(Q48307712)

10 February 2018

title

Polar bears, antibiotics, and the evolving ribosome (Nobel Lecture). (English)

1 reference

10 February 2018

1 reference

1

Ada Yonath

1 reference

PubMed ID

20535730

retrieved

10 February 2018

language of work or name

English

0 references

publication date

1 June 2010

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10 February 2018

Angewandte Chemie International Edition

published in

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volume

49

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10 February 2018

issue

26

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10 February 2018

page(s)

4341-4354

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10 February 2018

A tunnel in the large ribosomal subunit revealed by three-dimensional image reconstruction

cites work

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Instruction of translating ribosome by nascent peptide

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

The kinetics of ribosomal peptidyl transfer revisited

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Participation of the tRNA A76 hydroxyl groups throughout translation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Induced-fit tightens pleuromutilins binding to ribosomes and remote interactions enable their selectivity

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

The interaction between C75 of tRNA and the A loop of the ribosome stimulates peptidyl transferase activity

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Essential mechanisms in the catalysis of peptide bond formation on the ribosome.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Structural basis for cross-resistance to ribosomal PTC antibiotics

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

X-ray crystallography study on ribosome recycling: the mechanism of binding and action of RRF on the 50S ribosomal subunit

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Structure of functionally activated small ribosomal subunit at 3.3 angstroms resolution

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

The origin of the genetic code

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

23S rRNA 2058A-->G alteration mediates ketolide resistance in combination with deletion in L22.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

A model of protein synthesis based on cryo-electron microscopy of the E. coli ribosome

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

The suitability of multi-metal clusters for phasing in crystallography of large macromolecular assemblies

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Ribosome's mode of function: myths, facts and recent results

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Ribosomal antibiotics: structural basis for resistance, synergism and selectivity

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Antimicrobial agents targeting the ribosome: the issue of selectivity and toxicity - lessons to be learned

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

The side-by-side model of two tRNA molecules allowing the α-helical conformation of the nascent polypeptide during the ribosomal transpeptidation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

An induced-fit mechanism to promote peptide bond formation and exclude hydrolysis of peptidyl-tRNA.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Peptide bond formation does not involve acid-base catalysis by ribosomal residues

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

A crevice adjoining the ribosome tunnel: hints for cotranslational folding

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

The Geometry of the Ribosomal Polypeptide Exit Tunnel

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Biological implications of the ribosome's stunning stereochemistry

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Structural basis for translation termination on the 70S ribosome

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Location of exit channel for nascent protein in 80S ribosome

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

How ribosomes make peptide bonds

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Comprehensive genetic selection revealed essential bases in the peptidyl-transferase center

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Signal sequence recognition and protein targeting to the endoplasmic reticulum membrane

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Crystal structure of an initiation factor bound to the 30S ribosomal subunit

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Parameters for crystal growth of ribosomal subunits

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Side-chain recognition and gating in the ribosome exit tunnel.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

The transition state for formation of the peptide bond in the ribosome

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Structure of trigger factor binding domain in biologically homologous complex with eubacterial ribosome reveals its chaperone action

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Crystal structure of a 70S ribosome-tRNA complex reveals functional interactions and rearrangements

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Structural insight into the role of the ribosomal tunnel in cellular regulation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Structures of the bacterial ribosome at 3.5 A resolution

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Mutation from guanine to adenine in 25S rRNA at the position equivalent to E. coli A2058 does not confer erythromycin sensitivity in Sacchromyces cerevisae

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Toward ribosomal RNA catalytic activity in the absence of protein

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

The ribosome as a drug target

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Peptidyl-CCA deacylation on the ribosome promoted by induced fit and the O3'-hydroxyl group of A76 of the unacylated A-site tRNA

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

The binding mode of the trigger factor on the ribosome: implications for protein folding and SRP interaction.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

The 70S Escherichia coli ribosome at 23 A resolution: fitting the ribosomal RNA.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

The signal sequence moves through a ribosomal tunnel into a noncytoplasmic aqueous environment at the ER membrane early in translocation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Real-time observation of trigger factor function on translating ribosomes.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Partial resistance of nascent polypeptide chains to proteolytic digestion due to ribosomal shielding

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Ribosomal Crystallography: Initiation, Peptide Bond Formation, and Amino Acid Polymerization are Hampered by Antibiotics

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Substrate-assisted catalysis of peptide bond formation by the ribosome

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Ribosomal crystallography: from poorly diffracting microcrystals to high-resolution structures

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

The complete atomic structure of the large ribosomal subunit at 2.4 A resolution

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Rapid ribosomal translocation depends on the conserved 18-55 base pair in P-site transfer RNA.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Controlled proteolysis of nascent polypeptides in rat liver cell fractions. II. Location of the polypeptides in rough microsomes

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Ribosome exit tunnel can entropically stabilize alpha-helices

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Mechanism of ribosomal peptide bond formation.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

The ribosomal peptidyl transferase

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Antibiotic blocks mRNA path on the ribosome.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Involvement of RNA in the synthesis of proteins

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Analysis of predictions for the catalytic mechanism of ribosomal peptidyl transfer

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

The linkage between ribosomal crystallography, metal ions, heteropolytungstates and functional flexibility

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Peptide bond formation destabilizes Shine-Dalgarno interaction on the ribosome

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Analysis of mutations at residues A2451 and G2447 of 23S rRNA in the peptidyltransferase active site of the 50S ribosomal subunit

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

What are the roles of substrate-assisted catalysis and proximity effects in peptide bond formation by the ribosome?

