(Q48297058)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27669419%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

title

Thermal profiling reveals phenylalanine hydroxylase as an off-target of panobinostat (English)

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24 March 2020

1

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24 March 2020

Esther A Zaal

4

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24 March 2020

Marcus Bantscheff

12

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24 March 2020

author name string

Thilo Werner

2

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24 March 2020

Carola Doce

3

1 reference

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24 March 2020

Ina Tögel

5

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24 March 2020

Crystal A Khan

6

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24 March 2020

Anne Rueger

7

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24 March 2020

Marcel Muelbaier

8

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24 March 2020

Elsa Salzer

9

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24 March 2020

Celia R Berkers

10

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24 March 2020

Paul F Fitzpatrick

11

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24 March 2020

Mikhail M Savitski

13

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24 March 2020

publication date

26 September 2016

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24 March 2020

published in

Nature Chemical Biology

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24 March 2020

volume

12

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24 March 2020

issue

11

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24 March 2020

page(s)

908-910

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Determining target engagement in living systems

24 March 2020

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2185

Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2185

The Cellular Thermal Shift Assay: A Novel Biophysical Assay for In Situ Drug Target Engagement and Mechanistic Biomarker Studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2185

Tracking cancer drugs in living cells by thermal profiling of the proteome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2185

Proteome-wide drug and metabolite interaction mapping by thermal-stability profiling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2185

Chemoproteomic approaches to drug target identification and drug profiling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2185

Target identification and mechanism of action in chemical biology and drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2185

Target identification for small bioactive molecules: finding the needle in the haystack

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2185

Development of the pan-DAC inhibitor panobinostat (LBH589): successes and challenges

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2185

Panobinostat in patients with relapsed/refractory Hodgkin's lymphoma after autologous stem-cell transplantation: results of a phase II study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2185

High-resolution enabled TMT 8-plexing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2185

Thermal proteome profiling for unbiased identification of direct and indirect drug targets using multiplexed quantitative mass spectrometry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2185

Target engagement and drug residence time can be observed in living cells with BRET.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2185

Assembling the glycopeptide antibiotic scaffold: The biosynthesis of A47934 from Streptomyces toyocaensis NRRL15009

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2185

Thermal proteome profiling monitors ligand interactions with cellular membrane proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2185

Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2185

Biosynthesis of thyroid hormone: Basic and clinical aspects

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2185

A human protein atlas for normal and cancer tissues based on antibody proteomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2185

Integrated genomic and functional analyses reveal glyoxalase I as a novel metabolic oncogene in human gastric cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2185

Infants with Tyrosinemia Type 1: Should phenylalanine be supplemented?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2185

Affinity profiling of the cellular kinome for the nucleotide cofactors ATP, ADP, and GTP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2185

Targeted data acquisition for improved reproducibility and robustness of proteomic mass spectrometry assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2185

Measuring and managing ratio compression for accurate iTRAQ/TMT quantification

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2185

Activation of phenylalanine hydroxylase by phenylalanine does not require binding in the active site

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2185

The Amino Acid Specificity for Activation of Phenylalanine Hydroxylase Matches the Specificity for Stabilization of Regulatory Domain Dimers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCHEMBIO.2185

Site-directed mutants of charged residues in the active site of tyrosine hydroxylase

21 January 2018

1 reference

12 December 2020

Panobinostat for the treatment of multiple myeloma: the evidence to date

1 reference

12 December 2020

Phenylalanine levels of 6-10 mg/dl may not be as benign as once thought.

1 reference

12 December 2020

Mapping protein complexes using covalently linked antibodies and isobaric mass tags

1 reference

12 December 2020

Identifiers

DOI

10.1038/NCHEMBIO.2185

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27669419%20AND%20SRC:MED&resulttype=core&format=json

24 March 2020

1 reference