(Q50086506)

English

FREQUENT SUBCLINICAL MACULAR CHANGES IN COMBINED BRAF/MEK INHIBITION WITH HIGH-DOSE HYDROXYCHLOROQUINE AS TREATMENT FOR ADVANCED METASTATIC BRAF MUTANT MELANOMA: Preliminary Results From a Phase I/II Clinical Treatment Trial.

scientific article published on 10 January 2018

FREQUENT SUBCLINICAL MACULAR CHANGES IN COMBINED BRAF/MEK INHIBITION WITH HIGH-DOSE HYDROXYCHLOROQUINE AS TREATMENT FOR ADVANCED METASTATIC BRAF MUTANT MELANOMA: Preliminary Results From a Phase I/II Clinical Treatment Trial

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scholarly article

1 reference

Europe PubMed Central

24 February 2018

http://europepmc.org/abstract/MED/29324592

FREQUENT SUBCLINICAL MACULAR CHANGES IN COMBINED BRAF/MEK INHIBITION WITH HIGH-DOSE HYDROXYCHLOROQUINE AS TREATMENT FOR ADVANCED METASTATIC BRAF MUTANT MELANOMA: Preliminary Results From a Phase I/II Clinical Treatment Trial. (English)

1 reference

Europe PubMed Central

24 February 2018

http://europepmc.org/abstract/MED/29324592

phase II clinical trial

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phase I clinical trial

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hydroxychloroquine

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based on heuristic

inferred from title

Katherine E Uyhazi

4

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4 June 2020

Tara C Gangadhar

9

object named as

Tara C Gangadhar

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4 June 2020

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Akosua A Nti

1

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4 June 2020

Leona W Serrano

2

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4 June 2020

Harpal S Sandhu

3

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Ilaina D Edelstein

5

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Elaine J Zhou

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Scott Bowman

7

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Delu Song

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Lynn M Schuchter

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Sheryl Mitnick

11

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Alexander Huang

12

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Charles W Nichols

13

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Ravi K Amaravadi

14

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Benjamin J Kim

15

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Tomas S Aleman

16

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10 January 2018

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39

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502-513

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Clinical and Morphologic Characteristics of MEK Inhibitor-Associated Retinopathy: Differences from Central Serous Chorioretinopathy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6039280

26 August 2018

Mechanisms and strategies to overcome resistance to molecularly targeted therapy for melanoma

1 reference

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26 August 2018

Incidence, course, and management of toxicities associated with cobimetinib in combination with vemurafenib in the coBRIM study

1 reference

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26 August 2018

Targeting the unfolded protein response in cancer

1 reference

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26 August 2018

Targeted agents and immunotherapies: optimizing outcomes in melanoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6039280

26 August 2018

Immune checkpoint inhibitors and targeted therapies for metastatic melanoma: A network meta-analysis.

1 reference

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26 August 2018

Natural History of the Central Structural Abnormalities in Choroideremia: A Prospective Cross-Sectional Study

1 reference

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26 August 2018

Enhanced Visualization of Subtle Outer Retinal Pathology by En Face Optical Coherence Tomography and Correlation with Multi-Modal Imaging

1 reference

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26 August 2018

Research progress of hydroxychloroquine and autophagy inhibitors on cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6039280

26 August 2018

Evaluating outer segment length as a surrogate measure of peak foveal cone density

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6039280

26 August 2018

Activating autophagy to potentiate immunogenic chemotherapy and radiation therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6039280

26 August 2018

Pembrolizumab-triggered Uveitis: An Additional Surrogate Marker for Responders in Melanoma Immunotherapy?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6039280

26 August 2018

MEK inhibitor-associated retinopathy (MEKAR) in metastatic melanoma: Long-term ophthalmic effects.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6039280

26 August 2018

Cobimetinib combined with vemurafenib in advanced BRAF(V600)-mutant melanoma (coBRIM): updated efficacy results from a randomised, double-blind, phase 3 trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6039280

26 August 2018

Risk of Ophthalmic Adverse Effects in Patients Treated with MEK Inhibitors: A Systematic Review and Meta-Analysis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6039280

26 August 2018

Methods for Studying Autophagy Within the Tumor Microenvironment

1 reference

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26 August 2018

Subretinal Fluid Associated With MEK Inhibitor Use in the Treatment of Systemic Cancer

1 reference

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26 August 2018

Retinal Toxicity Associated With MEK Inhibitor Use for Metastatic Cancer: A Rising Trend in Ophthalmology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6039280