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Structure of the 70S ribosome complexed with mRNA and tRNA

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

The bacterial ribosome as a target for antibiotics

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Generation of ribosome nascent chain complexes for structural and functional studies

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Structure of Bacterial Ribosomes

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Nascent membrane and secretory proteins differ in FRET-detected folding far inside the ribosome and in their exposure to ribosomal proteins.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Characterization and preliminary attempts for derivatization of crystals of large ribosomal subunits from Haloarcula marismortui diffracting to 3 A resolution

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Insights into Translational Termination from the Structure of RF2 Bound to the Ribosome

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Antibiotics and the ribosome.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Antibiotics targeting ribosomes: resistance, selectivity, synergism and cellular regulation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Inactivation and reactivation of ribosomal subunits: amino acyl-transfer RNA binding activity of the 30 s subunit of Escherichia coli.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Barreling through the membrane

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Crystal structure of the ribosome at 5.5 A resolution

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

The ribosomal exit tunnel functions as a discriminating gate

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Reproducible growth of well diffracting ribosomal crystals

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Changes produced by bound tryptophan in the ribosome peptidyl transferase center in response to TnaC, a nascent leader peptide

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Elongation arrest by SecM via a cascade of ribosomal RNA rearrangements

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

From peptide-bond formation to cotranslational folding: dynamic, regulatory and evolutionary aspects

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

The structural basis of ribosome activity in peptide bond synthesis

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Rapid peptide bond formation on isolated 50S ribosomal subunits

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Correlating ribosome function with high-resolution structures

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Correlation between the peptidyl transferase activity of the 50 s ribosomal subunit and the ability of the subunit to interact with antibiotics

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Structural basis for messenger RNA movement on the ribosome

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Ribosomal peptidyl transferase can withstand mutations at the putative catalytic nucleotide

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Insights into the decoding mechanism from recent ribosome structures

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Structural basis of the ribosomal machinery for peptide bond formation, translocation, and nascent chain progression

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Histidine 229 in protein L2 is apparently essential for 50S peptidyl transferase activity

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Three-dimensional structures of translating ribosomes by Cryo-EM.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

A hierarchical model for evolution of 23S ribosomal RNA.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Aminoacyl-RNA synthesis catalyzed by an RNA.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

On peptide bond formation, translocation, nascent protein progression and the regulatory properties of ribosomes. Delivered on 20 October 2002 at the 28th FEBS Meeting in Istanbul

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Testing the conservation of the translational machinery over evolution in diverse environments: assaying Thermus thermophilus ribosomes and initiation factors in a coupled transcription-translation system from Escherichia coli

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

The evolving ribosome: from non-coded peptide bond formation to sophisticated translation machinery

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Unusual resistance of peptidyl transferase to protein extraction procedures

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Symmetry at the active site of the ribosome: structural and functional implications

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Some x-ray diffraction patterns from single crystals of the large ribosomal subunit from Bacillus stearothermophilus

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

23S rRNA base pair 2057-2611 determines ketolide susceptibility and fitness cost of the macrolide resistance mutation 2058A-->G.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Modeling a minimal ribosome based on comparative sequence analysis

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Self-sustained replication of an RNA enzyme

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Characterization of crystals of small ribosomal subunits

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Crystal structures of complexes of the small ribosomal subunit with tetracycline, edeine and IF3.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Cotranslational protein folding--fact or fiction?

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Structural insights into the roles of water and the 2' hydroxyl of the P site tRNA in the peptidyl transferase reaction

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Mitochondrial deafness alleles confer misreading of the genetic code

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

The polypeptide tunnel system in the ribosome and its gating in erythromycin resistance mutants of L4 and L22.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Cryocrystallography of ribosomal particles

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Translation arrest requires two-way communication between a nascent polypeptide and the ribosome.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Does the channel for nascent peptide exist inside the ribosome? Immune electron microscopy study

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Insights into substrate stabilization from snapshots of the peptidyl transferase center of the intact 70S ribosome

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Structural basis for aminoglycoside inhibition of bacterial ribosome recycling

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

A small particulate component of the cytoplasm

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Ribosomal tolerance and peptide bond formation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

The ribosomal peptidyl transferase center: structure, function, evolution, inhibition

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Alterations at the peptidyl transferase centre of the ribosome induced by the synergistic action of the streptogramins dalfopristin and quinupristin

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Efficiency of a self-aminoacylating ribozyme: effect of the length and base-composition of its 3' extension

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

High resolution structure of the large ribosomal subunit from a mesophilic eubacterium

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1002/ANIE.201001297

Identifiers

DOI

10.1002/ANIE.201001297

1 reference

10 February 2018

PubMed ID

20535730

1 reference

10 February 2018