(Q50063845)

English

NAD+ supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency.

scientific article published on 5 February 2018

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scholarly article

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Europe PubMed Central

PubMed publication ID

24 February 2018

http://europepmc.org/abstract/MED/29432159

NAD+ supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency. (English)

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Europe PubMed Central

PubMed publication ID

24 February 2018

http://europepmc.org/abstract/MED/29432159

Alzheimer's disease

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object named as

Yujun Hou

1

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object named as

Sofie Lautrup

2

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12

object named as

Mark P Mattson

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Europe PubMed Central

PubMed publication ID

24 February 2018

http://europepmc.org/abstract/MED/29432159

Vilhelm A. Bohr

13

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Vilhelm A Bohr

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Europe PubMed Central

PubMed publication ID

24 February 2018

http://europepmc.org/abstract/MED/29432159

author name string

Stephanie Cordonnier

3

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Europe PubMed Central

PubMed publication ID

24 February 2018

http://europepmc.org/abstract/MED/29432159

Yue Wang

4

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Europe PubMed Central

PubMed publication ID

24 February 2018

http://europepmc.org/abstract/MED/29432159

Deborah L Croteau

5

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Europe PubMed Central

PubMed publication ID

24 February 2018

http://europepmc.org/abstract/MED/29432159

Eduardo Zavala

6

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Europe PubMed Central

PubMed publication ID

24 February 2018

http://europepmc.org/abstract/MED/29432159

Yongqing Zhang

7

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Europe PubMed Central

PubMed publication ID

24 February 2018

http://europepmc.org/abstract/MED/29432159

Kanako Moritoh

8

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Europe PubMed Central

PubMed publication ID

24 February 2018

http://europepmc.org/abstract/MED/29432159

Jennifer F O'Connell

9

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Europe PubMed Central

PubMed publication ID

24 February 2018

http://europepmc.org/abstract/MED/29432159

Beverly A Baptiste

10

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Europe PubMed Central

PubMed publication ID

24 February 2018

http://europepmc.org/abstract/MED/29432159

Tinna V Stevnsner

11

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Europe PubMed Central

PubMed publication ID

24 February 2018

http://europepmc.org/abstract/MED/29432159

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publication date

5 February 2018

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Europe PubMed Central

PubMed publication ID

24 February 2018

http://europepmc.org/abstract/MED/29432159

Proceedings of the National Academy of Sciences of the United States of America

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Europe PubMed Central

PubMed publication ID

24 February 2018

http://europepmc.org/abstract/MED/29432159

115

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Europe PubMed Central

PubMed publication ID

24 February 2018

http://europepmc.org/abstract/MED/29432159

8

1 reference

Europe PubMed Central

PubMed publication ID

24 February 2018

http://europepmc.org/abstract/MED/29432159

E1876-E1885

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Europe PubMed Central

PubMed publication ID

24 February 2018

http://europepmc.org/abstract/MED/29432159

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5828618/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Neuroprotective Functions for the Histone Deacetylase SIRT6

1 reference

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1 reference

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26 August 2018

NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation.

1 reference

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26 August 2018

NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair.

1 reference

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26 August 2018

Nicotinamide riboside is uniquely and orally bioavailable in mice and humans

1 reference

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26 August 2018

DNA polymerase β decrement triggers death of olfactory bulb cells and impairs olfaction in a mouse model of Alzheimer's disease

1 reference

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2016 Alzheimer's disease facts and figures

1 reference

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Bioenergetic Impairment in Animal and Cellular Models of Alzheimer's Disease: PARP-1 Inhibition Rescues Metabolic Dysfunctions.

1 reference

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26 August 2018

Slowing ageing by design: the rise of NAD(+) and sirtuin-activating compounds

1 reference

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26 August 2018

Loss of NAD Homeostasis Leads to Progressive and Reversible Degeneration of Skeletal Muscle

1 reference

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26 August 2018

Nicotinamide Riboside Opposes Type 2 Diabetes and Neuropathy in Mice

1 reference

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26 August 2018

Nicotinamide mononucleotide protects against β-amyloid oligomer-induced cognitive impairment and neuronal death

1 reference

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26 August 2018

NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice

1 reference

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26 August 2018

Genome instability in Alzheimer disease.

1 reference

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26 August 2018

NAD⁺ in aging, metabolism, and neurodegeneration.

