(Q48736362)

15 February 2018

http://europepmc.org/abstract/MED/27179792

title

BIN1 regulates BACE1 intracellular trafficking and amyloid-β production (English)

1 reference

15 February 2018

http://europepmc.org/abstract/MED/27179792

main subject

Bridging integrator 1

1 reference

negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

Bridging integrator 1

1 reference

GOA release 2020-03-11

author

Taisuke Tomita

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27179792%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

author name string

Toji Miyagawa

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27179792%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Ihori Ebinuma

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27179792%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Yuichi Morohashi

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27179792%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Yukiko Hori

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27179792%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Mee Young Chang

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27179792%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Haruhiko Hattori

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27179792%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Tomoaki Maehara

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27179792%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Satoshi Yokoshima

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27179792%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Tohru Fukuyama

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27179792%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Shoji Tsuji

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27179792%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Takeshi Iwatsubo

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27179792%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

George C Prendergast

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27179792%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

publication date

14 May 2016

1 reference

15 February 2018

http://europepmc.org/abstract/MED/27179792

published in

Human Molecular Genetics

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27179792%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

volume

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27179792%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

issue

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27179792%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

page(s)

2948-2958

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27179792%20AND%20SRC:MED&resulttype=core&format=json

Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

6 June 2020

cites work

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

Purification and cloning of amyloid precursor protein beta-secretase from human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

21 January 2018

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https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

The role of APP and BACE1 trafficking in APP processing and amyloid-β generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

Protein trafficking and maturation regulate intramembrane proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

Bridging integrator 1 (BIN1): form, function, and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

Amphiphysin 2 (BIN1) in physiology and diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

Amphiphysin 2 (Bin1) and T-tubule biogenesis in muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

Amphiphysin II (SH3P9; BIN1), a member of the amphiphysin/Rvs family, is concentrated in the cortical cytomatrix of axon initial segments and nodes of ranvier in brain and around T tubules in skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

A role for the putative tumor suppressor Bin1 in muscle cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

AMPH-1/Amphiphysin/Bin1 functions with RME-1/Ehd1 in endocytic recycling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

Targeted disruption of the murine Bin1/Amphiphysin II gene does not disable endocytosis but results in embryonic cardiomyopathy with aberrant myofibril formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

Structural analysis of the human BIN1 gene. Evidence for tissue-specific transcriptional regulation and alternate RNA splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

Mechanism for elimination of a tumor suppressor: aberrant splicing of a brain-specific exon causes loss of function of Bin1 in melanoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

BACE1 activity is modulated by cell-associated sphingosine-1-phosphate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

Cell-surface protein-protein interaction analysis with time-resolved FRET and snap-tag technologies: application to GPCR oligomerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

A general method for the covalent labeling of fusion proteins with small molecules in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

BACE is degraded via the lysosomal pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

Snapin-mediated BACE1 retrograde transport is essential for its degradation in lysosomes and regulation of APP processing in neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

BACE1 protein endocytosis and trafficking are differentially regulated by ubiquitination at lysine 501 and the Di-leucine motif in the carboxyl terminus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

Ubiquitin regulates GGA3-mediated degradation of BACE1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

Mutations in amphiphysin 2 (BIN1) disrupt interaction with dynamin 2 and cause autosomal recessive centronuclear myopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

N-WASP is required for Amphiphysin-2/BIN1-dependent nuclear positioning and triad organization in skeletal muscle and is involved in the pathophysiology of centronuclear myopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

The myotubularin-amphiphysin 2 complex in membrane tubulation and centronuclear myopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

BIN1 membrane curvature sensing and generation show autoinhibition regulated by downstream ligands and PI(4,5)P2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

Cooperative recruitment of dynamin and BIN/amphiphysin/Rvs (BAR) domain-containing proteins leads to GTP-dependent membrane scission

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

The crystal structure of the BAR domain from human Bin1/amphiphysin II and its implications for molecular recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

The BAR-domain family of proteins: a case of bending and binding?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

Bin1 interacts with and restrains the DNA end-binding protein complex Ku.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

Role of genes linked to sporadic Alzheimer's disease risk in the production of β-amyloid peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

Depletion of GGA1 and GGA3 mediates postinjury elevation of BACE1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

A function for EHD family proteins in unidirectional retrograde dendritic transport of BACE1 and Alzheimer's disease Aβ production

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

EHD proteins: key conductors of endocytic transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

EHD1 mediates vesicle trafficking required for normal muscle growth and transverse tubule development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

EHD1 is a synaptic protein that modulates exocytosis through binding to snapin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

Subcellular compartment and molecular subdomain of beta-amyloid precursor protein relevant to the Abeta 42-promoting effects of Alzheimer mutant presenilin 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

Genetic screens in human cells using the CRISPR-Cas9 system

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

Genome engineering using the CRISPR-Cas9 system

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

Discovery of an Orally Available, Brain Penetrant BACE1 Inhibitor That Affords Robust CNS Aβ Reduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

Decreased CALM expression reduces Aβ42 to total Aβ ratio through clathrin-mediated endocytosis of γ-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

Inverse synaptic tagging of inactive synapses via dynamic interaction of Arc/Arg3.1 with CaMKIIβ

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

Genetic analysis of Mint/X11 proteins: essential presynaptic functions of a neuronal adaptor protein family

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

Activity-dependent proteolytic cleavage of neuroligin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

Monitoring autophagy in lysosomal storage disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

C-terminal Fragment of Presenilin Is the Molecular Target of a Dipeptidic γ-Secretase-specific Inhibitor DAPT (N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycinet-Butyl Ester)

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

Primary cultures of neuronal and non-neuronal rat brain cells secrete similar proportions of amyloid β peptides ending at Aβ40 and Aβ42

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDW146

21 January 2018

Identifiers

DOI

10.1093/HMG/DDW146

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27179792%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

1 reference