(Q48224594)

9 February 2018

title

Canonical Notch signaling is not required for the growth of Hedgehog pathway-induced medulloblastoma (English)

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9 February 2018

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E Julian

1

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9 February 2018

R K Dave

2

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9 February 2018

J P Robson

3

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9 February 2018

A R Hallahan

4

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9 February 2018

B J Wainwright

5

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9 February 2018

language of work or name

English

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publication date

26 April 2010

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9 February 2018

published in

Oncogene

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9 February 2018

volume

29

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9 February 2018

issue

24

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9 February 2018

page(s)

3465-3476

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9 February 2018

https://scigraph.springernature.com/pub.10.1038/onc.2010.101

exact match

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cites work

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Cooperation between the Hic1 and Ptch1 tumor suppressors in medulloblastoma

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REN(KCTD11) is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma

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Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors

21 January 2018

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Notch1 and notch2 have opposite effects on embryonal brain tumor growth

21 January 2018

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BRCA2 is required for neurogenesis and suppression of medulloblastoma

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Transcription factor RBP-J-mediated signaling represses the differentiation of neural stem cells into intermediate neural progenitors

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MicroRNA-199b-5p impairs cancer stem cells through negative regulation of HES1 in medulloblastoma

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Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway

21 January 2018

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Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome

21 January 2018

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The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomas

21 January 2018

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Crossing paths with Notch in the hyper-network

21 January 2018

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Hes genes and neurogenin regulate non-neural versus neural fate specification in the dorsal telencephalic midline

21 January 2018

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Sonic Hedgehog regulates Hes1 through a novel mechanism that is independent of canonical Notch pathway signalling.

21 January 2018

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Patterns of Jagged1, Jagged2, Delta-like 1 and Delta-like 3 expression during late embryonic and postnatal brain development suggest multiple functional roles in progenitors and differentiated cells

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An obligatory role of mind bomb-1 in notch signaling of mammalian development

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Disruption of the PACAP gene promotes medulloblastoma in ptc1 mutant mice.

21 January 2018

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Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas

21 January 2018

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Notch signalling in vertebrate neural development

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Medulloblastoma: developmental mechanisms out of control

21 January 2018

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Target selectivity of vertebrate notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probability

21 January 2018

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21 January 2018

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Notch inhibitors as a new tool in the war on cancer: a pathway to watch

21 January 2018

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Sonic hedgehog and insulin-like growth factor signaling synergize to induce medulloblastoma formation from nestin-expressing neural progenitors in mice

21 January 2018

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21 January 2018

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21 January 2018

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Medulloblastoma: role of developmental pathways, DNA repair signaling, and other players.

21 January 2018

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Medulloblastomas derived from Cxcr6 mutant mice respond to treatment with a smoothened inhibitor.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2010.101

Shh pathway activity is down-regulated in cultured medulloblastoma cells: implications for preclinical studies

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2010.101

Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.101

Activated Notch2 signaling inhibits differentiation of cerebellar granule neuron precursors by maintaining proliferation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.101

Stem cell marker expression in the Bergmann glia population of the adult mouse brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.101

Notch1 and its ligands Delta-like and Jagged are expressed and active in distinct cell populations in the postnatal mouse brain.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2010.101

Notch signaling and diseases: an evolutionary journey from a simple beginning to complex outcomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.101

Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2010.101

PARP-1 cooperates with Ptc1 to suppress medulloblastoma and basal cell carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.101

Mutations in SUFU predispose to medulloblastoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.101

Patched1 deletion increases N-Myc protein stability as a mechanism of medulloblastoma initiation and progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.101

Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.101

Somatic mutations in the human homologue of Drosophila patched in primitive neuroectodermal tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.101

Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.101

Hedgehog to Hes1: the heist of a Notch target.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.101

Dysregulated Sonic hedgehog signaling and medulloblastoma consequent to IFN-alpha-stimulated STAT2-independent production of IFN-gamma in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.101

Jagged1 ablation results in cerebellar granule cell migration defects and depletion of Bergmann glia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.101

The hedgehog signalling pathway in tumorigenesis and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.101

Notch/RBP-J signaling regulates epidermis/hair fate determination of hair follicular stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.101

Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.101

Identification of differentially expressed and developmentally regulated genes in medulloblastoma using suppression subtraction hybridization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.101

hGFAP-cre transgenic mice for manipulation of glial and neuronal function in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.101

Genetic alterations in mouse medulloblastomas and generation of tumors de novo from primary cerebellar granule neuron precursors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.101

Identification of PATCHED mutations in medulloblastomas by direct sequencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.101

Notch/Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.101

The monolayer formation of Bergmann glial cells is regulated by Notch/RBP-J signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.101

Diagnosis, treatment, and outcome of primary central nervous system tumors of childhood.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.101

Notch 1 and 3 receptor signaling modulates vascular smooth muscle cell growth, apoptosis, and migration via a CBF-1/RBP-Jk dependent pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.101

31 March 2020

Identifiers

DOI

10.1038/ONC.2010.101

1 reference

9 February 2018

1 reference

9 February 2018