1 reference

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26 August 2018

Mitochondrial SIRT3 Mediates Adaptive Responses of Neurons to Exercise and Metabolic and Excitatory Challenges

1 reference

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26 August 2018

The Reactome pathway Knowledgebase

1 reference

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26 August 2018

Genomic integrity and the ageing brain

1 reference

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26 August 2018

NAD(+) Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

1 reference

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26 August 2018

Nicotinamide Riboside Ameliorates Hepatic Metaflammation by Modulating NLRP3 Inflammasome in a Rodent Model of Type 2 Diabetes.

1 reference

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26 August 2018

Effect of nicotinamide mononucleotide on brain mitochondrial respiratory deficits in an Alzheimer's disease-relevant murine model

1 reference

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26 August 2018

PARP-1 involvement in neurodegeneration: A focus on Alzheimer's and Parkinson's diseases.

1 reference

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26 August 2018

DNA polymerase β deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5828618

26 August 2018

Activation of SIRT3 by the NAD⁺ precursor nicotinamide riboside protects from noise-induced hearing loss

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5828618

26 August 2018

A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome

1 reference

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26 August 2018

Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction.

1 reference

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26 August 2018

Partial reversal of skeletal muscle aging by restoration of normal NAD⁺ levels

1 reference

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26 August 2018

Object recognition test in mice.

1 reference

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26 August 2018

Nucleic acid oxidation: an early feature of Alzheimer's disease

1 reference

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26 August 2018

Tau pathology and neurodegeneration

1 reference

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26 August 2018

Differential relationships of reactive astrocytes and microglia to fibrillar amyloid deposits in Alzheimer disease

1 reference

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26 August 2018

Modulation of DNA base excision repair during neuronal differentiation

1 reference

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Crosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes

1 reference

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26 August 2018

Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models

1 reference

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A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease

1 reference

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1 reference

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26 August 2018

Sporadic Alzheimer disease fibroblasts display an oxidative stress phenotype

1 reference

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Down syndrome as a model of DNA polymerase beta haploinsufficiency and accelerated aging

1 reference

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26 August 2018

DNA repair deficiency in neurodegeneration.

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1 reference

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CCR6: a biomarker for Alzheimer's-like disease in a triple transgenic mouse model

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26 August 2018

DNA damage and impairment of DNA repair in Alzheimer's disease

1 reference

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26 August 2018

Gait and balance impairments in Alzheimer disease patients

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Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain.

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DNA polymerase beta-catalyzed-PCNA independent long patch base excision repair synthesis: a mechanism for repair of oxidatively damaged DNA ends in post-mitotic brain

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26 August 2018

Oxidative DNA damage in mild cognitive impairment and late-stage Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5828618

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Defective DNA base excision repair in brain from individuals with Alzheimer's disease and amnestic mild cognitive impairment

1 reference

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Morris water maze: procedures for assessing spatial and related forms of learning and memory

1 reference

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DNA polymerase-beta is expressed early in neurons of Alzheimer's disease brain and is loaded into DNA replication forks in neurons challenged with beta-amyloid.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5828618

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5828618

26 August 2018

Increased oxidative damage in nuclear and mitochondrial DNA in mild cognitive impairment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5828618

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PAGE: parametric analysis of gene set enrichment

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Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase

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Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

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Differential diagnosis of Alzheimer disease with cerebrospinal fluid levels of tau protein phosphorylated at threonine 231.

1 reference

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

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Functions of poly(ADP-ribose) polymerase (PARP) in DNA repair, genomic integrity and cell death

1 reference

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Increased poly(ADP-ribosyl)ation of nuclear proteins in Alzheimer's disease.

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Repair of oxidative damage to nuclear and mitochondrial DNA in mammalian cells

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Nicotinamide adenine dinucleotide (NADH)--a new therapeutic approach to Parkinson's disease. Comparison of oral and parenteral application

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CELL METABOLISM. The resurgence of NAD⁺

1 reference

https://pubmed.ncbi.nlm.nih.gov/29432159

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1073/PNAS.1718819115

1 reference

Europe PubMed Central

PubMed publication ID

24 February 2018

http://europepmc.org/abstract/MED/29432159

PMC publication ID

0 references

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

24 February 2018

http://europepmc.org/abstract/MED/29432159

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