(Q48833658)

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RhoA/ROCK pathway mediates p38 MAPK activation and morphological changes downstream of P2Y12/13 receptors in spinal microglia in neuropathic pain.

scientific article published on 14 August 2014

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scholarly article

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12 March 2020

RhoA/ROCK pathway mediates p38 MAPK activation and morphological changes downstream of P2Y12/13 receptors in spinal microglia in neuropathic pain (English)

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12 March 2020

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neuropathic pain

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(S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE

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ChEBI release 2020-05-28

4

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12 March 2020

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Koichi Noguchi

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12 March 2020

Kimiko Kobayashi

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Kimiko Kobayashi

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12 March 2020

Masafumi Sakagami

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Masafumi Sakagami

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12 March 2020

author name string

Emiko Tatsumi

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12 March 2020

Hiroki Yamanaka

2

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12 March 2020

publication date

14 August 2014

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12 March 2020

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12 March 2020

63

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12 March 2020

216-228

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12 March 2020

2

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12 March 2020

Spared nerve injury: an animal model of persistent peripheral neuropathic pain

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22745

21 January 2018

Cloning, pharmacological characterisation and distribution of the rat G-protein-coupled P2Y(13) receptor

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22745

21 January 2018

Involvement of spinal PKA/CREB signaling pathway in the development of bone cancer pain.

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22745

21 January 2018

Evidence that the purinergic receptor P2Y12 potentiates platelet shape change by a Rho kinase-dependent mechanism.

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22745

21 January 2018

Distribution of Rho-kinase in the bovine brain.

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22745

21 January 2018

Identification of the platelet ADP receptor targeted by antithrombotic drugs

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22745

21 January 2018

Gene pathway analysis of the mechanism by which the Rho-associated kinase inhibitor Y-27632 inhibits apoptosis in isolated thawed human embryonic stem cells

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22745

21 January 2018

MAP kinase and pain

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22745

21 January 2018

The effect of treatment with BRX-220, a co-inducer of heat shock proteins, on sensory fibers of the rat following peripheral nerve injury

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22745

21 January 2018

P2Y12 receptor upregulation in activated microglia is a gateway of p38 signaling and neuropathic pain

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22745

21 January 2018

Multiple P2Y subtypes in spinal microglia are involved in neuropathic pain after peripheral nerve injury

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22745

21 January 2018

Role of p38 and p44/42 mitogen-activated protein kinases in microglia

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22745

21 January 2018

Rho family GTPases and neuronal growth cone remodelling: relationship between increased complexity induced by Cdc42Hs, Rac1, and acetylcholine and collapse induced by RhoA and lysophosphatidic acid

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22745

21 January 2018

Enhanced phosphatidylinositol 4-phosphate 5-kinase alpha expression and PI(4,5)P2 production in LPS-stimulated microglia

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22745

21 January 2018

Release of BDNF and GABA in the dorsal horn of neuropathic rats

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22745

21 January 2018

Nerve injury-activated microglia engulf myelinated axons in a P2Y12 signaling-dependent manner in the dorsal horn

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22745

21 January 2018

RhoA/ROCK I signalling downstream of the P2Y13 ADP-receptor controls HDL endocytosis in human hepatocytes

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22745

21 January 2018

G13 is an essential mediator of platelet activation in hemostasis and thrombosis

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22745

21 January 2018

Dorsal root ganglion neurons show increased expression of the calcium channel alpha2delta-1 subunit following partial sciatic nerve injury.

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22745

21 January 2018

RhoA/Rho kinase pathway contributes to the pathogenesis of thermal hyperalgesia in diabetic mice.

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22745

21 January 2018

The obesity-associated peptide leptin induces hypertrophy in neonatal rat ventricular myocytes

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22745

21 January 2018

Rho GTPases regulate PRK2/PKN2 to control entry into mitosis and exit from cytokinesis

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22745

21 January 2018

Gi-dependent and -independent mechanisms downstream of the P2Y12 ADP-receptor

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22745

21 January 2018

Involvement of Rho-kinase in inflammatory and neuropathic pain through phosphorylation of myristoylated alanine-rich C-kinase substrate (MARCKS).

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22745

21 January 2018

Activated Rho kinase mediates diabetes-induced elevation of vascular arginase activation and contributes to impaired corpora cavernosa relaxation: possible involvement of p38 MAPK activation

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22745

21 January 2018

Activation of p38 mitogen-activated protein kinase in spinal hyperactive microglia contributes to pain hypersensitivity following peripheral nerve injury

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22745

21 January 2018

Alteration of the cell adhesion molecule L1 expression in a specific subset of primary afferent neurons contributes to neuropathic pain

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22745

21 January 2018

Leptin-induced cardiomyocyte hypertrophy involves selective caveolae and RhoA/ROCK-dependent p38 MAPK translocation to nuclei

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22745

21 January 2018

Essential role of Rho/ROCK-dependent processes and actin dynamics in mediating leptin-induced hypertrophy in rat neonatal ventricular myocytes.

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22745

21 January 2018

ADP is the cognate ligand for the orphan G protein-coupled receptor SP1999

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22745

21 January 2018

A critical role for a Rho-associated kinase, p160ROCK, in determining axon outgrowth in mammalian CNS neurons

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22745

7 January 2021

based on heuristic

inferred from DOI database lookup

p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain.

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22745

7 January 2021

based on heuristic

inferred from DOI database lookup

Neurons and glial cells differentially express P2Y receptor mRNAs in the rat dorsal root ganglion and spinal cord

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22745

7 January 2021

based on heuristic

inferred from DOI database lookup

Quantification of axotomy-induced alteration of neuropeptide mRNAs in dorsal root ganglion neurons with special reference to neuropeptide Y mRNA and the effects of neonatal capsaicin treatment

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22745

7 January 2021

based on heuristic

inferred from DOI database lookup

Increase of close homolog of cell adhesion molecule L1 in primary afferent by nerve injury and the contribution to neuropathic pain

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22745

7 January 2021

based on heuristic

inferred from DOI database lookup

Tissue plasminogen activator in primary afferents induces dorsal horn excitability and pain response after peripheral nerve injury

1 reference

https://api.crossref.org/works/10.1002%2FGLIA.22745

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1002/GLIA.22745

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25130721%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

1 reference

Europe PubMed Central

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12 March 2020

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