(Q49796040)

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Next-generation, personalised, model-based critical care medicine: a state-of-the art review of in silico virtual patient models, methods, and cohorts, and how to validation them.

scientific article published on 20 February 2018

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14 November 2020

Next-generation, personalised, model-based critical care medicine: a state-of-the art review of in silico virtual patient models, methods, and cohorts, and how to validation them (English)

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Christopher Grant Pretty

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Jennifer L Dickson

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Antoine Pironet

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BioMedical Engineering OnLine

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Software-guided versus nurse-directed blood glucose control in critically ill patients: the LOGIC-2 multicenter randomized controlled clinical trial

1 reference

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22 May 2018

Autoregressive Modeling of Drift and Random Error to Characterize a Continuous Intravascular Glucose Monitoring Sensor

1 reference

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22 May 2018

Untangling glycaemia and mortality in critical care

1 reference

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22 May 2018

Modeling the Error of the Medtronic Paradigm Veo Enlite Glucose Sensor

1 reference

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22 May 2018

Effect of BGM Accuracy on the Clinical Performance of CGM: An In-Silico Study

1 reference

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22 May 2018

Feasibility of titrating PEEP to minimum elastance for mechanically ventilated patients

1 reference

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22 May 2018

In silico assessment of biomedical products: The conundrum of rare but not so rare events in two case studies

1 reference

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22 May 2018

Closing the Loop in Adults, Children and Adolescents With Suboptimally Controlled Type 1 Diabetes Under Free Living Conditions: A Psychosocial Substudy

1 reference

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22 May 2018

Generalisability of a Virtual Trials Method for Glycaemic Control in Intensive Care

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22 May 2018

Evaluation of a Predictive Low-Glucose Management System In-Clinic

1 reference

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22 May 2018

Feasibility of Long-Term Closed-Loop Control: A Multicenter 6-Month Trial of 24/7 Automated Insulin Delivery

1 reference

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22 May 2018

Extrapolation of a non-linear autoregressive model of pulmonary mechanics.

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22 May 2018

Real-World Use of Open Source Artificial Pancreas Systems

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22 May 2018

Roadmap for cardiovascular circulation model

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22 May 2018

The Virtual Physiological Human: The Physiome Project Aims to Develop Reproducible, Multiscale Models for Clinical Practice

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22 May 2018

Making sense of big data in health research: Towards an EU action plan

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22 May 2018

The Artificial Pancreas in 2016: A Digital Treatment Ecosystem for Diabetes

1 reference

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22 May 2018

Day-and-Night Closed-Loop Glucose Control in Patients With Type 1 Diabetes Under Free-Living Conditions: Results of a Single-Arm 1-Month Experience Compared With a Previously Reported Feasibility Study of Evening and Night at Home

1 reference

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22 May 2018

The Human Physiome: how standards, software and innovative service infrastructures are providing the building blocks to make it achievable.

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A physiome interoperability roadmap for personalized drug development.

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22 May 2018

Safety, efficacy and clinical generalization of the STAR protocol: a retrospective analysis

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22 May 2018

One-Day Bayesian Cloning of Type 1 Diabetes Subjects: Toward a Single-Day UVA/Padova Type 1 Diabetes Simulator

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22 May 2018

Modeling Transient Disconnections and Compression Artifacts of Continuous Glucose Sensors

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22 May 2018

Space GlucoseControl system for blood glucose control in intensive care patients--a European multicentre observational study

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Evidence-based medicine: is it a bridge too far?

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22 May 2018

The CellML Metadata Framework 2.0 Specification.

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22 May 2018

2 month evening and night closed-loop glucose control in patients with type 1 diabetes under free-living conditions: a randomised crossover trial

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22 May 2018

Home Use of an Artificial Beta Cell in Type 1 Diabetes

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22 May 2018

Understanding central venous pressure: not a preload index?

