(Q48220372)

9 February 2018

title

A dual inhibitor of cyclooxygenase and 5-lipoxygenase protects against kainic acid-induced brain injury (English)

1 reference

9 February 2018

author

Federica Galfo

12

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9 February 2018

Monica Interdonato

Monica Interdonato

11

0 references

Margherita Calò

Margherita Calò

8

0 references

Herbert Marini

Herbert Marini

2

0 references

Elena Bianca Adamo

9

Elena Bianca Adamo

1 reference

9 February 2018

author name string

Letteria Minutoli

1

1 reference

9 February 2018

Mariagrazia Rinaldi

3

1 reference

9 February 2018

Alessandra Bitto

4

1 reference

9 February 2018

Natasha Irrera

5

1 reference

9 February 2018

Gabriele Pizzino

6

1 reference

9 February 2018

Giovanni Pallio

7

1 reference

9 February 2018

Vincenzo Trichilo

10

1 reference

9 February 2018

Francesco Squadrito

13

1 reference

9 February 2018

Domenica Altavilla

14

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9 February 2018

publication date

19 April 2015

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9 February 2018

published in

NeuroMolecular Medicine

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9 February 2018

volume

17

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9 February 2018

issue

2

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9 February 2018

page(s)

192-201

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9 February 2018

Effects of flavocoxid, a dual inhibitor of COX and 5-lipoxygenase enzymes, on benign prostatic hyperplasia.

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Flavocoxid, a dual inhibitor of cyclooxygenase and 5-lipoxygenase, blunts pro-inflammatory phenotype activation in endotoxin-stimulated macrophages

21 January 2018

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Cyclooxygenase-2 selective inhibitors aggravate kainic acid induced seizure and neuronal cell death in the hippocampus

21 January 2018

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Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy

21 January 2018

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Co-administration of acetyl-11-keto-beta-boswellic acid, a specific 5-lipoxygenase inhibitor, potentiates the protective effect of COX-2 inhibitors in kainic acid-induced neurotoxicity in mice

21 January 2018

1 reference

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Flavocoxid, a dual inhibitor of COX-2 and 5-LOX of natural origin, attenuates the inflammatory response and protects mice from sepsis

21 January 2018

1 reference

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Flavocoxid inhibits phospholipase A2, peroxidase moieties of the cyclooxygenases (COX), and 5-lipoxygenase, modifies COX-2 gene expression, and acts as an antioxidant

21 January 2018

1 reference

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A medicinal extract of Scutellaria baicalensis and Acacia catechu acts as a dual inhibitor of cyclooxygenase and 5-lipoxygenase to reduce inflammation

21 January 2018

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Peptidoglycan induces nuclear factor-kappaB activation and cyclooxygenase-2 expression via Ras, Raf-1, and ERK in RAW 264.7 macrophages

21 January 2018

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The Antiinflammatory and Analgesic Effects of Baicalin in Carrageenan-Evoked Thermal Hyperalgesia

21 January 2018

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Current lead natural products for the chemotherapy of human immunodeficiency virus (HIV) infection

21 January 2018

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Inhibitors of brain phospholipase A2 activity: their neuropharmacological effects and therapeutic importance for the treatment of neurologic disorders

21 January 2018

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Post-treatment, but not pre-treatment, with the selective cyclooxygenase-2 inhibitor celecoxib markedly enhances functional recovery from kainic acid-induced neurodegeneration.

21 January 2018

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Effects of SC58236, a selective COX-2 inhibitor, on epileptogenesis and spontaneous seizures in a rat model for temporal lobe epilepsy

21 January 2018

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Biological properties of baicalein in cardiovascular system

21 January 2018

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Ketogenic diet-induced peroxisome proliferator-activated receptor-γ activation decreases neuroinflammation in the mouse hippocampus after kainic acid-induced seizures

21 January 2018

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Cyclooxygenase-2 inhibitor, celecoxib, inhibits the altered hippocampal neurogenesis with attenuation of spontaneous recurrent seizures following pilocarpine-induced status epilepticus

21 January 2018

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Cyclooxygenase-2 expression is induced in rat brain after kainate-induced seizures and promotes neuronal death in CA3 hippocampus

21 January 2018

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Montelukast potentiates the protective effect of rofecoxib against kainic acid-induced cognitive dysfunction in rats

21 January 2018

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The selective cyclooxygenase-2 inhibitor rofecoxib reduces kainate-induced cell death in the rat hippocampus

21 January 2018

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Dual acting anti-inflammatory drugs.

21 January 2018

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Efficacy and safety of flavocoxid, a novel therapeutic, compared with naproxen: a randomized multicenter controlled trial in subjects with osteoarthritis of the knee.

21 January 2018

1 reference

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Kainate mediates nuclear factor-kappa B activation in hippocampus via phosphatidylinositol-3 kinase and extracellular signal-regulated protein kinase.

21 January 2018

1 reference

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5-Lipoxygenase and cyclooxygenase mRNA expression in rat hippocampus:early response to glutamate receptor activation by kainate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-015-8351-0

Modulation of IL-1 beta gene expression by lipid peroxidation inhibition after kainic acid-induced rat brain injury

21 January 2018

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Levetiracetam protects against kainic acid-induced toxicity

21 January 2018

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Excitotoxicity: bridge to various triggers in neurodegenerative disorders

21 January 2018

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Flavocoxid counteracts muscle necrosis and improves functional properties in mdx mice: a comparison study with methylprednisolone.

21 January 2018

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Flavocoxid, a dual inhibitor of cyclooxygenase‐2 and 5‐lipoxygenase, reduces pancreatic damage in an experimental model of acute pancreatitis

21 January 2018

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Modification of seizure activity by electrical stimulation. II. Motor seizure

21 January 2018

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21 January 2018

1 reference

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Flavocoxid, dual inhibitor of cyclooxygenase-2 and 5-lipoxygenase, exhibits neuroprotection in rat model of ischaemic stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-015-8351-0

Prostaglandin E2 produced by late induced COX-2 stimulates hippocampal neuron loss after seizure in the CA3 region

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-015-8351-0

Roles of prostaglandin synthesis in excitotoxic brain diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-015-8351-0

Intercellular signaling pathway among Endothelia, astrocytes and neurons in excitatory neuronal damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-015-8351-0

Kainate receptors in epilepsy and excitotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-015-8351-0

Hypothermia reduces brain edema, spontaneous recurrent seizure attack, and learning memory deficits in the kainic acid treated rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12017-015-8351-0

Kainic acid-mediated excitotoxicity as a model for neurodegeneration

21 January 2018

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Kainic Acid-induced neurotoxicity: targeting glial responses and glia-derived cytokines.

21 January 2018

1 reference

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Kainic acid-induced neurodegenerative model: potentials and limitations

21 January 2018

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The 5-lipoxygenase as a common pathway for pathological brain and vascular aging

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25893744

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Multiple actions of the coumarine derivative cloricromene and its protective effects on ischemic brain injury

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25893744

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1007/S12017-015-8351-0

1 reference

9 February 2018

1 reference

9 February 2018