(Q48095662)

8 February 2018

title

BRCA-deficient mouse mammary tumor organoids to study cancer-drug resistance (English)

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8 February 2018

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3

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8 February 2018

Marco Barazas

Marco Barazas

4

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Arno Velds

Arno Velds

7

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Sven Rottenberg

Sven Rottenberg

14

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Hans Clevers

11

Hans Clevers

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8 February 2018

author name string

Alexandra A Duarte

1

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8 February 2018

Ewa Gogola

2

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8 February 2018

Stefano Annunziato

5

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8 February 2018

Julian R de Ruiter

6

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8 February 2018

Sohvi Blatter

8

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8 February 2018

Julia M Houthuijzen

9

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8 February 2018

Marieke van de Ven

10

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8 February 2018

Piet Borst

12

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8 February 2018

Jos Jonkers

13

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8 February 2018

publication date

11 December 2017

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8 February 2018

published in

Nature Methods

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8 February 2018

volume

15

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8 February 2018

issue

2

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8 February 2018

page(s)

134-140

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8 February 2018

https://scigraph.springernature.com/pub.10.1038/nmeth.4535

exact match

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cites work

Somatic loss of BRCA1 and p53 in mice induces mammary tumors with features of human BRCA1-mutated basal-like breast cancer

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Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.

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Drug resistance in the mouse cancer clinic

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Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer

21 January 2018

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High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs

21 January 2018

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Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors

21 January 2018

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BRCA2-deficient sarcomatoid mammary tumors exhibit multidrug resistance.

21 January 2018

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REV7 counteracts DNA double-strand break resection and affects PARP inhibition

21 January 2018

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HELB Is a Feedback Inhibitor of DNA End Resection

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Replication fork stability confers chemoresistance in BRCA-deficient cells

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Selective inhibition of BRCA2-deficient mammary tumor cell growth by AZD2281 and cisplatin.

21 January 2018

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Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

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Hallmarks of 'BRCAness' in sporadic cancers

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Landscape of somatic mutations in 560 breast cancer whole-genome sequences

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A synthetic lethal therapeutic approach: poly(ADP) ribose polymerase inhibitors for the treatment of cancers deficient in DNA double-strand break repair

21 January 2018

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53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

21 January 2018

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53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks

21 January 2018

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Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients

21 January 2018

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Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids.

21 January 2018

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Sequential cancer mutations in cultured human intestinal stem cells.

21 January 2018

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Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids

21 January 2018

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Easy quantitative assessment of genome editing by sequence trace decomposition

21 January 2018

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Genetic Dissection of Cancer Development, Therapy Response, and Resistance in Mouse Models of Breast Cancer

21 January 2018

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Efficacy of chemotherapy in BRCA1/2 mutation carrier ovarian cancer in the setting of PARP inhibitor resistance: a multi-institutional study

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Whole-genome characterization of chemoresistant ovarian cancer.

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A Biobank of Breast Cancer Explants with Preserved Intra-tumor Heterogeneity to Screen Anticancer Compounds

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Screening out irrelevant cell-based models of disease.

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The role of tumour-stromal interactions in modifying drug response: challenges and opportunities

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Collective epithelial migration and cell rearrangements drive mammary branching morphogenesis

21 January 2018

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Adenovirus-Mediated Somatic Genome Editing of Pten by CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses.

21 January 2018

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Modeling invasive lobular breast carcinoma by CRISPR/Cas9-mediated somatic genome editing of the mammary gland

21 January 2018

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21 January 2018

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PTPN11 Is a Central Node in Intrinsic and Acquired Resistance to Targeted Cancer Drugs

21 January 2018

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Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequences

21 January 2018

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Controlled gene expression in primary Lgr5 organoid cultures

21 January 2018

1 reference

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21 January 2018

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Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNMETH.4535

inferred from DOI database lookup

7 January 2021

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Identifiers

DOI

10.1038/NMETH.4535

1 reference

8 February 2018

1 reference

8 February 2018