(Q50530099)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21190426%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

title

Some sulfonamide drugs inhibit ATPase activity of heat shock protein 90: investigation by docking simulation and experimental validation (English)

1 reference

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18 January 2020

3

1 reference

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18 January 2020

Mahmoud A Al-Sha'er

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21190426%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

author name string

Ghassan Abu Sheikha

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21190426%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

publication date

29 December 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21190426%20AND%20SRC:MED&resulttype=core&format=json

Journal of Enzyme Inhibition and Medicinal Chemistry

18 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21190426%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

volume

26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21190426%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

issue

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21190426%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

page(s)

603-609

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21190426%20AND%20SRC:MED&resulttype=core&format=json

Targeting HSP90 for cancer therapy

18 January 2020

cites work

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Heat shock protein 90 as a molecular target for cancer therapeutics

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Altered states: selectively drugging the Hsp90 cancer chaperone

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Heat shock protein 90 inhibitors. A text book example of medicinal chemistry?

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Therapeutic and diagnostic implications of Hsp90 activation

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Heat-shock protein 90 inhibitors as novel cancer chemotherapeutics - an update

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Targeting of multiple signalling pathways by heat shock protein 90 molecular chaperone inhibitors

21 January 2018

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Targeting the molecular chaperone heat shock protein 90 provides a multifaceted effect on diverse cell signaling pathways of cancer cells

21 January 2018

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Drugging the cancer chaperone HSP90: combinatorial therapeutic exploitation of oncogene addiction and tumor stress

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The Hsp90 molecular chaperone: an open and shut case for treatment

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HSP90 as a new therapeutic target for cancer therapy: the story unfolds

21 January 2018

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The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin

21 January 2018

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Phase I pharmacokinetic and pharmacodynamic study of 17-allylamino, 17-demethoxygeldanamycin in patients with advanced malignancies

21 January 2018

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Combination of trastuzumab and tanespimycin (17-AAG, KOS-953) is safe and active in trastuzumab-refractory HER-2 overexpressing breast cancer: a phase I dose-escalation study

21 January 2018

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DT-Diaphorase expression and tumor cell sensitivity to 17-allylamino, 17-demethoxygeldanamycin, an inhibitor of heat shock protein 90

21 January 2018

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Antiangiogenic properties of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin: an orally bioavailable heat shock protein 90 modulator

21 January 2018

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Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90.

21 January 2018

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Development of 17-allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride (IPI-504), an anti-cancer agent directed against Hsp90.

21 January 2018

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Geldanamycin as a potential anti-cancer agent: its molecular target and biochemical activity

21 January 2018

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Development of Radicicol Analogues

21 January 2018

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Discovery and development of pyrazole-scaffold Hsp90 inhibitors

21 January 2018

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Targeting Hsp90: small-molecule inhibitors and their clinical development

21 January 2018

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Recent advances in Hsp90 inhibitors as antitumor agents

21 January 2018

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Heat shock protein 90: inhibitors in clinical trials.

21 January 2018

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Synthesis and SAR study of N-(4-hydroxy-3-(2-hydroxynaphthalene-1-yl)phenyl)-arylsulfonamides: heat shock protein 90 (Hsp90) inhibitors with submicromolar activity in an in vitro assay

21 January 2018

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Structure-based discovery of a new class of Hsp90 inhibitors

21 January 2018

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Cytotoxic sulphonamides designed for selective deposition in malignant tissue

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An improved assay for nanomole amounts of inorganic phosphate

21 January 2018

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Development and optimization of a useful assay for determining Hsp90's inherent ATPase activity

21 January 2018

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LigandFit: a novel method for the shape-directed rapid docking of ligands to protein active sites

21 January 2018

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The development of a simple empirical scoring function to estimate the binding constant for a protein-ligand complex of known three-dimensional structure

21 January 2018

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A general and fast scoring function for protein-ligand interactions: a simplified potential approach.

21 January 2018

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Prediction of binding constants of protein ligands: a fast method for the prioritization of hits obtained from de novo design or 3D database search programs

21 January 2018

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High-throughput screening assay for inhibitors of heat-shock protein 90 ATPase activity

21 January 2018

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Assays for identification of Hsp90 inhibitors and biochemical methods for discriminating their mechanism of action

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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