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22 May 2018

Future opportunities and trends for e-infrastructures and life sciences: going beyond the grid to enable life science data analysis

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22 May 2018

Time in blood glucose range 70 to 140 mg/dl >80% is strongly associated with increased survival in non-diabetic critically ill adults

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22 May 2018

Model-based computation of total stressed blood volume from a preload reduction manoeuvre

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22 May 2018

Predictors of the accuracy of pulse-contour cardiac index and suggestion of a calibration-index: a prospective evaluation and validation study

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22 May 2018

Impact of Haemodialysis on Insulin Kinetics of Acute Kidney Injury Patients in Critical Care.

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22 May 2018

A mathematical model approach quantifying patients' response to changes in mechanical ventilation: evaluation in volume support.

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22 May 2018

Glucose control positively influences patient outcome: A retrospective study

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22 May 2018

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22 May 2018

Choices in fluid type and volume during resuscitation: impact on patient outcomes

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22 May 2018

Time-varying respiratory system elastance: a physiological model for patients who are spontaneously breathing

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22 May 2018

Multicenter outpatient dinner/overnight reduction of hypoglycemia and increased time of glucose in target with a wearable artificial pancreas using modular model predictive control in adults with type 1 diabetes.

1 reference

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22 May 2018

The impact of measurement frequency on the domains of glycemic control in the critically ill--a Monte Carlo simulation

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Assessing volume status

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22 May 2018

Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine.

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Positive end-expiratory pressure and variable ventilation in lung-healthy rats under general anesthesia

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Evolution of insulin sensitivity and its variability in out-of-hospital cardiac arrest (OHCA) patients treated with hypothermia

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The Clinical Utilisation of Respiratory Elastance Software (CURE Soft): a bedside software for real-time respiratory mechanics monitoring and mechanical ventilation management

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22 May 2018

Modeling of effect of glucose sensor errors on insulin dosage and glucose bolus computed by LOGIC-Insulin.

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22 May 2018

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22 May 2018

Continuous glucose control in the ICU: report of a 2013 round table meeting

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22 May 2018

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22 May 2018

The artificial pancreas: a digital-age treatment for diabetes

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22 May 2018

Safety of outpatient closed-loop control: first randomized crossover trials of a wearable artificial pancreas

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22 May 2018

Continuous glucose monitoring in newborn infants: how do errors in calibration measurements affect detected hypoglycemia?

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22 May 2018

Reducing the impact of insulin sensitivity variability on glycaemic outcomes using separate stochastic models within the STAR glycaemic protocol

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22 May 2018

Reverse engineering cellular networks with information theoretic methods.

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22 May 2018

Visualisation of time-varying respiratory system elastance in experimental ARDS animal models

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22 May 2018

A vision and strategy for the virtual physiological human: 2012 update.

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22 May 2018

Reverse engineering and identification in systems biology: strategies, perspectives and challenges

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22 May 2018

Model-based measurement of gas exchange in healthy subjects using ALPE essential--influence of age, posture and gender.

1 reference

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22 May 2018

Modeling the glucose sensor error

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22 May 2018

On the problem of patient-specific endogenous glucose production in neonates on stochastic targeted glycemic control

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22 May 2018

FieldML, a proposed open standard for the Physiome project for mathematical model representation

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22 May 2018

In silico modeling: methods and applications to trauma and sepsis

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22 May 2018

Human factors systems approach to healthcare quality and patient safety

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22 May 2018

Effects of Neurally Adjusted Ventilatory Assist (NAVA) levels in non-invasive ventilated patients: titrating NAVA levels with electric diaphragmatic activity and tidal volume matching

1 reference

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22 May 2018

Expiratory model-based method to monitor ARDS disease state.

1 reference

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22 May 2018

Nasogastric aspiration as an indicator for feed absorption in model-based glycemic control in neonatal intensive care

1 reference

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22 May 2018

Evaluation of a model-based hemodynamic monitoring method in a porcine study of septic shock.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Pulmonary artery catheters for adult patients in intensive care

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Daily evolution of insulin sensitivity variability with respect to diagnosis in the critically ill.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Analysis of different model-based approaches for estimating dFRC for real-time application

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

A multi-scale cardiovascular system model can account for the load-dependence of the end-systolic pressure-volume relationship

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Real-time improvement of continuous glucose monitoring accuracy: the smart sensor concept

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Glycemic levels in critically ill patients: are normoglycemia and low variability associated with improved outcomes?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Fluid use in adult intensive care

