(Q47884524)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25251193%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

title

Several human cyclin-dependent kinase inhibitors, structurally related to roscovitine, are new anti-malarial agents (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25251193%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

0 references

4

Jacques Le Bras

1 reference

PubMed publication ID

25251193

6 February 2018

http://europepmc.org/abstract/MED/25251193

Sandrine Houzé

1

object named as

Sandrine Houzé

1 reference

PubMed publication ID

25251193

6 February 2018

http://europepmc.org/abstract/MED/25251193

Laurent Meijer

5

object named as

Laurent Meijer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25251193%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

author name string

Nha-Thu Hoang

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25251193%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Olivier Lozach

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25251193%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Hervé Galons

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25251193%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Luc Demange

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25251193%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Sandrine Houzé

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25251193%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Jacques Le Bras

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25251193%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

language of work or name

English

0 references

publication date

23 September 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25251193%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25251193%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

volume

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25251193%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

issue

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25251193%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

page(s)

15237-15257

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25251193%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

19 February 2020

copyright license

start time

23 September 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Sequence-based association and selection scans identify drug resistance loci in the Plasmodium falciparum malaria parasite

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

Artemisinin-resistant malaria: research challenges, opportunities, and public health implications

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

In vitro and in vivo activity of solithromycin (CEM-101) against Plasmodium species

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

Inhibitors of the mitochondrial electron transport chain and de novo pyrimidine biosynthesis as antimalarials: The present status

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

Recent results in protein kinase inhibition for tropical diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

Protein kinases as targets for anti-parasitic chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

Protein kinases as targets for antimalarial intervention: Kinomics, structure-based design, transmission-blockade, and targeting host cell enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

Antimalarial drug discovery: targeting protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

Synthesis of carbocyclic pyrimidine nucleosides and their inhibitory activities against Plasmodium falciparum thymidylate kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

The malaria parasite cyclic GMP-dependent protein kinase plays a central role in blood-stage schizogony

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

Substituted imidazopyridazines are potent and selective inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1).

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

Optimization of an imidazopyridazine series of inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1).

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

Mammalian cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

Cyclin-dependent kinases: a family portrait.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

Cell cycle, CDKs and cancer: a changing paradigm

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

Cellular control of gene expression by T-type cyclin/CDK9 complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

Cdk5 deregulation in the pathogenesis of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

Cdk5 protein inhibition and Aβ42 increase BACE1 protein level in primary neurons by a post-transcriptional mechanism: implications of CDK5 as a therapeutic target for Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

A Cdk5 inhibitor enhances the induction of insulin secretion by exendin-4 both in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

Pharmacological inhibitors of cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

Plasmodium falciparum protein kinase 5 and the malarial nuclear division cycles

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

Pfmrk, a MO15-related protein kinase from Plasmodium falciparum. Gene cloning, sequence, stage-specific expression and chromosome localization

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

Influence of human p16(INK4) and p21(CIP1) on the in vitro activity of recombinant Plasmodium falciparum cyclin-dependent protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

Activation of a Plasmodium falciparum cdc2-related kinase by heterologous p25 and cyclin H. Functional characterization of a P. falciparum cyclin homologue

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

Leishmania MAP kinases--familiar proteins in an unusual context

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

Oxindole-based compounds are selective inhibitors of Plasmodium falciparum cyclin dependent protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

Structures of P. falciparum PfPK5 test the CDK regulation paradigm and suggest mechanisms of small molecule inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

A three-dimensional in silico pharmacophore model for inhibition of Plasmodium falciparum cyclin-dependent kinases and discovery of different classes of novel Pfmrk specific inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

Selective inhibition of Pfmrk, a Plasmodium falciparum CDK, by antimalarial 1,3-diaryl-2-propenones

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

Evaluation of broad spectrum protein kinase inhibitors to probe the architecture of the malarial cyclin dependent protein kinase Pfmrk

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

The purines: potent and versatile small molecule inhibitors and modulators of key biological targets

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

The purinome, a complex mix of drug and toxicity targets

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

Roscovitine and other purines as kinase inhibitors. From starfish oocytes to clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

