(Q48546721)

12 February 2018

title

Single amino acid substitutions alter the efficiency of docking in modular polyketide biosynthesis (English)

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12 February 2018

author name string

Kira J Weissman

series ordinal

1

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12 February 2018

publication date

1 September 2006

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12 February 2018

published in

ChemBioChem

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12 February 2018

volume

7

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12 February 2018

issue

9

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12 February 2018

page(s)

1334-1342

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12 February 2018

4-[2-(2-amino-2-oxoethyl)-2,7-dihydroxy-4-oxochroman-5-yl]-3-hydroxybut-2-enoic acid

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An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea

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Modular organization of genes required for complex polyketide biosynthesis

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Production of hybrid 16-membered macrolides by expressing combinations of polyketide synthase genes in engineered Streptomyces fradiae hosts

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An unexpected interaction between the modular polyketide synthases, erythromycin DEBS1 and pikromycin PikAIV, leads to efficient triketide lactone synthesis

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Precursor-directed biosynthesis of 16-membered macrolides by the erythromycin polyketide synthase.

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Broad substrate specificity of ketoreductases derived from modular polyketide synthases.

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Quantitative analysis of the relative contributions of donor acyl carrier proteins, acceptor ketosynthases, and linker regions to intermodular transfer of intermediates in hybrid polyketide synthases

21 January 2018

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The structure of docking domains in modular polyketide synthases

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High-resolution structure of the HNF-1alpha dimerization domain

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The structural basis for docking in modular polyketide biosynthesis

21 January 2018

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Selective protein-protein interactions direct channeling of intermediates between polyketide synthase modules

21 January 2018

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Knowledge-based design of bimodular and trimodular polyketide synthases based on domain and module swaps: a route to simple statin analogues

21 January 2018

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NRPS-PKS: a knowledge-based resource for analysis of NRPS/PKS megasynthases

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Genetic manipulation of antibiotic-producing Streptomyces

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Integration site for Streptomyces phage phiBT1 and development of site-specific integrating vectors

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Intermodular communication in modular polyketide synthases: structural and mutational analysis of linker mediated protein-protein recognition

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Catalytically active tetramodular 6-deoxyerythonolide B synthase fusion proteins

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Protein-protein interactions: structurally conserved residues distinguish between binding sites and exposed protein surfaces

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Structural characterisation and functional significance of transient protein-protein interactions

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Intergeneric conjugation between Escherichia coli and Streptomyces species

21 January 2018

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Construction of new vectors for high-level expression in actinomycetes

21 January 2018

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A new modular polyketide synthase in the erythromycin producer Saccharopolyspora erythraea.

21 January 2018

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A Novel Erythromycin, 6-Desmethyl Erythromycin D, Made by Substituting an Acyltransferase Domain of the Erythromycin Polyketide Synthase

21 January 2018

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COCI

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.56.543

12 April 2024

Identifiers

DOI

10.1002/CBIC.200600185

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12 February 2018

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12 February 2018