(Q27700161)

9

0 references

Tony Kouzarides

19

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Anne-Marie Michon

15

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Paola Grandi

12

0 references

David Drewry

10

David H Drewry

0 references

Antje Dittmann

Antje Dittmann

8

0 references

Isabelle Becher

Isabelle Becher

4

0 references

Andrew Bannister

Andrew J Bannister

3

0 references

Rab K Prinjha

20

Rab K Prinjha

0 references

Ka Hing Che

6

Ka Hing Che

0 references

author name string

Natalie H Theodoulou

1

0 references

Rino A Bit

5

0 references

Chun-wa Chung

7

0 references

Laurie Gordon

11

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Melanie Leveridge

13

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Matthew Lindon

14

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Judit Molnar

16

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Samuel C Robson

17

0 references

Nicholas C O Tomkinson

18

0 references

Philip G Humphreys

Journal of Medicinal Chemistry

21

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language of work or name

English

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publication date

25 February 2016

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published in

0 references

volume

59

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issue

4

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page(s)

1425-39

0 references

cites work

Fragment-based discovery of bromodomain inhibitors part 1: inhibitor binding modes and implications for lead discovery

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12 December 2020

Phenotypic screening and fragment-based approaches to the discovery of small-molecule bromodomain ligands.

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12 December 2020

The role of human bromodomains in chromatin biology and gene transcription

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12 December 2020

Structure-Guided Design of Potent Diazobenzene Inhibitors for the BET Bromodomains

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12 December 2020

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

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Fragment-based discovery of bromodomain inhibitors part 2: optimization of phenylisoxazole sulfonamides

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Interaction of propionylated and butyrylated histone H3 lysine marks with Brd4 bromodomains

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Discovery and characterization of small molecule inhibitors of the BET family bromodomains

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Place your BETs: the therapeutic potential of bromodomains

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BET bromodomain inhibitors: a patent review

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SAMSN1 is highly expressed and associated with a poor survival in glioblastoma multiforme

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Epigenetic protein families: a new frontier for drug discovery

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12 December 2020

The discovery of I-BET726 (GSK1324726A), a potent tetrahydroquinoline ApoA1 up-regulator and selective BET bromodomain inhibitor

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12 December 2020

Targeting Low-Druggability Bromodomains: Fragment Based Screening and Inhibitor Design against the BAZ2B Bromodomain

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12 December 2020

Chemical biology. A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes

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12 December 2020

Operating on chromatin, a colorful language where context matters

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12 December 2020

Discovery of epigenetic regulator I-BET762: lead optimization to afford a clinical candidate inhibitor of the BET bromodomains

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Optimization of 3,5-Dimethylisoxazole Derivatives as Potent Bromodomain Ligands

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Biased multicomponent reactions to develop novel bromodomain inhibitors.

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Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains

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DUSP6 regulates drug sensitivity by modulating DNA damage response

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12 December 2020

Progress in the development and application of small molecule inhibitors of bromodomain-acetyl-lysine interactions

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12 December 2020

3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands

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12 December 2020

Integrative genomics analysis of chromosome 5p gain in cervical cancer reveals target over-expressed genes, including Drosha

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12 December 2020

[1,2,4]triazolo[4,3-a]phthalazines: inhibitors of diverse bromodomains

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12 December 2020

Discovery, biological evaluation, and structure-activity relationship of amidine based sphingosine kinase inhibitors

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12 December 2020

1,3-Dimethyl Benzimidazolones Are Potent, Selective Inhibitors of the BRPF1 Bromodomain

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12 December 2020

Identification of a novel series of BET family bromodomain inhibitors: binding mode and profile of I-BET151 (GSK1210151A)

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12 December 2020

The bromodomain interaction module

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12 December 2020

Solution structure of BRD7 bromodomain and its interaction with acetylated peptides from histone H3 and H4

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12 December 2020

SS18 together with animal-specific factors defines human BAF-type SWI/SNF complexes

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12 December 2020

Selective inhibition of BET bromodomains

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12 December 2020

Suppression of inflammation by a synthetic histone mimic

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12 December 2020

Small-molecule modulators for epigenetics targets

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12 December 2020

Identification of 2-(4-pyridyl)thienopyridinones as GSK-3β inhibitors

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12 December 2020

A rationale to target the SWI/SNF complex for cancer therapy

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12 December 2020

Epigenetic chemical probes.

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12 December 2020

Target validation using chemical probes

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12 December 2020

RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain

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12 December 2020

Structure and acetyl-lysine recognition of the bromodomain

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12 December 2020

Selective small molecules blocking HIV-1 Tat and coactivator PCAF association

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12 December 2020

Small molecule inhibitors of bromodomain-acetyl-lysine interactions

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12 December 2020

RVX-208, an inducer of ApoA-I in humans, is a BET bromodomain antagonist

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12 December 2020

Fes tyrosine kinase expression in the tumor niche correlates with enhanced tumor growth, angiogenesis, circulating tumor cells, metastasis, and infiltrating macrophages

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12 December 2020

Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy.

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12 December 2020

Histone recognition and large-scale structural analysis of the human bromodomain family

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12 December 2020

Small molecule bromodomain inhibitors: extending the druggable genome

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12 December 2020

Getting physical in drug discovery II: the impact of chromatographic hydrophobicity measurements and aromaticity

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12 December 2020

Identification of a Chemical Probe for Bromo and Extra C-Terminal Bromodomain Inhibition through Optimization of a Fragment-Derived Hit

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12 December 2020

From ApoA1 upregulation to BET family bromodomain inhibition: discovery of I-BET151.

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12 December 2020

A Small Molecule Binding to the Coactivator CREB-Binding Protein Blocks Apoptosis in Cardiomyocytes

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12 December 2020

The human C-type lectin-like receptor CLEC-1 is upregulated by TGF-β and primarily localized in the endoplasmic membrane compartment.

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12 December 2020

Fragment-based screening of the bromodomain of ATAD2.

1 reference

12 December 2020

A series of potent CREBBP bromodomain ligands reveals an induced-fit pocket stabilized by a cation-π interaction

1 reference

12 December 2020

Cooperative binding of two acetylation marks on a histone tail by a single bromodomain

1 reference

12 December 2020

10.1021/ACS.JMEDCHEM.5B00256

Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

25856009

1 reference

Consolidated OpenCitations Corpus – April 2017