(Q50125551)

25 February 2018

title

CTLA-4, an Essential Immune-Checkpoint for T-Cell Activation. (English)

1 reference

25 February 2018

author name string

Shunsuke Chikuma

series ordinal

1

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25 February 2018

publication date

13 September 2017

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25 February 2018

Current Topics in Microbiology and Immunology

published in

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25 February 2018

volume

410

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25 February 2018

page(s)

99-126

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25 February 2018

Toll-like receptors: critical proteins linking innate and acquired immunity

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1 reference

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Genetic evidence that the differential expression of the ligand-independent isoform of CTLA-4 is the molecular basis of the Idd5.1 type 1 diabetes region in nonobese diabetic mice.

21 January 2018

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Dendritic cells and the control of immunity

21 January 2018

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Inhibition of CTLA-4 function by the regulatory subunit of serine/threonine phosphatase 2A

21 January 2018

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https://api.crossref.org/works/10.1007%2F82_2017_61

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL.

21 January 2018

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https://api.crossref.org/works/10.1007%2F82_2017_61

Intrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28/ B7 family

21 January 2018

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https://api.crossref.org/works/10.1007%2F82_2017_61

CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment

21 January 2018

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https://api.crossref.org/works/10.1007%2F82_2017_61

Somatic mutations and immunotherapy outcome with CTLA-4 blockade in melanoma

21 January 2018

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Interaction of the cytoplasmic tail of CTLA-4 (CD152) with a clathrin-associated protein is negatively regulated by tyrosine phosphorylation

21 January 2018

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https://api.crossref.org/works/10.1007%2F82_2017_61

A new member of the immunoglobulin superfamily--CTLA-4

21 January 2018

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https://api.crossref.org/works/10.1007%2F82_2017_61

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

21 January 2018

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https://api.crossref.org/works/10.1007%2F82_2017_61

Cytotoxic T lymphocyte antigen 4 (CTLA-4) interferes with extracellular signal-regulated kinase (ERK) and Jun NH2-terminal kinase (JNK) activation, but does not affect phosphorylation of T cell receptor zeta and ZAP70.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Thymocyte development is normal in CTLA-4-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates primary and secondary peptide-specific CD4(+) T cell responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Lymphoproliferation in CTLA-4-deficient mice is mediated by costimulation-dependent activation of CD4+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4

21 January 2018

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https://api.crossref.org/works/10.1007%2F82_2017_61

Basics of PD-1 in self-tolerance, infection, and cancer immunity

21 January 2018

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https://api.crossref.org/works/10.1007%2F82_2017_61

B7-independent inhibition of T cells by CTLA-4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Expression of CTLA-4 and FOXP3 in cis protects from lethal lymphoproliferative disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Negative regulation of T cell receptor-lipid raft interaction by cytotoxic T lymphocyte-associated antigen 4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

PD-1-mediated suppression of IL-2 production induces CD8+ T cell anergy in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

The CD28 and CTLA-4 receptors associate with the serine/threonine phosphatase PP2A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Immunogenic (tum-) variants of mouse tumor P815: cloning of the gene of tum- antigen P91A and identification of the tum- mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

CTLA-4 gene polymorphism is associated with predisposition to coeliac disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Induction of cytotoxic T lymphocyte antigen 4 (CTLA-4) restricts clonal expansion of helper T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Modulation of tryptophan catabolism by regulatory T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Induction of T cell anergy in the absence of CTLA-4/B7 interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

CTLA-4 is not required for induction of CD8(+) T cell anergy in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

The CD28 signaling pathway regulates glucose metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Protein kinase C η is required for T cell activation and homeostatic proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Absence of CTLA-4 lowers the activation threshold of primed CD8+ TCR-transgenic T cells: lack of correlation with Src homology domain 2-containing protein tyrosine phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

CTLA4 gene polymorphism and autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Blockade of T cell activation using a surface-linked single-chain antibody to CTLA-4 (CD152).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Lack of intrinsic CTLA-4 expression has minimal effect on regulation of antiviral T-cell immunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Control of regulatory T cell development by the transcription factor Foxp3

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

T-cell invigoration to tumour burden ratio associated with anti-PD-1 response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Brief report: increased expression of a short splice variant of CTLA-4 exacerbates lupus in MRL/lpr mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

CTLA-4 suppresses the pathogenicity of self antigen-specific T cells by cell-intrinsic and cell-extrinsic mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Dual function of CTLA-4 in regulatory T cells and conventional T cells to prevent multiorgan autoimmunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

An essential role for Scurfin in CD4+CD25+ T regulatory cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Protein kinase C-η controls CTLA-4-mediated regulatory T cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Manipulation of T cell costimulatory and inhibitory signals for immunotherapy of prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Enhancement of antitumor immunity by CTLA-4 blockade

