(Q48684324)

14 February 2018

title

Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole. (English)

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14 February 2018

author name string

H Huang

1

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14 February 2018

H Wang

2

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14 February 2018

M Sinz

3

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14 February 2018

M Zoeckler

4

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14 February 2018

J Staudinger

5

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14 February 2018

M R Redinbo

6

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14 February 2018

D G Teotico

7

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14 February 2018

J Locker

8

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14 February 2018

G V Kalpana

9

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14 February 2018

S Mani

10

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14 February 2018

language of work or name

English

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publication date

3 July 2006

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14 February 2018

published in

Oncogene

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14 February 2018

volume

26

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14 February 2018

page(s)

258-268

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14 February 2018

issue

2

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14 February 2018

https://scigraph.springernature.com/pub.10.1038/sj.onc.1209788

exact match

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cites work

Automated yeast two-hybrid screening for nuclear receptor-interacting proteins

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Ketoconazole inhibits the biosynthesis of leukotrienes in vitro and in vivo.

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Management of advanced prostate cancer after first-line chemotherapy

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7 January 2021

Ligand-activated pregnane X receptor interferes with HNF-4 signaling by targeting a common coactivator PGC-1alpha. Functional implications in hepatic cholesterol and glucose metabolism.

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SXR, a novel steroid and xenobiotic-sensing nuclear receptor

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The nuclear receptor coactivator PGC-1alpha exhibits modes of interaction with the estrogen receptor distinct from those of SRC-1.

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7 January 2021

Induction of drug metabolism by forskolin: the role of the pregnane X receptor and the protein kinase a signal transduction pathway

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7 January 2021

Pharmacokinetic-pharmacodynamic consequences and clinical relevance of cytochrome P450 3A4 inhibition

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Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance

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7 January 2021

Ketoconazole and 25-hydroxycholesterol produce reciprocal changes in the rate of transcription of the human LDL receptor gene

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Coordinate transcriptional regulation of transport and metabolism

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The nuclear receptor superfamily: a rosetta stone for physiology

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In vitro farnesoid X receptor ligand sensor assay using surface plasmon resonance and based on ligand-induced coactivator association

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7 January 2021

Regulation of CYP3A4 by the bile acid receptor FXR: evidence for functional binding sites in the CYP3A4 gene

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7 January 2021

A case of confluent and reticulated papillomatosis responsive to ketoconazole cream.

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7 January 2021

Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR.

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7 January 2021

Regulation and binding of pregnane X receptor by nuclear receptor corepressor silencing mediator of retinoid and thyroid hormone receptors (SMRT).

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7 January 2021

Ketoconazole suppresses interleukin-4 plus anti-CD40-induced IgE class switching in surface IgE negative B cells from patients with atopic dermatitis

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7 January 2021

Ketoconazole suppresses prostaglandin E(2)-induced cyclooxygenase-2 expression in human epidermoid carcinoma A-431 cells

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7 January 2021

The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism

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7 January 2021

Employment of the human estrogen receptor beta ligand-binding domain and co-activator SRC1 nuclear receptor-binding domain for the construction of a yeast two-hybrid detection system for endocrine disrupters

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7 January 2021

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

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7 January 2021

Mechanism of rifampicin and pregnane X receptor inhibition of human cholesterol 7 alpha-hydroxylase gene transcription.

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7 January 2021

Ketoconazole blocks adrenal steroidogenesis by inhibiting cytochrome P450-dependent enzymes

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7 January 2021

Vitamin D receptor as an intestinal bile acid sensor

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7 January 2021

Activation of the steroid and xenobiotic receptor (human pregnane X receptor) by nontaxane microtubule-stabilizing agents

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7 January 2021

Methionine enhances alcohol-induced narcosis in mice.

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7 January 2021

Dual effect of dexamethasone on CYP3A4 gene expression in human hepatocytes. Sequential role of glucocorticoid receptor and pregnane X receptor.

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7 January 2021

Hormones and resistance

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7 January 2021

Dynamic inhibition of nuclear receptor activation by corepressor binding

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7 January 2021

A nuclear receptor-mediated xenobiotic response and its implication in drug metabolism and host protection.

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7 January 2021

Ketoconazole inhibits corticotropic cell function in vitro

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7 January 2021

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

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7 January 2021

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209788

7 January 2021

Highly chlorinated PCBs inhibit the human xenobiotic response mediated by the steroid and xenobiotic receptor (SXR).

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209788

7 January 2021

Putative role of the orphan nuclear receptor SXR (steroid and xenobiotic receptor) in the mechanism of CYP3A4 inhibition by xenobiotics

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209788

7 January 2021

The preventive effect of ketoconazole on experimental metastasis from a human pancreatic carcinoma may be related to its effect on prostaglandin synthesis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209788

7 January 2021

Pharmacokinetic variability of anticancer agents

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209788

7 January 2021

Effects of the antifungal agents on oxidative drug metabolism: clinical relevance

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209788

7 January 2021

Specific and overlapping functions of the nuclear hormone receptors CAR and PXR in xenobiotic response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209788

7 January 2021

The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209788

7 January 2021

Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209788

7 January 2021

An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209788

7 January 2021

Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209788

7 January 2021

Two cases of confluent and reticulate papillomatosis: successful treatments of one case with cefdinir and another with minocycline

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209788

7 January 2021

Effects of ketoconazole on glucuronidation by UDP-glucuronosyltransferase enzymes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209788

7 January 2021

Correlation of high-throughput pregnane X receptor (PXR) transactivation and binding assays

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209788

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1209788

1 reference

14 February 2018

PubMed ID

16819505

1 reference

14 February 2018