(Q24338376)

regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process

GO:1902944

2 references

GO:1902959

positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process

GOA release 2020-03-11

1 reference

negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process

GO:1902961

1 reference

Phosphatidylinositol binding clathrin assembly protein

GO:1902960

1 reference

Phosphatidylinositol binding clathrin assembly protein

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Taisuke Tomita

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24577224%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

author name string

Kunihiko Kanatsu

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24577224%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Yuichi Morohashi

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24577224%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Mai Suzuki

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24577224%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Hiromasa Kuroda

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24577224%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Toshio Watanabe

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24577224%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

Takeshi Iwatsubo

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24577224%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

language of work or name

English

0 references

publication date

2014

0 references

published in

Nature Communications

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24577224%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

volume

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24577224%20AND%20SRC:MED&resulttype=core&format=json

7 June 2020

page(s)

3386

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24577224%20AND%20SRC:MED&resulttype=core&format=json

Secretase inhibitors and modulators for Alzheimer's disease treatment

7 June 2020

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

Structural biology of presenilins and signal peptide peptidases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

The role of presenilin cofactors in the gamma-secretase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

Novel research horizons for presenilins and γ-secretases in cell biology and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

Presenilin-1, Nicastrin, Amyloid Precursor Protein, and γ-Secretase Activity Are Co-localized in the Lysosomal Membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

Endosomal entry regulates Notch receptor activation in Drosophila melanogaster

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

The t(10;11)(p13;q14) in the U937 cell line results in the fusion of the AF10 gene and CALM, encoding a new member of the AP-3 clathrin assembly protein family

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

Effect of clathrin assembly lymphoid myeloid leukemia protein depletion on clathrin coat formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

The molecular basis for the endocytosis of small R-SNAREs by the clathrin adaptor CALM

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

Role of phosphatidylinositol clathrin assembly lymphoid-myeloid leukemia (PICALM) in intracellular amyloid precursor protein (APP) processing and amyloid plaque pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

The clathrin assembly protein PICALM is required for erythroid maturation and transferrin internalization in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

Accumulation of murine amyloidbeta42 in a gene-dosage-dependent manner in PS1 'knock-in' mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

Potent amyloidogenicity and pathogenicity of Aβ43.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

APP processing and synaptic plasticity in presenilin-1 conditional knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

Subcellular compartment and molecular subdomain of beta-amyloid precursor protein relevant to the Abeta 42-promoting effects of Alzheimer mutant presenilin 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

Gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

Sorting of the Alzheimer's disease amyloid precursor protein mediated by the AP-4 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

Role of the clathrin terminal domain in regulating coated pit dynamics revealed by small molecule inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

Multiple GTP-binding proteins participate in clathrin-coated vesicle-mediated endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

Analysis of clathrin-mediated endocytosis of epidermal growth factor receptor by RNA interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

CALM, a clathrin assembly protein, influences cell surface GluR2 abundance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

Evidence for CALM in directing VAMP2 trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

A selective PIKfyve inhibitor blocks PtdIns(3,5)P(2) production and disrupts endomembrane transport and retroviral budding

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

Gamma-secretase complex assembly within the early secretory pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

Regulation of Notch signaling by dynamic changes in the precision of S3 cleavage of Notch-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

Effects of membrane lipids on the activity and processivity of purified γ-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

Spike bursts increase amyloid-β 40/42 ratio by inducing a presenilin-1 conformational change

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

Turning CALM into excitement: AP180 and CALM in endocytosis and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

A function for EHD family proteins in unidirectional retrograde dendritic transport of BACE1 and Alzheimer's disease Aβ production

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

A paired RNAi and RabGAP overexpression screen identifies Rab11 as a regulator of β-amyloid production

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

beta-Secretase inhibitor potency is decreased by aberrant beta-cleavage location of the "Swedish mutant" amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

APP processing and synaptic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

Specific domains in anterior pharynx-defective 1 determine its intramembrane interactions with nicastrin and presenilin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

Single chain variable fragment against nicastrin inhibits the gamma-secretase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

BACE1 activity is modulated by cell-associated sphingosine-1-phosphate.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid beta protein ending at the 42nd (or 43rd) residue

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

Equimolar production of amyloid beta-protein and amyloid precursor protein intracellular domain from beta-carboxyl-terminal fragment by gamma-secretase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

Protein trafficking and maturation regulate intramembrane proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

inferred from DOI database lookup

7 January 2021

based on heuristic

Nicastrin Is Required for Assembly of Presenilin/γ-Secretase Complexes to Mediate Notch Signaling and for Processing and Trafficking of β-Amyloid Precursor Protein in Mammals

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

inferred from DOI database lookup

7 January 2021

based on heuristic

Role of phosphorylation of Alzheimer's amyloid precursor protein during neuronal differentiation.

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS4386

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NCOMMS4386

2 references

Consolidated OpenCitations Corpus – April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24577224%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

7 June 2020

ADS bibcode

2014NatCo...5.3386K

0 references

1037787267

0 references

1 reference

Consolidated OpenCitations Corpus – April 2017

2 references

Consolidated OpenCitations Corpus – April 2017