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Molecular basis of T cell inactivation by CTLA-4

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Cytotoxic T lymphocyte-associated molecule-4, a high-avidity receptor for CD80 and CD86, contains an intracellular localization motif in its cytoplasmic tail

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

The CTLA-4 gene is associated with multiple sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Complete sequence determination of the mouse and human CTLA4 gene loci: cross-species DNA sequence similarity beyond exon borders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Binding stoichiometry of the cytotoxic T lymphocyte-associated molecule-4 (CTLA-4). A disulfide-linked homodimer binds two CD86 molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Overexpression of the Ctla-4 isoform lacking exons 2 and 3 causes autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Patients with LRBA deficiency show CTLA4 loss and immune dysregulation responsive to abatacept therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

SHP-1 and SHP-2 in T cells: two phosphatases functioning at many levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Structure of the gene of tum- transplantation antigen P91A: the mutated exon encodes a peptide recognized with Ld by cytolytic T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

A soluble form of CTLA-4 generated by alternative splicing is expressed by nonstimulated human T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

B7-dependent T-cell costimulation in mice lacking CD28 and CTLA4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Structural analysis of CTLA-4 function in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Neonates support lymphopenia-induced proliferation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Src family tyrosine kinases associate with and phosphorylate CTLA-4 (CD152).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Cytotoxic T lymphocyte antigen 4 (CTLA-4) engagement delivers an inhibitory signal through the membrane-proximal region in the absence of the tyrosine motif in the cytoplasmic tail

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

A native soluble form of CTLA-4

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Structure of murine CTLA-4 and its role in modulating T cell responsiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Complementarity determining region 1 (CDR1)- and CDR3-analogous regions in CTLA-4 and CD28 determine the binding to B7-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

B7-1 and B7-2 selectively recruit CTLA-4 and CD28 to the immunological synapse

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

IDO and regulatory T cells: a role for reverse signalling and non-canonical NF-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Trans-endocytosis of CD80 and CD86: a molecular basis for the cell-extrinsic function of CTLA-4

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Ipilimumab plus dacarbazine for previously untreated metastatic melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

CTLA-4: a key regulatory point in the control of autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Tyrosine phosphatase SHP-2 binding to CTLA-4: absence of direct YVKM/YFIP motif recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Resting lymphocyte kinase (Rlk/Txk) phosphorylates the YVKM motif and regulates PI 3-kinase binding to T-cell antigen CTLA-4

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Structural basis for co-stimulation by the human CTLA-4/B7-2 complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Basis of CTLA-4 function in regulatory and conventional CD4(+) T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

In vivo overexpression of CTLA-4 suppresses lymphoproliferative diseases and thymic negative selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Distinct roles of CTLA-4 and TGF-beta in CD4+CD25+ regulatory T cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Cutting Edge: CD28 Controls Peripheral Homeostasis of CD4+CD25+ Regulatory T Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) and granulocyte/macrophage colony-stimulating factor (GM-CSF)-producing vaccines induces rejection of subcutaneous and metastatic tumors accomp

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

CTLA-4 can function as a negative regulator of T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Cutting edge: cell-extrinsic immune regulation by CTLA-4 expressed on conventional T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

CTLA-4 control over Foxp3+ regulatory T cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Nivolumab plus ipilimumab in advanced melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

FOXP3 controls regulatory T cell function through cooperation with NFAT

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Docking protein Gab2 is phosphorylated by ZAP-70 and negatively regulates T cell receptor signaling by recruitment of inhibitory molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Immune tolerance. Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Tyrosine-mediated inhibitory signals contribute to CTLA-4 function in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Endogenous antigen tunes the responsiveness of naive B cells but not T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Normal pathogen-specific immune responses mounted by CTLA-4-deficient T cells: a paradigm reconsidered

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

CTLA-4 gene polymorphisms in systemic lupus erythematosus: a highly significant association with a determinant in the promoter region

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

CD25(+)CD4(+) regulatory T cells exert in vitro suppressive activity independent of CTLA-4

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Cytotoxic T lymphocyte antigen 4 (CTLA-4) inhibits CD28-induced IkappaBalpha degradation and RelA activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Normal thymic selection, normal viability and decreased lymphoproliferation in T cell receptor-transgenic CTLA-4-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Spatiotemporal basis of CTLA-4 costimulatory molecule-mediated negative regulation of T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2F82_2017_61

21 January 2018

Identifiers

DOI

10.1007/82_2017_61

1 reference

25 February 2018

PubMed ID

28900679

1 reference

25 February 2018