(Q38085500)

28 August 2017

title

The role of tumour-stromal interactions in modifying drug response: challenges and opportunities (English)

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28 August 2017

Douglas W McMillin

1

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28 August 2017

Joseph M Negri

series ordinal

2

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28 August 2017

Constantine S Mitsiades

series ordinal

3

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28 August 2017

language of work or name

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1 March 2013

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Nature Reviews Drug Discovery

28 August 2017

published in

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28 August 2017

volume

12

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28 August 2017

issue

3

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28 August 2017

page(s)

217-228

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Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing

28 August 2017

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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The landscape of somatic copy-number alteration across human cancers

31 March 2020

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Functional genomics identifies therapeutic targets for MYC-driven cancer

31 March 2020

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Biologic characteristics of bone marrow mesenchymal stem cells in myelodysplastic syndromes.

31 March 2020

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How the microenvironment shapes chronic lymphocytic leukemia: the cytoskeleton connection

31 March 2020

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Generation of phenotypic diversity and progression in metastatic tumor cells

31 March 2020

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Plasticity of the neoplastic phenotype in vivo is regulated by epigenetic factors

31 March 2020

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Tumour-stromal interactions. Integrins and cell adhesions as modulators of mammary cell survival and transformation.

31 March 2020

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Distinct epigenetic changes in the stromal cells of breast cancers

31 March 2020

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Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basal-like breast cancers

31 March 2020

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Discovery and characterization of novel mutant FLT3 kinase inhibitors

31 March 2020

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Wounding and its role in RSV-mediated tumor formation

31 March 2020

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31 March 2020

Inflammation and cancer

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The unholy trinity: inflammation, cytokines, and STAT3 shape the cancer microenvironment

31 March 2020

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Matrix metalloproteinases as master regulators of the vicious cycle of bone metastasis

31 March 2020

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The state of innovation in drug development

31 March 2020

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Can the pharmaceutical industry reduce attrition rates?

31 March 2020

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Economics of new oncology drug development

31 March 2020

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Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance

31 March 2020

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Modeling and predicting clinical efficacy for drugs targeting the tumor milieu

31 March 2020

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Cancer metastasis: building a framework

31 March 2020

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Tumor metastasis: mechanistic insights and clinical challenges

31 March 2020

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Tumor metastasis: molecular insights and evolving paradigms

31 March 2020

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The metastatic niche and stromal progression

31 March 2020

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Anti-VEGF antibody therapy does not promote metastasis in genetically engineered mouse tumour models

31 March 2020

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Mouse models of advanced spontaneous metastasis for experimental therapeutics

31 March 2020

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Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment

31 March 2020

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Does tumour dormancy offer a therapeutic target?

31 March 2020

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Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors

31 March 2020

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BET bromodomain inhibition as a therapeutic strategy to target c-Myc

31 March 2020

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AID-dependent activation of a MYC transgene induces multiple myeloma in a conditional mouse model of post-germinal center malignancies.

31 March 2020

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Drug response in a genetically engineered mouse model of multiple myeloma is predictive of clinical efficacy

31 March 2020

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MLL-AF9 and FLT3 cooperation in acute myelogenous leukemia: development of a model for rapid therapeutic assessment.

31 March 2020

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A mouse model of human breast cancer metastasis to human bone

31 March 2020

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Osteosclerotic prostate cancer metastasis to murine bone are enhanced with increased bone formation

31 March 2020

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Early detection of bone metastases in a murine model using fluorescent human breast cancer cells: application to the use of the bisphosphonate zoledronic acid in the treatment of osteolytic lesions

31 March 2020

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Denosumab and bone-metastasis-free survival in men with castration-resistant prostate cancer: results of a phase 3, randomised, placebo-controlled trial

31 March 2020

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Lapatinib and obatoclax kill tumor cells through blockade of ERBB1/3/4 and through inhibition of BCL-XL and MCL-1.

31 March 2020

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31 March 2020

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Sagopilone crosses the blood-brain barrier in vivo to inhibit brain tumor growth and metastases

31 March 2020

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Development of a preclinical model of spontaneous human melanoma central nervous system metastasis

31 March 2020

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31 March 2020

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Potentiation of antileukemic therapies by Smac mimetic, LBW242: effects on mutant FLT3-expressing cells

31 March 2020

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Siltuximab, a novel anti-interleukin-6 monoclonal antibody, for Castleman's disease

31 March 2020

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Interleukin-6/interleukin-6 receptor pathway as a new therapy target in epithelial ovarian cancer.

31 March 2020

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Paraneoplastic thrombocytosis in ovarian cancer.

31 March 2020

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A phase 1 study of a chimeric monoclonal antibody against interleukin-6, siltuximab, combined with docetaxel in patients with metastatic castration-resistant prostate cancer.

