(Q48497433)

12 February 2018

title

Neuroprotective Effect of TREM-2 in Aging and Alzheimer's Disease Model. (English)

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12 February 2018

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7

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12 February 2018

author name string

Animesh Alexander Raha

1

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12 February 2018

James W Henderson

2

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12 February 2018

Simon R W Stott

3

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12 February 2018

Romina Vuono

4

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12 February 2018

Simona Foscarin

5

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12 February 2018

Robert P Friedland

6

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12 February 2018

Ruma Raha-Chowdhury

8

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12 February 2018

publication date

20 September 2016

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12 February 2018

Journal of Alzheimer's Disease

published in

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12 February 2018

volume

55

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12 February 2018

issue

1

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12 February 2018

page(s)

199-217

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12 February 2018

Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau.

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The systemic iron-regulatory proteins hepcidin and ferroportin are reduced in the brain in Alzheimer's disease

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Cloning and characterization of a novel mouse myeloid DAP12-associated receptor family

21 January 2018

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Specific lipid recognition is a general feature of CD300 and TREM molecules.

21 January 2018

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TREM2 and Risk of Alzheimer's Disease--Friend or Foe?

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R47H TREM2 variant increases risk of typical early-onset Alzheimer's disease but not of prion or frontotemporal dementia

21 January 2018

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A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia

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TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis

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TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice

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Dap12 and Trem2, molecules involved in innate immunity and neurodegeneration, are co-expressed in the CNS.

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TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function

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A survey of TREM2 antibodies reveals neuronal but not microglial staining in formalin-fixed paraffin-embedded postmortem Alzheimer's brain tissues

21 January 2018

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TREM2 sustains microglial expansion during aging and response to demyelination

21 January 2018

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Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype

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Developmental regulation of TREM2 and DAP12 expression in the murine CNS: implications for Nasu-Hakola disease

21 January 2018

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Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

21 January 2018

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Learning and memory in transgenic mice modeling Alzheimer's disease

21 January 2018

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Dense-core plaques in Tg2576 and PSAPP mouse models of Alzheimer's disease are centered on vessel walls

21 January 2018

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Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2.

21 January 2018

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TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models.

21 January 2018

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TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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TREM2 governs Kupffer cell activation and explains belr1 genetic resistance to malaria liver stage infection

21 January 2018

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TREM2 and β-catenin regulate bone homeostasis by controlling the rate of osteoclastogenesis

21 January 2018

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Immune attack: the role of inflammation in Alzheimer disease.

21 January 2018

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The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease

21 January 2018

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UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis

21 January 2018

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Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosis

21 January 2018

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21 January 2018

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21 January 2018

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Macrophages in Alzheimer's disease: the blood-borne identity

21 January 2018

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21 January 2018

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21 January 2018

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TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

21 January 2018

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Distribution and signaling of TREM2/DAP12, the receptor system mutated in human polycystic lipomembraneous osteodysplasia with sclerosing leukoencephalopathy dementia

21 January 2018

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Triggering receptor expressed in myeloid cells 2 (TREM2) trafficking in microglial cells: continuous shuttling to and from the plasma membrane regulated by cell stimulation.

21 January 2018

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21 January 2018

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Interleukin 1 receptor 1 and interleukin 1β regulate megakaryocyte maturation, platelet activation, and transcript profile during inflammation in mice and humans

21 January 2018

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Onset and progression in inherited ALS determined by motor neurons and microglia

21 January 2018

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Innate immunity: the missing link in neuroprotection and neurodegeneration?

21 January 2018

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Controlled autoimmunity in CNS maintenance and repair: naturally occurring CD4+CD25+ regulatory T-Cells at the crossroads of health and disease

21 January 2018

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Il10 deficiency rebalances innate immunity to mitigate Alzheimer-like pathology

21 January 2018

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https://api.crossref.org/works/10.3233%2FJAD-160663

Innate Immunity Fights Alzheimer's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-160663

21 January 2018

Identifiers

DOI

10.3233/JAD-160663

0 references

1 reference

12 February 2018