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/24806669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid redistribution of synaptic PSD-95 in the neocortex in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/24806669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinicopathological concordance and discordance in three monozygotic twin pairs with familial Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/24806669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24806669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid precursor protein knockout mice show age-dependent deficits in passive avoidance learning.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24806669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1 reference

https://pubmed.ncbi.nlm.nih.gov/24806669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Active and passive immunotherapy for neurodegenerative disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/24806669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A quick and efficient approach for gene silencing by using triple putative microRNA-based short hairpin RNAs

1 reference

https://pubmed.ncbi.nlm.nih.gov/24806669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of transgenic APP mRNA is the key determinant for beta-amyloid deposition in PS2APP transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24806669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

1 reference

https://pubmed.ncbi.nlm.nih.gov/24806669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

1 reference

https://pubmed.ncbi.nlm.nih.gov/24806669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term, high-resolution imaging in the mouse neocortex through a chronic cranial window

1 reference

https://pubmed.ncbi.nlm.nih.gov/24806669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gamma-secretase inhibition reduces spine density in vivo via an amyloid precursor protein-dependent pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24806669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid beta from axons and dendrites reduces local spine number and plasticity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24806669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

APP processing in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/24806669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Robust amyloid clearance in a mouse model of Alzheimer's disease provides novel insights into the mechanism of amyloid-beta immunotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/24806669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of breeding protocol in C57BL/6J mice on adult offspring behaviour

1 reference

https://pubmed.ncbi.nlm.nih.gov/24806669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease: the challenge of the second century

1 reference

https://pubmed.ncbi.nlm.nih.gov/24806669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A therapeutic antibody targeting BACE1 inhibits amyloid-β production in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/24806669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rare variants in APP, PSEN1 and PSEN2 increase risk for AD in late-onset Alzheimer's disease families

1 reference

https://pubmed.ncbi.nlm.nih.gov/24806669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Death receptors DR6 and TROY regulate brain vascular development

1 reference

https://pubmed.ncbi.nlm.nih.gov/24806669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thy1-hAPP(Lond/Swe+) mouse model of Alzheimer's disease displays broad behavioral deficits in sensorimotor, cognitive and social function

1 reference

https://pubmed.ncbi.nlm.nih.gov/24806669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In situ validation of an intestinal stem cell signature in colorectal cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/24806669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

1 reference

https://pubmed.ncbi.nlm.nih.gov/24806669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A caspase cascade regulating developmental axon degeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/24806669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A DR6/p75(NTR) complex is responsible for β-amyloid-induced cortical neuron death

1 reference

https://pubmed.ncbi.nlm.nih.gov/24806669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24806669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

EGFR inhibitor erlotinib delays disease progression but does not extend survival in the SOD1 mouse model of ALS

1 reference

https://pubmed.ncbi.nlm.nih.gov/24806669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Death receptor 6 regulates adult experience-dependent cortical plasticity

1 reference

https://pubmed.ncbi.nlm.nih.gov/24806669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic analysis reveals that amyloid precursor protein and death receptor 6 function in the same pathway to control axonal pruning independent of β-secretase

1 reference

https://pubmed.ncbi.nlm.nih.gov/24806669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/24806669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estimation of the Genetic Contribution of Presenilin-1 and -2 Mutations in a Population-Based Study of Presenile Alzheimer Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/24806669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification and functional characterization of DR6, a novel death domain-containing TNF receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/24806669

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.4963-13.2014

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24806669%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24806669%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24806669%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

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