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Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin
scientific journal article
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scholarly article
1 reference
stated in
PubMed
PubMed ID
20130175
retrieved
1 February 2017
title
Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin
(English)
1 reference
stated in
PubMed
PubMed ID
20130175
retrieved
1 February 2017
main subject
Presenilin enhancer gamma secretase subunit
1 reference
stated in
GOA release 2020-03-11
Aph1 homolog A, gamma secretase subunit
1 reference
stated in
GOA release 2020-03-11
Presenilin 1
1 reference
stated in
GOA release 2020-03-11
author name string
Guojun Zhao
series ordinal
1
1 reference
stated in
PubMed
PubMed ID
20130175
retrieved
1 February 2017
Zhenyi Liu
series ordinal
2
1 reference
stated in
PubMed
PubMed ID
20130175
retrieved
1 February 2017
Ma Xenia G. Ilagan
series ordinal
3
1 reference
stated in
PubMed
PubMed ID
20130175
retrieved
1 February 2017
Raphael Kopan
series ordinal
4
1 reference
stated in
PubMed
PubMed ID
20130175
retrieved
1 February 2017
language of work or name
English
0 references
publication date
3 February 2010
1 reference
stated in
PubMed
PubMed ID
20130175
retrieved
1 February 2017
published in
Journal of Neuroscience
1 reference
stated in
PubMed
PubMed ID
20130175
retrieved
1 February 2017
volume
30
1 reference
stated in
PubMed
PubMed ID
20130175
retrieved
1 February 2017
page(s)
1648–1656
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stated in
PubMed
PubMed ID
20130175
retrieved
1 February 2017
issue
5
1 reference
stated in
PubMed
PubMed ID
20130175
retrieved
1 February 2017
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Deficiency of Aph1B/C-gamma-secretase disturbs Nrg1 cleavage and sensorimotor gating that can be reversed with antipsychotic treatment
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Structural basis for autoinhibition of Notch
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Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components
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17 March 2017
APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development
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Nicastrin Is Required for Assembly of Presenilin/γ-Secretase Complexes to Mediate Notch Signaling and for Processing and Trafficking of β-Amyloid Precursor Protein in Mammals
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gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase
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17 March 2017
Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1
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17 March 2017
Calcium depletion dissociates and activates heterodimeric notch receptors
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17 March 2017
Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency
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A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
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17 March 2017
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
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17 March 2017
The canonical Notch signaling pathway: unfolding the activation mechanism
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7 April 2017
Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective
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7 April 2017
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity
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Amyloid precursor protein trafficking, processing, and function
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7 April 2017
Glu-333 of nicastrin directly participates in gamma-secretase activity
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29 September 2017
Metalloprotease ADAM10 is required for Notch1 site 2 cleavage.
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29 September 2017
Signal peptide peptidases: a family of intramembrane-cleaving proteases that cleave type 2 transmembrane proteins.
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29 September 2017
Secretase inhibitors and modulators for Alzheimer's disease treatment
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29 September 2017
gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease
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29 September 2017
Intramembrane-cleaving proteases
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29 September 2017
Notch and presenilin regulate cellular expansion and cytokine secretion but cannot instruct Th1/Th2 fate acquisition
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29 September 2017
Substrate-targeting gamma-secretase modulators
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29 September 2017
Glu(332) in the Nicastrin ectodomain is essential for gamma-secretase complex maturation but not for its activity
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PubMed Central
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29 September 2017
Gamma-secretase inhibition and modulation for Alzheimer's disease
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29 September 2017
Notch signaling in leukemia
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29 September 2017
Regulation of Notch signaling by dynamic changes in the precision of S3 cleavage of Notch-1
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29 September 2017
Presenilin: running with scissors in the membrane
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29 September 2017
Bi-compartmental communication contributes to the opposite proliferative behavior of Notch1-deficient hair follicle and epidermal keratinocytes.
1 reference
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PubMed Central
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29 September 2017
Cerebrospinal fluid tau/beta-amyloid(42) ratio as a prediction of cognitive decline in nondemented older adults
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PubMed Central
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29 September 2017
The multifaceted role of Notch in cancer
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PubMed Central
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29 September 2017
NOTCH signaling as a novel cancer therapeutic target
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PubMed Central
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29 September 2017
Nicastrin: gatekeeper of the gamma-secretase complex
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PubMed Central
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29 September 2017
Analysis of Notch function in presomitic mesoderm suggests a gamma-secretase-independent role for presenilins in somite differentiation.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2853942
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29 September 2017
The initial substrate-binding site of gamma-secretase is located on presenilin near the active site
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PubMed Central
reference URL
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29 September 2017
Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo
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PubMed Central
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29 September 2017
Identification of a new presenilin-dependent zeta-cleavage site within the transmembrane domain of amyloid precursor protein.
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PubMed Central
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29 September 2017
Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.
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29 September 2017
Assembly and activation of the γ-secretase complex: roles of presenilin cofactors
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PubMed Central
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29 September 2017
A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis
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PubMed Central
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29 September 2017
Back signaling by the Nrg-1 intracellular domain
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PubMed Central
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29 September 2017
Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration.
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PubMed Central
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29 September 2017
Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex
1 reference
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PubMed Central
reference URL
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29 September 2017
The role of presenilin cofactors in the gamma-secretase complex
1 reference
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PubMed Central
reference URL
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29 September 2017
Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases
1 reference
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PubMed Central
reference URL
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29 September 2017
aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2853942
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29 September 2017
Molecular dissection of domains in mutant presenilin 2 that mediate overproduction of amyloidogenic forms of amyloid beta peptides. Inability of truncated forms of PS2 with familial Alzheimer's disease mutation to increase secretion of Abeta42.
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PubMed Central
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29 September 2017
Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.
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PubMed Central
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29 September 2017
Selective reconstitution and recovery of functional gamma-secretase complex on budded baculovirus particles
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PubMed Central
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3 June 2018
Nicastrin binds to membrane-tethered Notch
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PubMed Central
reference URL
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3 June 2018
Nicastrin is dispensable for gamma-secretase protease activity in the presence of specific presenilin mutations
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2853942
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27 November 2018
Loss of nicastrin elicits an apoptotic phenotype in mouse embryos.
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PubMed Central
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27 November 2018
The GxGD motif of presenilin contributes to catalytic function and substrate identification of gamma-secretase.
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PubMed Central
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27 November 2018
Nicastrin functions as a gamma-secretase-substrate receptor
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2853942
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27 November 2018
Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1.
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PubMed Central
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27 November 2018
Reconstitution of gamma-secretase activity
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PubMed Central
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27 November 2018
Targeting presenilin-type aspartic protease signal peptide peptidase with gamma-secretase inhibitors
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PubMed Central
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27 November 2018
Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor.
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PubMed Central
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27 November 2018
Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1.
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PubMed Central
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27 November 2018
aph-2 encodes a novel extracellular protein required for GLP-1-mediated signaling.
1 reference
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PubMed Central
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27 November 2018
A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/20130175
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1523/JNEUROSCI.3826-09.2010
1 reference
stated in
PubMed
PubMed ID
20130175
retrieved
1 February 2017
PMCID
2853942
0 references
PubMed ID
20130175
1 reference
stated in
PubMed
PubMed ID
20130175
retrieved
1 February 2017
ResearchGate publication ID
41405113
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