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

LOGIC-insulin algorithm-guided versus nurse-directed blood glucose control during critical illness: the LOGIC-1 single-center, randomized, controlled clinical trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

STAR development and protocol comparison.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Pilot study of a model-based approach to blood glucose control in very-low-birthweight neonates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Systems modeling and simulation applications for critical care medicine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Variability of insulin sensitivity during the first 4 days of critical illness: implications for tight glycemic control

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

The PiCCO monitor: a review.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Stochastic targeted (STAR) glycemic control: design, safety, and performance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Use of models in identification and prediction of physiology in critically ill surgical patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

A spectrum of dynamic insulin sensitivity test protocols

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Model-based PEEP optimisation in mechanical ventilation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Cardiac Output Measurements in Septic Patients: Comparing the Accuracy of USCOM to PiCCO

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Inotropes and vasopressors: more than haemodynamics!

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

ICU capacity strain and the quality and allocation of critical care

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Pilot proof of concept clinical trials of Stochastic Targeted (STAR) glycemic control

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Physiological modeling, tight glycemic control, and the ICU clinician: what are models and how can they affect practice?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Model-based optimal PEEP in mechanically ventilated ARDS patients in the intensive care unit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

OpenCMISS: a multi-physics & multi-scale computational infrastructure for the VPH/Physiome project.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

A graphical method for practical and informative identifiability analyses of physiological models: a case study of insulin kinetics and sensitivity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Multi-scale lung modeling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

A physiological Intensive Control Insulin-Nutrition-Glucose (ICING) model validated in critically ill patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Development of blood glucose control for extremely premature infants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

An updated study-level meta-analysis of randomised controlled trials on proning in ARDS and acute lung injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Validation of a model-based virtual trials method for tight glycemic control in intensive care.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Tight glycemic control in critical care--the leading role of insulin sensitivity and patient variability: a review and model-based analysis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Image-based modeling of lung structure and function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Toward a VPH/Physiome ToolKit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

The lung physiome: merging imaging-based measures with predictive computational models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Continuous glucose monitors and the burden of tight glycemic control in critical care: can they cure the time cost?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Human factors in the management of the critically ill patient

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Sharing and reusing cardiovascular anatomical models over the Web: a step towards the implementation of the virtual physiological human project

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

A vision and strategy for the virtual physiological human in 2010 and beyond.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Cardiac cell modelling: observations from the heart of the cardiac physiome project

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Parameter estimation and model selection in computational biology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Hypoglycemia and outcome in critically ill patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Bedside assessment of mean systemic filling pressure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Simulation environment to evaluate closed-loop insulin delivery systems in type 1 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Hypoglycemia detection in critical care using continuous glucose monitors: an in silico proof of concept analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Modeling the error of continuous glucose monitoring sensor data: critical aspects discussed through simulation studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Blood glucose controller for neonatal intensive care: virtual trials development and first clinical trials

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Reducing glycemic variability in intensive care unit patients: a new therapeutic target?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Physical activity into the meal glucose-insulin model of type 1 diabetes: in silico studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Real-time continuous glucose monitoring in critically ill patients: a prospective randomized trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Inotrope and vasopressor therapy of septic shock

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

A benchmark data set for model-based glycemic control in critical care

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

In silico testing--impact on the progress of the closed loop insulin infusion for critically ill patients project

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Impact of human factors on clinical protocol performance: a proposed assessment framework and case examples

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Can the costs of critical care be controlled?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Analysis, modeling, and simulation of the accuracy of continuous glucose sensors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Using a human cardiovascular-respiratory model to characterize cardiac tamponade and pulsus paradoxus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Techniques for assessment of intravascular volume in critically ill patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Validation of continuous cardiac output technologies: consensus still awaited

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Serum resistin levels in critically ill patients are associated with inflammation, organ dysfunction and metabolism and may predict survival of non-septic patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

The impact of early hypoglycemia and blood glucose variability on outcome in critical illness

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Towards closed-loop glycaemic control

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

In silico preclinical trials: a proof of concept in closed-loop control of type 1 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

