(Q47893021)

6 February 2018

review article

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title

Polycomb Repressive Complex 2: Emerging Roles in the Central Nervous System. (English)

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6 February 2018

author name string

Pei-Pei Liu

1

1 reference

6 February 2018

Ya-Jie Xu

2

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6 February 2018

Zhao-Qian Teng

3

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6 February 2018

Chang-Mei Liu

4

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6 February 2018

publication date

1 December 2017

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6 February 2018

published in

The Neuroscientist

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6 February 2018

page(s)

1073858417747839

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6 February 2018

BMI1 sustains human glioblastoma multiforme stem cell renewal

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Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2.

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The roles and regulation of Polycomb complexes in neural development

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EZH2 inhibition: targeting the crossroad of tumor invasion and angiogenesis

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Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation

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PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies

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Interplay between H1 and HMGN epigenetically regulates OLIG1&2 expression and oligodendrocyte differentiation.

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Transcriptional regulation by Polycomb group proteins

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Ezh2 orchestrates topographic migration and connectivity of mouse precerebellar neurons

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REST-mediated recruitment of polycomb repressor complexes in mammalian cells

21 January 2018

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The Role of H3K4me3 in Transcriptional Regulation Is Altered in Huntington's Disease

21 January 2018

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Aberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma.

21 January 2018

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Chd8 mediates cortical neurogenesis via transcriptional regulation of cell cycle and Wnt signaling

21 January 2018

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Polycomb Ezh2 controls the fate of GABAergic neurons in the embryonic cerebellum

21 January 2018

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Polycomb-dependent H3K27me1 and H3K27me2 regulate active transcription and enhancer fidelity

21 January 2018

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Mediator complex cooperatively regulates transcription of retinoic acid target genes with Polycomb Repressive Complex 2 during neuronal differentiation

21 January 2018

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Polycomb group protein displacement and gene activation through MSK-dependent H3K27me3S28 phosphorylation

21 January 2018

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Mutations in EZH2 cause Weaver syndrome

21 January 2018

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Early activation of nSMase2/ceramide pathway in astrocytes is involved in ischemia-associated neuronal damage via inflammation in rat hippocampi

21 January 2018

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Spatial and temporal specification of neural fates by transcription factor codes.

21 January 2018

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Targeting EZH2 for cancer therapy: progress and perspective.

21 January 2018

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lncRNA Functional Networks in Oligodendrocytes Reveal Stage-Specific Myelination Control by an lncOL1/Suz12 Complex in the CNS

21 January 2018

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https://api.crossref.org/works/10.1177%2F1073858417747839

Histone methyltransferase enhancer of zeste homolog 2 regulates Schwann cell differentiation

21 January 2018

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https://api.crossref.org/works/10.1177%2F1073858417747839

Ezh1 and Ezh2 differentially regulate PSD-95 gene transcription in developing hippocampal neurons

21 January 2018

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https://api.crossref.org/works/10.1177%2F1073858417747839

Polycomb limits the neurogenic competence of neural precursor cells to promote astrogenic fate transition.

21 January 2018

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Distinct and separable roles for EZH2 in neurogenic astroglia

21 January 2018

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Mutations in genes encoding polycomb repressive complex 2 subunits cause Weaver syndrome

21 January 2018

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ATXR5 and ATXR6 are H3K27 monomethyltransferases required for chromatin structure and gene silencing.

21 January 2018

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H3K27me1 is E(z) in animals, but not in plants

21 January 2018

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Roles of H3K27me2 and H3K27me3 Examined during Fate Specification of Embryonic Stem Cells

21 January 2018

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Subunit contributions to histone methyltransferase activities of fly and worm polycomb group complexes

21 January 2018

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21 January 2018

Targeting EZH2 in cancer

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Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation

21 January 2018

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Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators.

21 January 2018

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Genome-wide activities of Polycomb complexes control pervasive transcription

21 January 2018

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Control of developmental regulators by Polycomb in human embryonic stem cells

21 January 2018

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Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma

21 January 2018

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Jarid2 and PRC2, partners in regulating gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

Polycomb-like proteins link the PRC2 complex to CpG islands.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

EZH2-mediated H3K27 trimethylation mediates neurodegeneration in ataxia-telangiectasia

21 January 2018

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https://api.crossref.org/works/10.1177%2F1073858417747839

The role of epigenomics in the neurodegeneration of ataxia-telangiectasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

Epigenetic regulation of oligodendrocyte identity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

Chromatin landscape defined by repressive histone methylation during oligodendrocyte differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

