(Q48123992)

8 February 2018

title

BACE1 and mutated presenilin-1 differently modulate Abeta40 and Abeta42 levels and cerebral amyloidosis in APPDutch transgenic mice. (English)

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8 February 2018

author

Paolo Paganetti

2

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8 February 2018

Mathias Jucker

4

object named as

Mathias Jucker

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8 February 2018

Matthias Staufenbiel

3

object named as

Matthias Staufenbiel

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8 February 2018

author name string

Martin C Herzig

1

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8 February 2018

publication date

1 January 2007

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8 February 2018

Neurodegenerative Diseases

published in

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8 February 2018

volume

4

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8 February 2018

issue

2-3

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8 February 2018

page(s)

127-135

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8 February 2018

Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis.

cites work

1 reference

Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.

21 January 2018

1 reference

Abeta-generating enzymes: recent advances in beta- and gamma-secretase research

21 January 2018

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Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

21 January 2018

1 reference

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

21 January 2018

1 reference

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

21 January 2018

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Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

21 January 2018

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Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

21 January 2018

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

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Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

21 January 2018

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Expression of human beta-secretase in the mouse brain increases the steady-state level of beta-amyloid.

21 January 2018

1 reference

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

21 January 2018

1 reference

Transgenic BACE expression in mouse neurons accelerates amyloid plaque pathology

21 January 2018

1 reference

BACE overexpression alters the subcellular processing of APP and inhibits Abeta deposition in vivo

21 January 2018

1 reference

beta-site amyloid precursor protein cleaving enzyme 1 increases amyloid deposition in brain parenchyma but reduces cerebrovascular amyloid angiopathy in aging BACE x APP[V717I] double-transgenic mice

21 January 2018

1 reference

Altered amyloid-beta metabolism and deposition in genomic-based beta-secretase transgenic mice

21 January 2018

1 reference

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

21 January 2018

1 reference

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

21 January 2018

1 reference

Cerebral amyloid angiopathy: amyloid beta accumulates in putative interstitial fluid drainage pathways in Alzheimer's disease

21 January 2018

1 reference

Cerebral microvascular amyloid beta protein deposition induces vascular degeneration and neuroinflammation in transgenic mice expressing human vasculotropic mutant amyloid beta precursor protein

21 January 2018

1 reference

Electrophoretic Separation of βA4 Peptides (1–40) and (1–42)

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1159/000101837

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8 February 2018

PubMed ID

17596707

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8 February 2018