(Q48235281)

13 June 2018

title

WNK-SPAK-NCC cascade revisited: WNK1 stimulates the activity of the Na-Cl cotransporter via SPAK, an effect antagonized by WNK4. (English)

1 reference

13 June 2018

author

Emmanuelle Vidal-Petiot

6

1 reference

http://europepmc.org/abstract/MED/25113964

9 February 2018

David H. Ellison

14

1 reference

http://europepmc.org/abstract/MED/25113964

9 February 2018

Gerardo Gamba

15

1 reference

http://europepmc.org/abstract/MED/25113964

9 February 2018

Erika Moreno

Erika Moreno

4

0 references

Diana Pacheco-Alvarez

Diana Pacheco-Alvarez

5

0 references

María Castañeda-Bueno

María Castañeda-Bueno

7

0 references

Xavier Jeunemaitre

12

Xavier Jeunemaitre

1 reference

PMCID

5832045

Norma Elizabeth Vázquez-Herrera

13 June 2018

8

Norma Vázquez

1 reference

13 June 2018

Lorena Rojas-Vega

9

Lorena Rojas-Vega

1 reference

13 June 2018

Juliette Hadchouel

16

Juliette Hadchouel

1 reference

13 June 2018

author name string

María Chávez-Canales

1

1 reference

13 June 2018

Chong Zhang

2

1 reference

13 June 2018

Christelle Soukaseum

3

1 reference

13 June 2018

Nicholas P Meermeier

10

1 reference

13 June 2018

Shaunessy Rogers

11

1 reference

13 June 2018

Chao-Ling Yang

13

1 reference

13 June 2018

language of work or name

English

0 references

publication date

11 August 2014

1 reference

13 June 2018

published in

Hypertension

1 reference

13 June 2018

volume

64

1 reference

13 June 2018

issue

5

1 reference

13 June 2018

page(s)

1047-1053

1 reference

13 June 2018

Regulation of blood pressure and renal electrolyte balance by Cullin-RING ligases

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5832045

WNK4 is the major WNK positively regulating NCC in the mouse kidney

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5832045

Regulation of with-no-lysine kinase signaling by Kelch-like proteins

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5832045

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5832045

Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5832045

A minor role of WNK3 in regulating phosphorylation of renal NKCC2 and NCC co-transporters in vivo

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5832045

A new model of the distal convoluted tubule

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5832045

A new methodology for quantification of alternatively spliced exons reveals a highly tissue-specific expression pattern of WNK1 isoforms

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5832045

Disease-causing mutations in the acidic motif of WNK4 impair the sensitivity of WNK4 kinase to calcium ions

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5832045

SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5832045

Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5832045

WNK3 and WNK4 amino-terminal domain defines their effect on the renal Na+-Cl- cotransporter

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5832045

Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5832045

The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5832045

Regulation of the expression of the Na/Cl cotransporter by WNK4 and WNK1: evidence that accelerated dynamin-dependent endocytosis is not involved.

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5832045

WNK4 kinase regulates surface expression of the human sodium chloride cotransporter in mammalian cells

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5832045

WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5832045

WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5832045

The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5832045

Properties of WNK1 and implications for other family members

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5832045

Mechanisms of WNK1 and WNK4 interaction in the regulation of thiazide-sensitive NaCl cotransport

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5832045

WNK kinases regulate thiazide-sensitive Na-Cl cotransport

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5832045

Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5832045

Human hypertension caused by mutations in WNK kinases

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5832045

WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5832045

Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5832045

Loss of WNK3 is compensated for by the WNK1/SPAK axis in the kidney of the mouse

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5832045

WNK3-SPAK interaction is required for the modulation of NCC and other members of the SLC12 family.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5832045

Global noncommunicable diseases--where worlds meet

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5832045

Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule

14 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25113964

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1161/HYPERTENSIONAHA.114.04036

1 reference

13 June 2018

PMCID

5832045

1 reference

13 June 2018

PubMed ID

25113964

1 reference

13 June 2018