FieldML: concepts and implementation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Comparison of three protocols for tight glycemic control in cardiac surgery patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

A new library of HEMET model: Insulin effects on hepatic metabolism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

The Swan-Ganz catheters: past, present, and future. A viewpoint

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

The Cardiac Physiome: perspectives for the future

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Ability of dynamic airway pressure curve profile and elastance for positive end-expiratory pressure titration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Comparison of functional residual capacity and static compliance of the respiratory system during a positive end-expiratory pressure (PEEP) ramp procedure in an experimental model of acute respiratory distress syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

CellML and associated tools and techniques

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Bioinformatics, multiscale modeling and the IUPS Physiome Project

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Pulmonary artery catheters: state of the controversy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Multicenter, randomized, controlled trials evaluating mortality in intensive care: doomed to fail?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Interventions for carotid artery disease: time to confront some 'inconvenient truths'.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Feasibility, limits and problems of clinical studies in Intensive Care Unit

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Clinical assessment and mathematical modeling of the accuracy of continuous glucose sensors (CGS).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Volume responsiveness

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

DAISY: a new software tool to test global identifiability of biological and physiological systems

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Positive end-expiratory pressure at minimal respiratory elastance represents the best compromise between mechanical stress and lung aeration in oleic acid induced lung injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Hemodynamic monitoring in shock and implications for management. International Consensus Conference, Paris, France, 27-28 April 2006.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

A system model of oral glucose absorption: validation on gold standard data

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Effects of descending positive end-expiratory pressure on lung mechanics and aeration in healthy anaesthetized piglets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Beyond 'faith-based medicine' and EBM.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Variability of blood glucose concentration and short-term mortality in critically ill patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Rethinking sedation and agitation management in critical illness.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

A human factors engineering conceptual framework of nursing workload and patient safety in intensive care units

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

A strategy for integrative computational physiology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Reduced sampling schedule for the glucose minimal model: importance of Bayesian estimation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Daily cost of an intensive care unit day: the contribution of mechanical ventilation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Integration from proteins to organs: the IUPS Physiome Project

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Minimal haemodynamic system model including ventricular interaction and valve dynamics.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

An update on cost-effectiveness analysis in critical care

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

U.S. health care in conflict--Part I. The challenges of balancing cost, quality and access.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Evidence-based medicine: how good is the evidence?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Global identifiability of nonlinear models of biological systems.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Pulmonary artery catheterization and clinical outcomes: National Heart, Lung, and Blood Institute and Food and Drug Administration Workshop Report. Consensus Statement

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Computation of aortic flow from pressure in humans using a nonlinear, three-element model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

AIDA2: a Mk. II automated insulin dosage advisor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Validation of simple and complex models in physiology and medicine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Estimation of insulin sensitivity and glucose clearance from minimal model: new insights from labeled IVGTT.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

An anatomical heart model with applications to myocardial activation and ventricular mechanics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Quantitative estimation of insulin sensitivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

22 May 2018

Continuous Glucose Monitoring Measures Can Be Used for Glycemic Control in the ICU: An In-Silico Study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Type 1 diabetes patient decision simulator for in silico testing safety and effectiveness of insulin treatments.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Closed-loop insulin delivery in inpatients with type 2 diabetes: a randomised, parallel-group trial.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

The Virtual Physiological Human: Ten Years After.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Task management skills and their deficiencies during care delivery in simulated medical emergency situation: A classification.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Breathing Easier: Model-based decision support for respiratory care looks beyond tomorrow.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Organizational factors impacting job strain and mental quality of life in emergency and critical care units.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Online Calibration of Glucose Sensors From the Measured Current by a Time-Varying Calibration Function and Bayesian Priors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Public views on principles for health care priority setting: findings of a European cross-country study using Q methodology.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Model of glucose sensor error components: identification and assessment for new Dexcom G4 generation devices

