(Q33759792)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21725355%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

title

Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin (English)

1 reference

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6 February 2020

1 reference

2

1 reference

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6 February 2020

Taisuke Tomita

15

1 reference

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6 February 2020

author name string

I Hayashi

1

1 reference

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6 February 2020

Y Urano

3

1 reference

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6 February 2020

Y Miyake

4

1 reference

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6 February 2020

J Takagi

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21725355%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

M Sakata-Yanagimoto

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21725355%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

H Iwanari

7

1 reference

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6 February 2020

S Osawa

8

1 reference

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6 February 2020

Y Morohashi

9

1 reference

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6 February 2020

T Li

10

1 reference

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6 February 2020

P C Wong

11

1 reference

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6 February 2020

S Chiba

12

1 reference

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6 February 2020

T Kodama

13

1 reference

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6 February 2020

T Hamakubo

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21725355%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

T Iwatsubo

16

1 reference

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6 February 2020

language of work or name

English

0 references

publication date

4 July 2011

1 reference

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6 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21725355%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

volume

31

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21725355%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

issue

6

1 reference

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6 February 2020

page(s)

787-798

1 reference

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https://scigraph.springernature.com/pub.10.1038/onc.2011.265

6 February 2020

exact match

0 references

cites work

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Therapeutic antibody targeting of individual Notch receptors

21 June 2018

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Notch signaling: emerging molecular targets for cancer therapy

21 June 2018

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Membrane rafts in Alzheimer's disease beta-amyloid production

21 June 2018

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Biological and clinical implications of nicastrin expression in invasive breast cancer

21 June 2018

1 reference

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A conserved tetraspanin subfamily promotes Notch signaling in Caenorhabditis elegans and in human cells

21 June 2018

1 reference

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The secretases: enzymes with therapeutic potential in Alzheimer disease

21 June 2018

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Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin

21 June 2018

1 reference

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The role of NOTCH1 signaling in T-ALL.

21 June 2018

1 reference

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Dual antitumor mechanisms of Notch signaling inhibitor in a T-cell acute lymphoblastic leukemia xenograft model.

21 June 2018

1 reference

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Preclinical profile of a potent gamma-secretase inhibitor targeting notch signaling with in vivo efficacy and pharmacodynamic properties

21 June 2018

1 reference

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Glu-333 of nicastrin directly participates in gamma-secretase activity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058788

Metalloprotease ADAM10 is required for Notch1 site 2 cleavage.

21 June 2018

1 reference

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Single chain variable fragment against nicastrin inhibits the gamma-secretase activity.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4058788

Secretase inhibitors and modulators for Alzheimer's disease treatment

21 June 2018

1 reference

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The canonical Notch signaling pathway: unfolding the activation mechanism

21 June 2018

1 reference

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Challenges in monoclonal antibody-based therapies

21 June 2018

1 reference

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Glu(332) in the Nicastrin ectodomain is essential for gamma-secretase complex maturation but not for its activity

21 June 2018

1 reference

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Viral envelope protein gp64 transgenic mouse facilitates the generation of monoclonal antibodies against exogenous membrane proteins displayed on baculovirus

21 June 2018

1 reference

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Activation of Notch signaling in tumorigenesis of experimental pancreatic cancer induced by dimethylbenzanthracene in mice

21 June 2018

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Notch pathway inhibition depletes stem-like cells and blocks engraftment in embryonal brain tumors

21 June 2018

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Isolation of membrane rafts and signaling complexes

21 June 2018

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Notch and Wnt inhibitors as potential new drugs for intestinal neoplastic disease

21 June 2018

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Recovery of functional peptide transporter PepT1 in budded baculovirus fraction

21 June 2018

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21 June 2018

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Processing of Notch and amyloid precursor protein by gamma-secretase is spatially distinct

21 June 2018

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21 June 2018

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Selective reconstitution and recovery of functional gamma-secretase complex on budded baculovirus particles

21 June 2018

1 reference

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A novel method for viral display of ER membrane proteins on budded baculovirus

21 June 2018

1 reference

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Nicastrin Is Required for Assembly of Presenilin/γ-Secretase Complexes to Mediate Notch Signaling and for Processing and Trafficking of β-Amyloid Precursor Protein in Mammals

21 June 2018

1 reference

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The role of presenilin cofactors in the gamma-secretase complex

21 June 2018

1 reference

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Gamma-secretase activity is associated with a conformational change of nicastrin

21 June 2018

1 reference

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Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane

21 June 2018

1 reference

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Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

21 June 2018

1 reference

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Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 June 2018

1 reference

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Crystal structure of the ectodomain of human transferrin receptor

21 June 2018

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Inhibition of gamma-secretase activity by helical beta-peptide foldamers.

21 June 2018

1 reference

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Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.265

A combinatorial G protein-coupled receptor reconstitution system on budded baculovirus. Evidence for Galpha and Galphao coupling to a human leukotriene B4 receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.265

Nicastrin functions as a gamma-secretase-substrate receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.265

Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.265

Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.265

Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.265

Analysis of the gamma-secretase interactome and validation of its association with tetraspanin-enriched microdomains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.265

ErbB-2 inhibition activates Notch-1 and sensitizes breast cancer cells to a gamma-secretase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.265

31 March 2020

Identifiers

DOI

10.1038/ONC.2011.265

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21725355%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

6 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21725355%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

PubMed publication ID

21725355

1 reference