31 March 2020

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Implantation mechanisms: insights from the sheep.

31 March 2020

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Integrins: the keys to unlocking angiogenesis

31 March 2020

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31 March 2020

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31 March 2020

Antibodies in oncology

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Examining the Metastatic Niche: Targeting the Microenvironment

31 March 2020

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Protein therapeutics: a summary and pharmacological classification

31 March 2020

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Systematic identification of genomic markers of drug sensitivity in cancer cells

31 March 2020

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Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

31 March 2020

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Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer

31 March 2020

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New drugs for breast cancer subtypes: targeting driver pathways to overcome resistance

31 March 2020

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Third-generation tyrosine kinase inhibitors and beyond

31 March 2020

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Translational approaches targeting the p53 pathway for anti-cancer therapy

31 March 2020

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Are KRAS/BRAF mutations potent prognostic and/or predictive biomarkers in colorectal cancers?

31 March 2020

1 reference

Melanoma whole-exome sequencing identifies (V600E)B-RAF amplification-mediated acquired B-RAF inhibitor resistance

31 March 2020

1 reference

RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)

31 March 2020

1 reference

COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

31 March 2020

1 reference

Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation

31 March 2020

1 reference

Putting tumours in context

31 March 2020

1 reference

Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression

31 March 2020

1 reference

Interactions between lymphocytes and myeloid cells regulate pro- versus anti-tumor immunity

31 March 2020

1 reference

The anticancer immune response: indispensable for therapeutic success?

31 March 2020

1 reference

Immune parameters affecting the efficacy of chemotherapeutic regimens

31 March 2020

1 reference

Compartment-Specific Bioluminescence Imaging platform for the high-throughput evaluation of antitumor immune function

31 March 2020

1 reference

Humanized mice in translational biomedical research

31 March 2020

1 reference

Current advances in humanized mouse models

31 March 2020

1 reference

Genomically humanized mice: technologies and promises

31 March 2020

1 reference

Reconstructing the human hematopoietic niche in immunodeficient mice: opportunities for studying primary multiple myeloma

31 March 2020

1 reference

Bortezomib or high-dose dexamethasone for relapsed multiple myeloma

31 March 2020

1 reference

Role of VAD in the initial treatment of multiple myeloma

31 March 2020

1 reference

Anaplastic thyroid cancer: a review of epidemiology, pathogenesis, and treatment

31 March 2020

1 reference

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

31 March 2020

1 reference

Improved survival with vemurafenib in melanoma with BRAF V600E mutation

31 March 2020

1 reference

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

31 March 2020

1 reference

Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib

31 March 2020

1 reference

Challenges facing JAK inhibitor therapy for myeloproliferative neoplasms.

31 March 2020

1 reference

The concept of synthetic lethality in the context of anticancer therapy

31 March 2020

1 reference

Recent advances in non-small cell lung cancer biology and clinical management.

31 March 2020

1 reference

12 December 2020

Influence of microenvironmental pH on adriamycin resistance.

1 reference

12 December 2020

Approval summary for zoledronic acid for treatment of multiple myeloma and cancer bone metastases.

1 reference

12 December 2020

Abnormal function of the bone marrow microenvironment in chronic myelogenous leukemia: role of malignant stromal macrophages.

1 reference

12 December 2020

Epigenetic regulation of gene expression in cervical cancer cells by the tumor microenvironment

1 reference

12 December 2020

Characterization of adhesion molecules on human myeloma cell lines

1 reference

12 December 2020

Clinical significance of interleukin (IL)-6 in cancer metastasis to bone: potential of anti-IL-6 therapies

1 reference

12 December 2020

Inflammation is responsible for the development of wound-induced tumors in chickens infected with Rous sarcoma virus.

1 reference

12 December 2020

The tumor-promoting effect of wounding: a possible role for TGF-beta-induced stromal alterations.

1 reference

12 December 2020

'Role of bone marrow stromal cells in the growth of human multiple myeloma

1 reference

12 December 2020

Thyroid cancer resistance to chemotherapeutic drugs via autocrine production of interleukin-4 and interleukin-10

1 reference

12 December 2020

Bisphosphonate risedronate reduces metastatic human breast cancer burden in bone in nude mice

1 reference

12 December 2020

Anticancer immunochemotherapy using adjuvants with direct cytotoxic effects

1 reference

12 December 2020

New druggable targets in the Ras pathway?

1 reference

12 December 2020

Evaluation of the cocarcinogenic effect of wounding in Rous sarcoma virus tumorigenesis

1 reference

12 December 2020

Role of organ selectivity in the determination of metastatic patterns of B16 melanoma.

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRD3870

1 reference

release_qtyblp6r5vhbfmwptve6xiy7ii

28 August 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/qtyblp6r5vhbfmwptve6xiy7ii

24 November 2022

mapped directly with Wikidata item

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