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Determination of 'recruited volume' following a PEEP step is not a measure of lung recruitability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Brain mass estimation by head circumference and body mass methods in neonatal glycaemic modelling and control.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Does the achievement of an intermediate glycemic target reduce organ failure and mortality? A post hoc analysis of the Glucontrol trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Simulating physiological interactions in a hybrid system of mathematical models.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Efficient computation of interacting model systems.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Hypoglycemia and risk of death in critically ill patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Structural identifiability and practical applicability of an alveolar recruitment model for ARDS patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Pilot studies of wearable outpatient artificial pancreas in type 1 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Decision support for optimized blood glucose control and nutrition in a neurotrauma intensive care unit: preliminary results of clinical advice and prediction accuracy of the Glucosafe system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Lung elastance and transpulmonary pressure can be determined without using oesophageal pressure measurements.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Volume-independent elastance: a useful parameter for open-lung positive end-expiratory pressure adjustment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Assessment of ventricular contractility and ventricular-arterial coupling with a model-based sensor.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Characterisation of the iterative integral parameter identification method.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

The Intelligent Ventilator (INVENT) project: the role of mathematical models in translating physiological knowledge into clinical practice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Validation of subject-specific cardiovascular system models from porcine measurements.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Impact of variation in patient response on model-based control of glycaemia in critically ill patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Dynamically generated models for medical decision support systems.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Increased blood glucose variability during therapeutic hypothermia and outcome after cardiac arrest.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

The dynamic insulin sensitivity and secretion test--a novel measure of insulin sensitivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Evaluating glycemic control algorithms by computer simulations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Failure to achieve euglycemia despite aggressive insulin control signals abnormal physiologic response to trauma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

The Physiome Model Repository 2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

The cardiac physiome: foundations and future prospects for mathematical modelling of the heart.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

We should abandon randomized controlled trials in the intensive care unit.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Customized in silico population mimics actual population in docetaxel population pharmacokinetic analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Using human factors engineering to improve the effectiveness of infection prevention and control.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Development of a model-based clinical sepsis biomarker for critically ill patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Pulmonary mechanics: a system identification perspective.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

The Glucosafe system for tight glycemic control in critical care: a pilot evaluation study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

A simulation model of insulin saturation and glucose balance for glycemic control in ICU patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Assessment of venous return curve and mean systemic filling pressure in postoperative cardiac surgery patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Model-based identification and diagnosis of a porcine model of induced endotoxic shock with hemofiltration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

A simulation model of glucose regulation in the critically ill.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

A replicable method for blood glucose control in critically Ill patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Guidelines have done more harm than good

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Model-based insulin and nutrition administration for tight glycaemic control in critical care.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Identification of IVGTT minimal glucose model by nonlinear mixed-effects approaches

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

A minimal model for glycemia control in critically ill patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Automated glucose control in the ICU: effect of nutritional protocol and measurement error

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Measurement of cardiac output: a comparison between transpulmonary thermodilution and uncalibrated pulse contour analysis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Stochastic modelling of insulin sensitivity and adaptive glycemic control for critical care.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Development of a physiology-based whole-body population model for assessing the influence of individual variability on the pharmacokinetics of drugs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Use of dynamic compliance for open lung positive end-expiratory pressure titration in an experimental study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Using physiological models and decision theory for selecting appropriate ventilator settings.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

A pilot study of the SPRINT protocol for tight glycemic control in critically Ill patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Transient and steady-state euglycemic clamp validation of a model for glycemic control and insulin sensitivity testing.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

A simple insulin-nutrition protocol for tight glycemic control in critical illness: development and protocol comparison.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Integral-based filtering of continuous glucose sensor measurements for glycaemic control in critical care.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Cost analysis of intensive glycemic control in critically ill adult patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

A new dynamic index of insulin sensitivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Rationing in the intensive care unit.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Evaluation of nonlinear regression approaches to estimation of insulin sensitivity by the minimal model with reference to Bayesian hierarchical analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Multicentric, randomized, controlled trial to evaluate blood glucose control by the model predictive control algorithm versus routine glucose management protocols in intensive care unit patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Computational models of structure-function relationships in the pulmonary circulation and their validation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

An imaging-based computational approach to model ventilation distribution and soft-tissue deformation in the ovine lung.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Physiological modelling of agitation-sedation dynamics including endogenous agitation reduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Effects of norepinephrine on static and dynamic preload indicators in experimental hemorrhagic shock

