(Q48278066)

10 February 2018

title

A New Way Forward in Cancer Drug Discovery: Inhibiting the SWI/SNF Chromatin Remodelling Complex. (English)

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10 February 2018

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1

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10 February 2018

publication date

18 December 2015

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10 February 2018

published in

ChemBioChem

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10 February 2018

volume

17

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10 February 2018

page(s)

677-682

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10 February 2018

issue

8

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10 February 2018

Structure and organization of chromatin fiber in the nucleus

cites work

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https://api.crossref.org/works/10.1002%2FCBIC.201500565

Regulation of chromatin by histone modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500565

SWI/SNF unwraps, slides, and rewraps the nucleosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500565

ATP-dependent chromatin remodeling: genetics, genomics and mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500565

An essential switch in subunit composition of a chromatin remodeling complex during neural development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500565

SWI/SNF chromatin remodeling and human malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500565

The murine SNF5/INI1 chromatin remodeling factor is essential for embryonic development and tumor suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500565

Molecular pathways: SWI/SNF (BAF) complexes are frequently mutated in cancer--mechanisms and potential therapeutic insights.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500565

Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500565

ARID1B is a specific vulnerability in ARID1A-mutant cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500565

Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500565

Essential role of BRG, the ATPase subunit of BAF chromatin remodeling complexes, in leukemia maintenance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500565

The SWI/SNF ATPases Are Required for Triple Negative Breast Cancer Cell Proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500565

MAX inactivation in small cell lung cancer disrupts MYC-SWI/SNF programs and is synthetic lethal with BRG1

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201500565

CARM1 methylates chromatin remodeling factor BAF155 to enhance tumor progression and metastasis

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201500565

Targeting bromodomains: epigenetic readers of lysine acetylation

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201500565

Reversible disruption of mSWI/SNF (BAF) complexes by the SS18-SSX oncogenic fusion in synovial sarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500565

The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500565

LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500565

LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500565

Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201500565

Mechanisms and functions of ATP-dependent chromatin-remodeling enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500565

Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500565

SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201500565

Vulnerabilities of mutant SWI/SNF complexes in cancer.

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201500565

Targeted disruption of the BCL9/β-catenin complex inhibits oncogenic Wnt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500565

Rational design of small-molecule inhibitors for β-catenin/T-cell factor protein-protein interactions by bioisostere replacement

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201500565

Small molecule therapeutics targeting F-box proteins in cancer

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201500565

Mammalian SWI/SNF--a subunit BAF250/ARID1 is an E3 ubiquitin ligase that targets histone H2B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500565

Targeting protein-protein interactions (PPIs) of transcription factors: Challenges of intrinsically disordered proteins (IDPs) and regions (IDRs).

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500565

BAF60 A, B, and Cs of muscle determination and renewal

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500565

Small-molecule inhibitors of the MDM2-p53 protein-protein interaction (MDM2 Inhibitors) in clinical trials for cancer treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500565

Akirin2 is critical for inducing inflammatory genes by bridging IκB-ζ and the SWI/SNF complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500565

FBI1/Akirin2 promotes tumorigenicity and metastasis of Lewis lung carcinoma cells

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201500565

Mutant p53 in cancer: new functions and therapeutic opportunities

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500565

Mutant p53 cooperates with the SWI/SNF chromatin remodeling complex to regulate VEGFR2 in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500565

BAF60a interacts with p53 to recruit the SWI/SNF complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500565

Inhibition of Myc family proteins eradicates KRas-driven lung cancer in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500565

Finding cancer's weakest link

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500565

The action mechanism of the Myc inhibitor termed Omomyc may give clues on how to target Myc for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500565

Modelling Myc inhibition as a cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500565

c-MYC interacts with INI1/hSNF5 and requires the SWI/SNF complex for transactivation function

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FCBIC.201500565

Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway.

21 January 2018

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https://api.crossref.org/works/10.1002%2FCBIC.201500565

21 January 2018

Identifiers

DOI

10.1002/CBIC.201500565

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10 February 2018

PubMed ID

26684344

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10 February 2018