(Q48371807)

11 February 2018

title

The regulatory mechanism of the caspase 6 pro-domain revealed by crystal structure and biochemical assays (English)

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11 February 2018

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Qin Cao

1

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11 February 2018

Xiao-Jun Wang

series ordinal

2

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11 February 2018

Lan-Fen Li

series ordinal

3

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11 February 2018

Xiao-Dong Su

series ordinal

4

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11 February 2018

publication date

24 December 2013

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11 February 2018

Acta Crystallographica Section D: Biological Crystallography

published in

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11 February 2018

volume

70

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11 February 2018

issue

Pt 1

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11 February 2018

page(s)

58-67

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11 February 2018

PHENIX: a comprehensive Python-based system for macromolecular structure solution

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Inhibitory Mechanism of Caspase-6 Phosphorylation Revealed by Crystal Structures, Molecular Dynamics Simulations, and Biochemical Assays

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Mechanistic and Structural Understanding of Uncompetitive Inhibitors of Caspase-6

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Extent of N-terminal methionine excision from Escherichia coli proteins is governed by the side-chain length of the penultimate amino acid

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The structure of procaspase 6 is similar to that of active mature caspase 6.

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Self-activation of Caspase-6 in vitro and in vivo: Caspase-6 activation does not induce cell death in HEK293T cells.

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Caspase-6 does not contribute to the proteolysis of mutant huntingtin in the HdhQ150 knock-in mouse model of Huntington's disease

21 January 2018

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21 January 2018

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A new apo-caspase-6 crystal form reveals the active conformation of the apoenzyme.

21 January 2018

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APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

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21 January 2018

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21 January 2018

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Substrate-Induced Conformational Changes Occur in All Cleaved Forms of Caspase-6

21 January 2018

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Phosphorylation regulates assembly of the caspase-6 substrate-binding groove

21 January 2018

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Crystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self-activation

21 January 2018

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Mechanisms of apoptosis through structural biology

21 January 2018

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10.1107/S1399004713024218

21 January 2018

Identifiers

DOI

1 reference

11 February 2018

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11 February 2018