(Q48610619)

http://europepmc.org/abstract/PMC/5851116

14 June 2018

title

Glycolysis gatekeeper PDK1 reprograms breast cancer stem cells under hypoxia. (English)

1 reference

http://europepmc.org/abstract/PMC/5851116

14 June 2018

main subject

neoplastic stem cells

1 reference

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29106390%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

author name string

F Peng

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29106390%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

J-H Wang

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29106390%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

W-J Fan

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29106390%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Y-T Meng

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29106390%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

M-M Li

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29106390%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

T-T Li

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29106390%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

B Cui

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29106390%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

H-F Wang

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29106390%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Y Zhao

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29106390%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

F An

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29106390%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

T Guo

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29106390%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

X-F Liu

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29106390%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

L Zhang

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29106390%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

L Lv

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29106390%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

D-K Lv

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29106390%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

L-Z Xu

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29106390%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

J-J Xie

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29106390%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

W-X Lin

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29106390%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

J Xu

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29106390%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Q Liu

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29106390%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

language of work or name

English

0 references

publication date

6 November 2017

1 reference

http://europepmc.org/abstract/PMC/5851116

14 June 2018

published in

Oncogene

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29106390%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

volume

37

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29106390%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

issue

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29106390%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

page(s)

1062-1074

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29106390%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/onc.2017.368

7 June 2020

exact match

0 references

cites work

Hypoxia promotes mitochondrial glutamine metabolism through HIF1α-GDH pathway in human lung cancer cells

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Cancer stem cell metabolism: a potential target for cancer therapy

14 June 2018

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Mitochondrial Akt Regulation of Hypoxic Tumor Reprogramming

14 June 2018

1 reference

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Long noncoding RNA CPS1-IT1 suppresses the metastasis of hepatocellular carcinoma by regulating HIF-1α activity and inhibiting epithelial-mesenchymal transition.

14 June 2018

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14 June 2018

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Repurposing atovaquone: targeting mitochondrial complex III and OXPHOS to eradicate cancer stem cells

14 June 2018

1 reference

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Aspirin Suppresses the Acquisition of Chemoresistance in Breast Cancer by Disrupting an NFκB-IL6 Signaling Axis Responsible for the Generation of Cancer Stem Cells

14 June 2018

1 reference

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14 June 2018

1 reference

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The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer

14 June 2018

1 reference

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NANOG Metabolically Reprograms Tumor-Initiating Stem-like Cells through Tumorigenic Changes in Oxidative Phosphorylation and Fatty Acid Metabolism.

14 June 2018

1 reference

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Long Noncoding RNA Ceruloplasmin Promotes Cancer Growth by Altering Glycolysis

14 June 2018

1 reference

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Targeting PDK1 with dichloroacetophenone to inhibit acute myeloid leukemia (AML) cell growth

14 June 2018

1 reference

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5-fluorouracil resistant colon cancer cells are addicted to OXPHOS to survive and enhance stem-like traits

14 June 2018

1 reference

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LncRNA-Hh Strengthen Cancer Stem Cells Generation in Twist-Positive Breast Cancer via Activation of Hedgehog Signaling Pathway

14 June 2018

1 reference

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PDK1-Dependent Metabolic Reprogramming Dictates Metastatic Potential in Breast Cancer

14 June 2018

1 reference

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Hypoxia-regulated lncRNAs in cancer.

14 June 2018

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Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5851116

Aspirin counteracts cancer stem cell features, desmoplasia and gemcitabine resistance in pancreatic cancer

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5851116

The role of non-coding RNAs in the regulation of stem cells and progenitors in the normal mammary gland and in breast tumors

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5851116

PROGgeneV2: enhancements on the existing database

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5851116

Metabolic reprogramming orchestrates cancer stem cell properties in nasopharyngeal carcinoma

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5851116

Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1.

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5851116

The ways of action of long non-coding RNAs in cytoplasm and nucleus

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5851116

Long non-coding RNA UCA1 promotes glycolysis by upregulating hexokinase 2 through the mTOR-STAT3/microRNA143 pathway

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5851116

Targeting lactate dehydrogenase--a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells.