MiR-203 Interplays with Polycomb Repressive Complexes to Regulate the Proliferation of Neural Stem/Progenitor Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

Regulation of Peripheral Nerve Myelin Maintenance by Gene Repression through Polycomb Repressive Complex 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

The Polycomb complex PRC2 and its mark in life

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

A microarray-based DNA methylation study of glioblastoma multiforme

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

Haploinsufficiency of the murine polycomb gene Suz12 results in diverse malformations of the brain and neural tube.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

The murine polycomb group protein Eed is required for global histone H3 lysine-27 methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

Histone methyltransferase activity of a Drosophila Polycomb group repressor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

Pcl-PRC2 is needed to generate high levels of H3-K27 trimethylation at Polycomb target genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

The polycomb-group gene Ezh2 is required for early mouse development

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

Neuronal activity controls Bdnf expression via Polycomb de-repression and CREB/CBP/JMJD3 activation in mature neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

Histone trimethylation and the maintenance of transcriptional ON and OFF states by trxG and PcG proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

The polycomb group protein Suz12 is required for embryonic stem cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

The Polycomb group protein EED couples TNF receptor 1 to neutral sphingomyelinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

NFIB-mediated repression of the epigenetic factor Ezh2 regulates cortical development

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

Epigenetic balance of gene expression by Polycomb and COMPASS families

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

Polycomb controls gliogenesis by regulating the transient expression of the Gcm/Glide fate determinant

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

Coordinated regulation of dendrite arborization by epigenetic factors CDYL and EZH2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

The dynamics of polycomb group proteins in early embryonic nervous system in mouse and human

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

Immune function genes CD99L2, JARID2 and TPO show association with autism spectrum disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

Transcriptional Response of Polycomb Group Genes to Status Epilepticus in Mice is Modified by Prior Exposure to Epileptic Preconditioning.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

The polycomb group protein EED interacts with YY1, and both proteins induce neural tissue in Xenopus embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

Recruitment of Drosophila Polycomb-group proteins by Polycomblike, a component of a novel protein complex in larvae.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

Ezh2 is required for neural crest-derived cartilage and bone formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

Huntingtin facilitates polycomb repressive complex 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

Dynamic changes in Ezh2 gene occupancy underlie its involvement in neural stem cell self-renewal and differentiation towards oligodendrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

Dopamine signaling leads to loss of Polycomb repression and aberrant gene activation in experimental parkinsonism

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

The chromodomain helicase Chd4 is required for Polycomb-mediated inhibition of astroglial differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

The Arginine Methyltransferase PRMT6 Cooperates with Polycomb Proteins in Regulating HOXA Gene Expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

Patterns of histone H3 lysine 27 monomethylation and erythroid cell type-specific gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

Polycomb group protein ezh2 controls actin polymerization and cell signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

Gene trap capture of a novel mouse gene, jumonji, required for neural tube formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

The Histone H3K27 Demethylase UTX Regulates Synaptic Plasticity and Cognitive Behaviors in Mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

Germline mutations in the oncogene EZH2 cause Weaver syndrome and increased human height.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

Weaver syndrome and EZH2 mutations: Clarifying the clinical phenotype.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

The development of neural stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

Snail2/Slug cooperates with Polycomb repressive complex 2 (PRC2) to regulate neural crest development

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

EZH2 mutation in an adolescent with Weaver syndrome developing acute myeloid leukemia and secondary hemophagocytic lymphohistiocytosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

Profile of histone lysine methylation across transcribed mammalian chromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

Role of PRC2-associated factors in stem cells and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

Polycomb repressive complex 2 (PRC2) silences genes responsible for neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

Decreased Methylation Level of H3K27me3 Increases Seizure Susceptibility.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

A new overgrowth syndrome with accelerated skeletal maturation, unusual facies, and camptodactyly

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

Loss of Ezh2 promotes a midbrain-to-forebrain identity switch by direct gene derepression and Wnt-dependent regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

Ezh2 regulates adult hippocampal neurogenesis and memory.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

Somatic mutations of SUZ12 in malignant peripheral nerve sheath tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

Ezh2 is involved in radial neuronal migration through regulating Reelin expression in cerebral cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

Lack of CUL4B leads to increased abundance of GFAP-positive cells that is mediated by PTGDS in mouse brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

Erratum: Positional cloning of a global regulator of anterior–posterior patterning in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1073858417747839

21 January 2018

Identifiers

DOI

10.1177/1073858417747839

1 reference

6 February 2018

PubMed ID

29283025

1 reference

6 February 2018