(Q49273526)

19 February 2018

title

NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair. (English)

1 reference

19 February 2018

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ataxia telangiectasia

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Morten Scheibye-Knudsen

4

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19 February 2018

Mark Mattson

20

object named as

Mark P Mattson

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19 February 2018

Vilhelm A. Bohr

22

object named as

Vilhelm A Bohr

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19 February 2018

author name string

Evandro Fei Fang

1

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19 February 2018

Henok Kassahun

2

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19 February 2018

Deborah L Croteau

3

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19 February 2018

Krisztina Marosi

5

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19 February 2018

Huiming Lu

6

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19 February 2018

Raghavendra A Shamanna

7

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19 February 2018

Sumana Kalyanasundaram

8

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19 February 2018

Ravi Chand Bollineni

9

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19 February 2018

Mark A Wilson

10

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19 February 2018

Wendy B Iser

11

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19 February 2018

Bradley N Wollman

12

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19 February 2018

Marya Morevati

13

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19 February 2018

Jun Li

14

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19 February 2018

Jesse S Kerr

15

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19 February 2018

Qiping Lu

16

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19 February 2018

Tyler B Waltz

17

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19 February 2018

Jane Tian

18

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19 February 2018

David A Sinclair

19

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19 February 2018

Hilde Nilsen

21

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19 February 2018

publication date

1 October 2016

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19 February 2018

published in

Cell Metabolism

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19 February 2018

volume

24

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19 February 2018

issue

4

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19 February 2018

page(s)

566-581

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19 February 2018

NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice

cites work

1 reference

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Nuclear DNA damage signalling to mitochondria in ageing

22 May 2018

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NAD⁺ in aging, metabolism, and neurodegeneration.

22 May 2018

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Mitochondrial SIRT3 Mediates Adaptive Responses of Neurons to Exercise and Metabolic and Excitatory Challenges

22 May 2018

1 reference

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Measuring In Vivo Mitophagy

22 May 2018

1 reference

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DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer

22 May 2018

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The multifaceted functions of sirtuins in cancer

22 May 2018

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NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

22 May 2018

1 reference

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Compromised autophagy and neurodegenerative diseases

22 May 2018

1 reference

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Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

22 May 2018

1 reference

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Mechanisms of ATM Activation

22 May 2018

1 reference

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A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome

22 May 2018

1 reference

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Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction.

22 May 2018

1 reference

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Maintaining genome stability in the nervous system

22 May 2018

1 reference

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The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

22 May 2018

1 reference

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SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5777858

The appropriateness of the mouse model for ataxia-telangiectasia: neurological defects but no neurodegeneration

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5777858

The role of ATM in the deficiency in nonhomologous end-joining near telomeres in a human cancer cell line

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5777858

A novel diagnostic tool reveals mitochondrial pathology in human diseases and aging

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5777858

The ATM protein kinase: regulating the cellular response to genotoxic stress, and more

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5777858

Evidence for a common mechanism of SIRT1 regulation by allosteric activators

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5777858

The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5777858

Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5777858

The atm-1 gene is required for genome stability in Caenorhabditis elegans

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5777858

Mitochondrial dysfunction in ataxia-telangiectasia

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5777858

SIRT6 promotes DNA repair under stress by activating PARP1

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5777858

Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5777858

DNA double-strand break repair in Caenorhabditis elegans

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5777858

ATM activation by oxidative stress

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5777858

A novel pathway regulates memory and plasticity via SIRT1 and miR-134

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5777858

Insulin signaling and dietary restriction differentially influence the decline of learning and memory with age

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5777858

22 May 2018

The genetics of ageing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5777858

SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5777858

Current and potential therapeutic strategies for the treatment of ataxia-telangiectasia.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5777858

Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5777858

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5777858

Cell cycle dependence of DNA-dependent protein kinase phosphorylation in response to DNA double strand breaks.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5777858

Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5777858

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5777858

Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5777858

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5777858

Accumulation of DNA damage and reduced levels of nicotine adenine dinucleotide in the brains of Atm-deficient mice

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5777858

Atm-deficient mice: a paradigm of ataxia telangiectasia

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5777858

mTORC1 and SIRT1 Cooperate to Foster Expansion of Gut Adult Stem Cells during Calorie Restriction.

22 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5777858

C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5777858

Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5777858

10.1016/J.CMET.2016.09.004

14 August 2018

Identifiers

DOI

1 reference

19 February 2018

release_hagkmzryajhl5j7mru3rd36gg4

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/hagkmzryajhl5j7mru3rd36gg4

mapped directly with Wikidata item

24 November 2022

based on heuristic

PMC publication ID

5777858

1 reference

19 February 2018

PubMed publication ID

27732836

1 reference

19 February 2018