Roscovitine targets, protein kinases and pyridoxal kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

The selectivity of protein kinase inhibitors: a further update

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

Roscovitine-derived, dual-specificity inhibitors of cyclin-dependent kinases and casein kinases 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

Potent inhibitors of CDK5 derived from roscovitine: synthesis, biological evaluation and molecular modelling

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

Crystal structure of pyridoxal kinase in complex with roscovitine and derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

Docking-Based Development of Purine-like Inhibitors of Cyclin-Dependent Kinase-2

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

An unusual member of the Cdk family: Cdk5.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

Tumor necrosis factor-alpha regulates cyclin-dependent kinase 5 activity during pain signaling through transcriptional activation of p35.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

Cdk5-dependent regulation of glucose-stimulated insulin secretion.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

A novel pyrazolo[1,5-a]pyrimidine is a potent inhibitor of cyclin-dependent protein kinases 1, 2, and 9, which demonstrates antitumor effects in human tumor xenografts following oral administration

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

Structure-activity relationship study of 2,4-diaminothiazoles as Cdk5/p25 kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

Studying synergism of methyl linked cyclohexyl thiophenes with triazole: synthesis and their cdk5/p25 inhibition activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

Regulation of Alzheimer's disease amyloid-beta formation by casein kinase I

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

Protein kinases CK1 and CK2 as new targets for neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

The role of DYRK1A in neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

Recent advances in the design, synthesis, and biological evaluation of selective DYRK1A inhibitors: a new avenue for a disease modifying treatment of Alzheimer's?

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

Leucettines, a class of potent inhibitors of cdc2-like kinases and dual specificity, tyrosine phosphorylation regulated kinases derived from the marine sponge leucettamine B: modulation of alternative pre-RNA splicing.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

Synthesis of chromeno[3,4-b]indoles as Lamellarin D analogues: a novel DYRK1A inhibitor class.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

Synthesis and optimization of an original V-shaped collection of 4-7-disubstituted pyrido[3,2-d]pyrimidines as CDK5 and DYRK1A inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

Pharmacophore and 3D-QSAR characterization of 6-arylquinazolin-4-amines as Cdc2-like kinase 4 (Clk4) and dual specificity tyrosine-phosphorylation-regulated kinase 1A (Dyrk1A) inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

Design, synthesis, and molecular modelling of pyridazinone and phthalazinone derivatives as protein kinases inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

Structure-activity relationships and inhibitory effects of various purine derivatives on the in vitro growth of Plasmodium falciparum.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

Anti-malarial activity of N6-modified purine analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

Synthesis and in vitro evaluation of novel 2,6,9-trisubstituted purines acting as cyclin-dependent kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

Assessment of the drug susceptibility of Plasmodium falciparum clinical isolates from africa by using a Plasmodium lactate dehydrogenase immunodetection assay and an inhibitory maximum effect model for precise measurement of the 50-percent inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES190915237

PfPK6, a novel cyclin-dependent kinase/mitogen-activated protein kinase-related protein kinase from Plasmodium falciparum

21 January 2018

1 reference

12 December 2020

Purification of GSK-3 by affinity chromatography on immobilized axin

1 reference

12 December 2020

Biology of man-mosquito Plasmodium transmission

1 reference

12 December 2020

The role of cyclin-dependent kinases in apoptosis.

1 reference

12 December 2020

Selective palladium-catalyzed arylation of ammonia: synthesis of anilines as well as symmetrical and unsymmetrical di- and triarylamines

1 reference

12 December 2020

[Cell cycle and molecular targets: CDK inhibition].

1 reference

12 December 2020

Potent inhibitors of malarial aspartic proteases, the plasmepsins, by hydroformylation of substituted 7-azanorbornenes

1 reference

12 December 2020

Acridone alkaloids from Glycosmis chlorosperma as DYRK1A inhibitors

1 reference

12 December 2020

10.3390/MOLECULES190915237

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25251193%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25251193%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

PubMed publication ID

25251193

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25251193%20AND%20SRC:MED&resulttype=core&format=json