(Q48260013)

10 February 2018

title

Receptor tyrosine kinases positively regulate BACE activity and Amyloid-beta production through enhancing BACE internalization. (English)

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10 February 2018

author name string

Lin Zou

1

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10 February 2018

Zhu Wang

2

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10 February 2018

Li Shen

3

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10 February 2018

Guo Bin Bao

4

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10 February 2018

Tian Wang

5

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10 February 2018

Jiu Hong Kang

6

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10 February 2018

Gang Pei

7

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10 February 2018

publication date

1 May 2007

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10 February 2018

published in

Cell Research

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10 February 2018

volume

17

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10 February 2018

issue

5

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10 February 2018

page(s)

389-401

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10 February 2018

https://scigraph.springernature.com/pub.10.1038/cr.2007.5

exact match

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cites work

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Alzheimer's disease: genes, proteins, and therapy

21 January 2018

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Cleavage of amyloid beta peptide during constitutive processing of its precursor

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

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7 January 2021

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

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Purification and cloning of amyloid precursor protein beta-secretase from human brain

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Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

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Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

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7 January 2021

Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

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7 January 2021

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

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7 January 2021

Human β-Secretase (BACE) and BACE Inhibitors

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7 January 2021

Maturation and pro-peptide cleavage of beta-secretase

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7 January 2021

Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer's disease beta-secretase

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7 January 2021

A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase

1 reference

7 January 2021

Processing of beta-secretase by furin and other members of the proprotein convertase family

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7 January 2021

BACE is degraded via the lysosomal pathway

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7 January 2021

Phosphorylation regulates intracellular trafficking of beta-secretase

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7 January 2021

Endosome function and dysfunction in Alzheimer's disease and other neurodegenerative diseases

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7 January 2021

Glucose metabolism and insulin receptor signal transduction in Alzheimer disease

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7 January 2021

c-Src regulates clathrin adapter protein 2 interaction with beta-arrestin and the angiotensin II type 1 receptor during clathrin- mediated internalization

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7 January 2021

Distinct roles for Src tyrosine kinase in beta2-adrenergic receptor signaling to MAPK and in receptor internalization

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7 January 2021

Src-dependent tyrosine phosphorylation regulates dynamin self-assembly and ligand-induced endocytosis of the epidermal growth factor receptor

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7 January 2021

EGF receptor signaling stimulates SRC kinase phosphorylation of clathrin, influencing clathrin redistribution and EGF uptake.

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7 January 2021

NGF signaling from clathrin-coated vesicles: evidence that signaling endosomes serve as a platform for the Ras-MAPK pathway

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Epidermal growth factor and membrane trafficking. EGF receptor activation of endocytosis requires Rab5a

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7 January 2021

Control of EGF receptor signaling by clathrin-mediated endocytosis.

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7 January 2021

Regulation of epidermal growth factor receptor endocytosis by wortmannin through activation of Rab5 rather than inhibition of phosphatidylinositol 3-kinase

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7 January 2021

Regulation of receptor tyrosine kinase signaling by endocytic trafficking

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7 January 2021

Platelet-derived growth factor induces the beta-gamma-secretase-mediated cleavage of Alzheimer's amyloid precursor protein through a Src-Rac-dependent pathway.

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7 January 2021

Beta-arrestin2 is critically involved in CXCR4-mediated chemotaxis, and this is mediated by its enhancement of p38 MAPK activation

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7 January 2021

Androgens modulate beta-amyloid levels in male rat brain.

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7 January 2021

BACE1- and BACE2-expressing human cells: characterization of beta-amyloid precursor protein-derived catabolites, design of a novel fluorimetric assay, and identification of new in vitro inhibitors

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7 January 2021

Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK

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7 January 2021

Borrelia burgdorferi persists in the brain in chronic lyme neuroborreliosis and may be associated with Alzheimer disease

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7 January 2021

Positive and negative regulation of APP amyloidogenesis by sumoylation.

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7 January 2021

Phorbol 12-myristate 13-acetate induces epidermal growth factor receptor transactivation via protein kinase Cdelta/c-Src pathways in glioblastoma cells

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7 January 2021

Neuropeptide-induced transactivation of a neuronal epidermal growth factor receptor is mediated by metalloprotease-dependent formation of heparin-binding epidermal growth factor

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7 January 2021

Dependence of gonadotropin-releasing hormone-induced neuronal MAPK signaling on epidermal growth factor receptor transactivation

1 reference

7 January 2021

SARA, a FYVE domain protein, affects Rab5-mediated endocytosis.

1 reference

7 January 2021

Transgenic BACE expression in mouse neurons accelerates amyloid plaque pathology

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7 January 2021

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

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7 January 2021

Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

1 reference

7 January 2021

Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase

1 reference

7 January 2021

Demonstration of BACE (beta-secretase) phosphorylation and its interaction with GGA1 in cells by fluorescence-lifetime imaging microscopy

1 reference

7 January 2021

Insights into the phosphoregulation of beta-secretase sorting signal by the VHS domain of GGA1.

1 reference

7 January 2021

Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme

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7 January 2021

GGA proteins mediate the recycling pathway of memapsin 2 (BACE).

1 reference

7 January 2021

Nerve growth factor modulates the expression and secretion of beta-amyloid precursor protein through different mechanisms in PC12 cells

1 reference

7 January 2021

Nerve growth factor potentiates the neurotoxicity of beta amyloid

1 reference

7 January 2021

The precursor pro-nerve growth factor is the predominant form of nerve growth factor in brain and is increased in Alzheimer's disease

1 reference

7 January 2021

Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion.

1 reference

7 January 2021

Internalization of exogenously added memapsin 2 (beta-secretase) ectodomain by cells is mediated by amyloid precursor protein

1 reference

7 January 2021

Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes

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7 January 2021

Human BACE forms dimers and colocalizes with APP.

1 reference

7 January 2021

Rab5-stimulated up-regulation of the endocytic pathway increases intracellular beta-cleaved amyloid precursor protein carboxyl-terminal fragment levels and Abeta production

1 reference

7 January 2021

Crosstalk between steroid receptors and the c-Src-receptor tyrosine kinase pathways: implications for cell proliferation

1 reference

7 January 2021

The carboxyl-terminus of BACE contains a sorting signal that regulates BACE trafficking but not the formation of total A(beta).

1 reference

7 January 2021

beta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis

1 reference

7 January 2021

Epidemiology of neurodegeneration

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7 January 2021

Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice

1 reference

7 January 2021

Environmental enrichment mitigates cognitive deficits in a mouse model of Alzheimer's disease

1 reference

7 January 2021

Activation of beta2-adrenergic receptor stimulates gamma-secretase activity and accelerates amyloid plaque formation.

1 reference

7 January 2021

Identifiers

DOI

10.1038/CR.2007.5

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10 February 2018

release_2ebzcmxtsbh7bmaozasmu3k6z4

Fatcat ID

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PubMed ID

17325690

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10 February 2018