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5851116

Regulation of metabolism by long, non-coding RNAs

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5851116

Targeting unique metabolic properties of breast tumor initiating cells

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5851116

Combined targeting of PDK1 and EGFR triggers regression of glioblastoma by reversing the Warburg effect

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5851116

Metabolic regulation of cancer cell side population by glucose through activation of the Akt pathway.

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5851116

The imprinted H19 lncRNA antagonizes let-7 microRNAs.

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5851116

Energy metabolism characterization of a novel cancer stem cell-like line 3AB-OS.

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5851116

Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5851116

Targeting cellular metabolism to improve cancer therapeutics

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5851116

Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer.

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5851116

BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5851116

Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5851116

Cancer stem cells and epithelial-mesenchymal transition: concepts and molecular links

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5851116

Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming.

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5851116

A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language?

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5851116

Metabolic alterations in highly tumorigenic glioblastoma cells: preference for hypoxia and high dependency on glycolysis

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5851116

Hallmarks of Cancer: The Next Generation

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5851116

SLUG/SNAI2 and tumor necrosis factor generate breast cells with CD44+/CD24- phenotype.

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5851116

Metabolic modulation of glioblastoma with dichloroacetate

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5851116

Induced pluripotent stem cells: current progress and potential for regenerative medicine

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5851116

Efficient tumour formation by single human melanoma cells

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5851116

A search for conserved sequences in coding regions reveals that the let-7 microRNA targets Dicer within its coding sequence

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5851116

Cancer stem cells in solid tumours: accumulating evidence and unresolved questions

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5851116

Module map of stem cell genes guides creation of epithelial cancer stem cells

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5851116

Selective targeting of cancer stem cells: a new concept in cancer therapeutics

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5851116

HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5851116

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5851116

Cancer stem cells: an old idea--a paradigm shift

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5851116

Aspirin inhibits NF-kappaB activation in a glycolysis-depleted lung epithelial cell line

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5851116

Distinct regulatory properties of pyruvate dehydrogenase kinase and phosphatase isoforms

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5851116

General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5851116

The aspirin-induced long non-coding RNA OLA1P2 blocks phosphorylated STAT3 homodimer formation

14 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5851116

MYC/PGC-1α Balance Determines the Metabolic Phenotype and Plasticity of Pancreatic Cancer Stem Cells.

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5851116

DCA promotes progression of neuroblastoma tumors in nude mice

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5851116

Dichloroacetate, a selective mitochondria-targeting drug for oral squamous cell carcinoma: a metabolic perspective of treatment.

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5851116

Tumor hypoxia induces nuclear paraspeckle formation through HIF-2α dependent transcriptional activation of NEAT1 leading to cancer cell survival.

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5851116

Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivo

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5851116

Unexpected Discovery of Dichloroacetate Derived Adenosine Triphosphate Competitors Targeting Pyruvate Dehydrogenase Kinase To Inhibit Cancer Proliferation.

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5851116

Pyruvate dehydrogenase kinase expression and metabolic changes following dichloroacetate exposure in anoxic human colorectal cancer cells.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5851116

Tumor initiating cells and chemoresistance: which is the best strategy to target colon cancer stem cells?

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5851116

HIF1α modulates cell fate reprogramming through early glycolytic shift and upregulation of PDK1-3 and PKM2.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5851116

Endogenous miRNA sponge lincRNA-RoR regulates Oct4, Nanog, and Sox2 in human embryonic stem cell self-renewal

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5851116

ELDA: extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5851116

Reciprocal regulation of HIF-1α and lincRNA-p21 modulates the Warburg effect

14 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FONC.2017.368

Mitochondrial and energy metabolism-related properties as novel indicators of lung cancer stem cells

31 March 2020

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FONC.2017.368

31 March 2020

Identifiers

DOI

10.1038/ONC.2017.368

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29106390%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

7 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29106390%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

PubMed publication ID

29106390

1 reference