26 August 2018

Loss of MAPK Pathway Activation in Post-Mitotic Retinal Cells as Mechanism in MEK Inhibition-Related Retinopathy in Cancer Patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6039280

26 August 2018

Separation of outer retinal layers secondary to selumetinib

1 reference

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26 August 2018

The state of melanoma: challenges and opportunities

1 reference

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26 August 2018

Detailed functional and structural phenotype of Bietti crystalline dystrophy associated with mutations in CYP4V2 complicated by choroidal neovascularization.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6039280

26 August 2018

Recommendations on Screening for Chloroquine and Hydroxychloroquine Retinopathy (2016 Revision).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6039280

26 August 2018

Ocular toxicities of MEK inhibitors and other targeted therapies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6039280

26 August 2018

Long-Term Evaluation of MEK Inhibitor Retinal Toxicity With Multimodal Imaging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6039280

26 August 2018

Survival of patients with advanced metastatic melanoma: The impact of novel therapies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6039280

26 August 2018

Retinal toxicity of high-dose hydroxychloroquine in patients with chronic graft-versus-host disease

1 reference

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26 August 2018

Photoreceptor phagosome processing defects and disturbed autophagy in retinal pigment epithelium of Cln3Δex1-6 mice modelling juvenile neuronal ceroid lipofuscinosis (Batten disease).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6039280

26 August 2018

Ocular Toxicity in Metastatic Melanoma Patients Treated With Mitogen-Activated Protein Kinase Kinase Inhibitors: A Case Series.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6039280

26 August 2018

Serous Retinopathy Associated with Mitogen-Activated Protein Kinase Kinase Inhibition (Binimetinib) for Metastatic Cutaneous and Uveal Melanoma

1 reference

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26 August 2018

Reflectivity of the outer retina on spectral-domain optical coherence tomography as a predictor of photoreceptor cone density.

1 reference

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26 August 2018

Severe bilateral panuveitis during melanoma treatment by Dabrafenib and Trametinib

1 reference

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26 August 2018

A comparison of some organizational characteristics of the mouse central retina and the human macula

1 reference

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26 August 2018

Management of BRAF and MEK inhibitor toxicities in patients with metastatic melanoma

1 reference

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26 August 2018

Untangling autophagy measurements: all fluxed up.

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26 August 2018

Improved overall survival in melanoma with combined dabrafenib and trametinib

1 reference

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26 August 2018

The cellular origins of the outer retinal bands in optical coherence tomography images

1 reference

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26 August 2018

Combined vemurafenib and cobimetinib in BRAF-mutated melanoma

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26 August 2018

Combined BRAF and MEK inhibition versus BRAF inhibition alone in melanoma

1 reference

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26 August 2018

Ocular toxicity in BRAF mutant cutaneous melanoma patients treated with vemurafenib

1 reference

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26 August 2018

Retinal toxicities of cancer therapy drugs: biologics, small molecule inhibitors, and chemotherapies.

1 reference

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26 August 2018

Transient MEK inhibitor-associated retinopathy in metastatic melanoma.

1 reference

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26 August 2018

Relationship between foveal cone specialization and pit morphology in albinism

1 reference

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26 August 2018

Prospects for MEK inhibitors for treating cancer.

1 reference

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26 August 2018

Targeting ER stress-induced autophagy overcomes BRAF inhibitor resistance in melanoma.

1 reference

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26 August 2018

BRAF inhibitor resistance mechanisms in metastatic melanoma: spectrum and clinical impact.

1 reference

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26 August 2018

Ocular adverse events of molecularly targeted agents approved in solid tumours: a systematic review

1 reference

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26 August 2018

Human cone visual pigment deletions spare sufficient photoreceptors to warrant gene therapy

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26 August 2018

Multimodal assessment of microscopic morphology and retinal function in patients with geographic atrophy.

1 reference

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26 August 2018

Bilateral Multifocal Central Serous-Like Chorioretinopathy due to MEK Inhibition for Metastatic Cutaneous Melanoma

1 reference

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26 August 2018

Effect of inhibition of the FGFR-MAPK signaling pathway on the development of ocular toxicities

1 reference

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26 August 2018

Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations

1 reference

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26 August 2018

Safety, pharmacokinetic, pharmacodynamic, and efficacy data for the oral MEK inhibitor trametinib: a phase 1 dose-escalation trial

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26 August 2018

Phase I dose-escalation study of the safety, pharmacokinetics, and pharmacodynamics of the MEK inhibitor RO4987655 (CH4987655) in patients with advanced solid tumors.