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Simplified models for gas exchange in the human lungs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Insulin sensitivity by oral glucose minimal models: validation against clamp

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Physiological modelling of agitation-sedation dynamics.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Comparative evaluation of simple insulin sensitivity methods based on the oral glucose tolerance test

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Integral-based parameter identification for long-term dynamic verification of a glucose-insulin system model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Insulin minimal model indexes and secretion: proper handling of uncertainty by a Bayesian approach

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Bayesian two-compartment and classic single-compartment minimal models: comparison on insulin modified IVGTT and effect of experiment reduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Numerical non-identifiability regions of the minimal model of glucose kinetics: superiority of Bayesian estimation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Structural identifiability for a class of non-linear compartmental systems using linear/non-linear splitting and symbolic computation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

The hot IVGTT two-compartment minimal model: an improved version

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

The automatic lung parameter estimator (ALPE) system: non-invasive estimation of pulmonary gas exchange parameters in 10-15 minutes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

The oral glucose minimal model: estimation of insulin sensitivity from a meal test

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Partitioning glucose distribution/transport, disposal, and endogenous production during IVGTT.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Generalized sensitivity functions in physiological system identification.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Minimal model SG overestimation and SI underestimation: improved accuracy by a Bayesian two-compartment model.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

SAAM II: Simulation, Analysis, and Modeling Software for tracer and pharmacokinetic studies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Global identifiability of linear compartmental models--a computer algebra algorithm.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

14 August 2018

Impact of sensor and measurement timing errors on model-based insulin sensitivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

30 November 2018

Visualisation of Time-Variant Respiratory System Elastance in ARDS Models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

30 November 2018

Impact of glucocorticoids on insulin resistance in the critically ill

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

30 November 2018

Pulmonary Gas Exchange in Anatomically-Based Models of the Lung

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

30 November 2018

Effect of Intensive Insulin Therapy on Insulin Sensitivity in the Critically Ill

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5819676

30 November 2018

A probabilistic approach to glucose prediction and insulin dose adjustment: description of metabolic model and pilot evaluation study

1 reference

https://pubmed.ncbi.nlm.nih.gov/29463246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modern critical care unit design. Nursing implications in modern critical care unit design: bed area ergonomics

1 reference

https://pubmed.ncbi.nlm.nih.gov/29463246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Time-domain representation of ventricular-arterial coupling as a windkessel and wave system

1 reference

https://pubmed.ncbi.nlm.nih.gov/29463246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of healthcare resource utilization with intensive insulin therapy in critically ill patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/29463246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of nursing work effort and perceptions about blood glucose testing in tight glycemic control

1 reference

https://pubmed.ncbi.nlm.nih.gov/29463246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multi-scale models of the lung airways and vascular system

1 reference

https://pubmed.ncbi.nlm.nih.gov/29463246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Patient specific identification of the cardiac driver function in a cardiovascular system model

1 reference

https://pubmed.ncbi.nlm.nih.gov/29463246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolic and clinical effects of the supplementation of a functional mixture of amino acids in cerebral hemorrhage

1 reference

https://pubmed.ncbi.nlm.nih.gov/29463246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Constant cardiac output monitoring using the PiCCO and LiDCO methods versus PAK in septic patients: when to do calibration?

1 reference

https://pubmed.ncbi.nlm.nih.gov/29463246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bedside assessment of total systemic vascular compliance, stressed volume, and cardiac function curves in intensive care unit patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/29463246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Individualized PEEP setting in subjects with ARDS: a randomized controlled pilot study

1 reference

https://pubmed.ncbi.nlm.nih.gov/29463246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyperglycaemic Preterm Babies Have Sex Differences in Insulin Secretion

1 reference

https://pubmed.ncbi.nlm.nih.gov/29463246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The CellML Metadata Framework 2.0 Specification.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29463246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Improved survival in critically ill patients: are large RCTs more useful than personalized medicine? No

1 reference

https://pubmed.ncbi.nlm.nih.gov/29463246

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/S12938-018-0455-Y

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29463246%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

Dimensions Publication ID

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/s12938-018-0455-y

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29463246%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29463246%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

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