(Q48031305)

7 February 2018

title

Structural and functional characterization of Falcipain-2, a hemoglobinase from the malarial parasite Plasmodium falciparum (English)

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7 February 2018

main subject

Plasmodium falciparum

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5

Xu Shen

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7 February 2018

Christoph J Blohmke

8

object named as

Christoph Blohmke

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7 February 2018

Rolf Hilgenfeld

9

object named as

Rolf Hilgenfeld

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7 February 2018

author name string

Tanis Hogg

1

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7 February 2018

Krishna Nagarajan

2

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7 February 2018

Saskia Herzberg

3

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7 February 2018

Lili Chen

4

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7 February 2018

Hualiang Jiang

6

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7 February 2018

Maria Wecke

7

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7 February 2018

Christian L Schmidt

10

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7 February 2018

language of work or name

English

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publication date

15 June 2006

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7 February 2018

Journal of Biological Chemistry

published in

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7 February 2018

volume

281

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7 February 2018

issue

35

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7 February 2018

page(s)

25425-25437

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7 February 2018

Primaquine therapy for malaria

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Structure and inhibition of plasmepsin II, a hemoglobin-degrading enzyme from Plasmodium falciparum

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Identification of three stage-specific proteinases of Plasmodium falciparum

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A malarial cysteine proteinase is necessary for hemoglobin degradation by Plasmodium falciparum

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Systematic optimization of expression and refolding of the Plasmodium falciparum cysteine protease falcipain-2.

21 January 2018

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Characterization of amino acid variation at strategic positions in parasite and human proteases for selective inhibition of falcipains in Plasmodium falciparum

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Plasmodium falciparum cysteine protease falcipain-2 cleaves erythrocyte membrane skeletal proteins at late stages of parasite development

21 January 2018

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Characterization of native and recombinant falcipain-2, a principal trophozoite cysteine protease and essential hemoglobinase of Plasmodium falciparum

21 January 2018

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Biosynthesis, localization, and processing of falcipain cysteine proteases of Plasmodium falciparum

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Folding of the Plasmodium falciparum cysteine protease falcipain-2 is mediated by a chaperone-like peptide and not the prodomain

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Gene disruption confirms a critical role for the cysteine protease falcipain-2 in hemoglobin hydrolysis by Plasmodium falciparum

21 January 2018

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A role for the protease falcipain 1 in host cell invasion by the human malaria parasite

21 January 2018

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Targeted disruption of Plasmodium falciparum cysteine protease, falcipain 1, reduces oocyst production, not erythrocytic stage growth

21 January 2018

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The Plasmodium falciparum cysteine protease falcipain-2 captures its substrate, hemoglobin, via a unique motif

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Synthesis and antiplasmodial activity of a cysteine protease-inhibiting biotinylated aziridine-2,3-dicarboxylate

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Protein Identification and Analysis Tools on the ExPASy Server

21 January 2018

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The integration of macromolecular diffraction data

21 January 2018

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Scaling and assessment of data quality

21 January 2018

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The CCP4 suite: programs for protein crystallography

21 January 2018

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Likelihood-enhanced fast rotation functions

21 January 2018

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The importance of alignment accuracy for molecular replacement.

21 January 2018

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The 2.0 A crystal structure and substrate specificity of the KDEL-tailed cysteine endopeptidase functioning in programmed cell death of Ricinus communis endosperm

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The crystal structure of cruzain: a therapeutic target for Chagas' disease

21 January 2018

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A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease

21 January 2018

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Crystal structures of reversible ketone-Based inhibitors of the cysteine protease cruzain

21 January 2018

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Homology modeling and mutagenesis analyses of Plasmodium falciparum falcipain 2A: implications for rational drug design

21 January 2018

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21 January 2018

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21 January 2018

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Plasmodium berghei resists killing by reactive oxygen species

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Ankyrin peptide blocks falcipain-2-mediated malaria parasite release from red blood cells

21 January 2018

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Structure of papain refined at 1.65 A resolution

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M603776200

The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603776200

Stereochemical quality of protein structure coordinates

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603776200

21 January 2018

Identifiers

DOI

10.1074/JBC.M603776200

1 reference

7 February 2018

1 reference

7 February 2018