1 reference

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26 August 2018

Improved survival with MEK inhibition in BRAF-mutated melanoma

1 reference

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26 August 2018

Ocular toxicity of targeted therapies

1 reference

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26 August 2018

Acquired resistance to BRAF inhibition can confer cross-resistance to combined BRAF/MEK inhibition.

1 reference

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26 August 2018

The role of autophagy in cancer: therapeutic implications

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26 August 2018

Anatomical correlates to the bands seen in the outer retina by optical coherence tomography: literature review and model

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26 August 2018

Defective photoreceptor phagocytosis in a mouse model of enhanced S-cone syndrome causes progressive retinal degeneration

1 reference

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26 August 2018

Imaging outer segment renewal in living human cone photoreceptors.

1 reference

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26 August 2018

MEK/ERK pathway mediates UVB-induced AQP1 downregulation and water permeability impairment in human retinal pigment epithelial cells

1 reference

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26 August 2018

High-speed volumetric imaging of cone photoreceptors with adaptive optics spectral-domain optical coherence tomography.

1 reference

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26 August 2018

Measuring retinal contributions to the optical Stiles-Crawford effect with optical coherence tomography

1 reference

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26 August 2018

Retinal laminar architecture in human retinitis pigmentosa caused by Rhodopsin gene mutations

1 reference

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26 August 2018

Characterization of outer retinal morphology with high-speed, ultrahigh-resolution optical coherence tomography

1 reference

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26 August 2018

The roles of therapy-induced autophagy and necrosis in cancer treatment

1 reference

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26 August 2018

Elongation of photoreceptor outer segment in central serous chorioretinopathy

1 reference

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26 August 2018

Mutations of the BRAF gene in human cancer

1 reference

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26 August 2018

The phagocytosis of rod outer segments is inhibited by selected drugs in retinal pigment epithelial cell cultures

1 reference

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26 August 2018

Mitogen-activated protein and tyrosine kinases in the activation of astrocyte volume-activated chloride current.

1 reference

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26 August 2018

Mammalian cones: disc shedding, phagocytosis, and renewal

1 reference

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26 August 2018

Cutaneous melanoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6039280

2 November 2018

Bilateral Subfoveal Neurosensory Retinal Detachment Associated With MEK Inhibitor Use for Metastatic Cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6039280

30 November 2018

Retinal dystrophy in the rat--a pigment epithelial disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/29324592

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relation of optical coherence tomography to microanatomy in normal and rd chickens

1 reference

https://pubmed.ncbi.nlm.nih.gov/29324592

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Three-dimensional Imaging of the Foveal Photoreceptor Layer in Central Serous Chorioretinopathy Using High-speed Optical Coherence Tomography

1 reference

https://pubmed.ncbi.nlm.nih.gov/29324592

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fundus autofluorescence of elongated photoreceptor outer segments in central serous chorioretinopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29324592

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The functional significance of foveal abnormalities in albinism measured using spectral-domain optical coherence tomography

1 reference

https://pubmed.ncbi.nlm.nih.gov/29324592

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The inner segment/outer segment border seen on optical coherence tomography is less intense in patients with diminished cone function

1 reference

https://pubmed.ncbi.nlm.nih.gov/29324592

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MEK inhibitors: a new class of chemotherapeutic agents with ocular toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/29324592

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MEK inhibitors and their potential in the treatment of advanced melanoma: the advantages of combination therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/29324592

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydroxychloroquine Screening Alert: Change is in the Wind

1 reference

https://pubmed.ncbi.nlm.nih.gov/29324592

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Strategies for Overcoming Resistance in Tumours Harboring BRAF Mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/29324592

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of Retinal Fluid Accumulation and Blood-Retinal Barrier Breakdown.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29324592

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Retinopatía MEK. Casos clínicos

1 reference

https://pubmed.ncbi.nlm.nih.gov/29324592

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ACUTE EXUDATIVE PARANEOPLASTIC POLYMORPHOUS VITELLIFORM MACULOPATHY DURING VEMURAFENIB AND PEMBROLIZUMAB TREATMENT FOR METASTATIC MELANOMA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/29324592

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1097/IAE.0000000000002027

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29324592%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29324592%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29324592%20AND%20SRC:MED&resulttype=core&format=json

4 June 2020

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