(Q50648148)

English

New BRAF knockin mice provide a pathogenetic mechanism of developmental defects and a therapeutic approach in cardio-facio-cutaneous syndrome.

scientific article published on 17 July 2014

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

17 March 2018

http://europepmc.org/abstract/MED/25035421

New BRAF knockin mice provide a pathogenetic mechanism of developmental defects and a therapeutic approach in cardio-facio-cutaneous syndrome. (English)

1 reference

Europe PubMed Central

PubMed publication ID

17 March 2018

http://europepmc.org/abstract/MED/25035421

author name string

Shin-Ichi Inoue

1

1 reference

Europe PubMed Central

PubMed publication ID

17 March 2018

http://europepmc.org/abstract/MED/25035421

Mitsuji Moriya

2

1 reference

Europe PubMed Central

PubMed publication ID

17 March 2018

http://europepmc.org/abstract/MED/25035421

Yusuke Watanabe

3

1 reference

Europe PubMed Central

PubMed publication ID

17 March 2018

http://europepmc.org/abstract/MED/25035421

Sachiko Miyagawa-Tomita

4

1 reference

Europe PubMed Central

PubMed publication ID

17 March 2018

http://europepmc.org/abstract/MED/25035421

Tetsuya Niihori

5

1 reference

Europe PubMed Central

PubMed publication ID

17 March 2018

http://europepmc.org/abstract/MED/25035421

Daiju Oba

6

1 reference

Europe PubMed Central

PubMed publication ID

17 March 2018

http://europepmc.org/abstract/MED/25035421

Masao Ono

7

1 reference

Europe PubMed Central

PubMed publication ID

17 March 2018

http://europepmc.org/abstract/MED/25035421

Shigeo Kure

8

1 reference

Europe PubMed Central

PubMed publication ID

17 March 2018

http://europepmc.org/abstract/MED/25035421

Toshihiko Ogura

9

1 reference

Europe PubMed Central

PubMed publication ID

17 March 2018

http://europepmc.org/abstract/MED/25035421

Yoichi Matsubara

10

1 reference

Europe PubMed Central

PubMed publication ID

17 March 2018

http://europepmc.org/abstract/MED/25035421

Yoko Aoki

11

1 reference

Europe PubMed Central

PubMed publication ID

17 March 2018

http://europepmc.org/abstract/MED/25035421

publication date

17 July 2014

1 reference

Europe PubMed Central

PubMed publication ID

17 March 2018

http://europepmc.org/abstract/MED/25035421

Human Molecular Genetics

1 reference

Europe PubMed Central

PubMed publication ID

17 March 2018

http://europepmc.org/abstract/MED/25035421

23

1 reference

Europe PubMed Central

PubMed publication ID

17 March 2018

http://europepmc.org/abstract/MED/25035421

24

1 reference

Europe PubMed Central

PubMed publication ID

17 March 2018

http://europepmc.org/abstract/MED/25035421

6553-6566

1 reference

Europe PubMed Central

PubMed publication ID

17 March 2018

http://europepmc.org/abstract/MED/25035421

New multiple congenital anomalies/mental retardation syndrome with cardio-facio-cutaneous involvement--the CFC syndrome

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU376

21 January 2018

Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU376

21 January 2018

Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU376

21 January 2018

Molecular and clinical characterization of cardio-facio-cutaneous (CFC) syndrome: overlapping clinical manifestations with Costello syndrome.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU376

21 January 2018

RAS oncogenes: the first 30 years.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU376

21 January 2018

Gain-of-function mutations in RIT1 cause Noonan syndrome, a RAS/MAPK pathway syndrome

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU376

21 January 2018

The RAS/MAPK syndromes: novel roles of the RAS pathway in human genetic disorders

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU376

21 January 2018

The RASopathies: developmental syndromes of Ras/MAPK pathway dysregulation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU376

21 January 2018

Mutations of the BRAF gene in human cancer

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU376

21 January 2018

The intermediate-activity (L597V)BRAF mutant acts as an epistatic modifier of oncogenic RAS by enhancing signaling through the RAF/MEK/ERK pathway

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU376

21 January 2018

Germline BRAF mutations in Noonan, LEOPARD, and cardiofaciocutaneous syndromes: molecular diversity and associated phenotypic spectrum

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU376

21 January 2018

Overlapping and specific functions of Braf and Craf-1 proto-oncogenes during mouse embryogenesis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU376

21 January 2018

Endothelial apoptosis in Braf-deficient mice

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU376

21 January 2018

Expression of endogenous oncogenic V600EB-raf induces proliferation and developmental defects in mice and transformation of primary fibroblasts

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU376

21 January 2018

Constitutive activation of B-Raf in the mouse germ line provides a model for human cardio-facio-cutaneous syndrome

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU376

21 January 2018

Role of mesodermal FGF8 and FGF10 overlaps in the development of the arterial pole of the heart and pharyngeal arch arteries

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU376

21 January 2018

Identification of direct transcriptional targets of (V600E)BRAF/MEK signalling in melanoma

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU376

21 January 2018

Endothelial ERK signaling controls lymphatic fate specification

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU376

21 January 2018

Molecular mechanisms of lymphatic vascular development

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU376

21 January 2018

Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome–associated Sos1 mutation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU376

21 January 2018

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU376

21 January 2018

UTX, a histone H3-lysine 27 demethylase, acts as a critical switch to activate the cardiac developmental program

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU376

21 January 2018

X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex-specific manner

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU376

21 January 2018

De novo mutations in histone-modifying genes in congenital heart disease.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU376

21 January 2018

Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU376

21 January 2018

Prenatal diagnostic testing of the Noonan syndrome genes in fetuses with abnormal ultrasound findings.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU376

21 January 2018

Prenatal features of Noonan syndrome

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU376

21 January 2018

Noonan syndrome: clinical features, diagnosis, and management guidelines

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU376

21 January 2018

Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome-associated PTPN11 mutation.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU376

21 January 2018

MEK-ERK pathway modulation ameliorates disease phenotypes in a mouse model of Noonan syndrome associated with the Raf1(L613V) mutation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU376

21 January 2018

Polycomb repressive complex 2 regulates normal development of the mouse heart

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU376

21 January 2018

Deletion of KDM6A, a histone demethylase interacting with MLL2, in three patients with Kabuki syndrome

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU376

21 January 2018

Histone H3 lysine 9 methyltransferases, G9a and GLP are essential for cardiac morphogenesis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU376

21 January 2018

A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU376

21 January 2018

The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU376

21 January 2018

MEK-ERK pathway regulates EZH2 overexpression in association with aggressive breast cancer subtypes

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU376

21 January 2018

Role of ERK1/2 signaling in congenital valve malformations in Noonan syndrome

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU376

21 January 2018

Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU376

21 January 2018

Effects of germline mutations in the Ras/MAPK signaling pathway on adaptive behavior: cardiofaciocutaneous syndrome and Noonan syndrome.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU376

21 January 2018

Bone resorption in syndromes of the Ras/MAPK pathway

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU376

21 January 2018

Further delineation of cardio-facio-cutaneous syndrome: clinical features of 38 individuals with proven mutations.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU376

21 January 2018

Lineage-specific cell disruption in living mice by Cre-mediated expression of diphtheria toxin A chain.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU376

21 January 2018

Efficient selection for high-expression transfectants with a novel eukaryotic vector

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDU376

21 January 2018

Identifiers

10.1093/HMG/DDU376

1 reference

Europe PubMed Central

PubMed publication ID

17 March 2018

http://europepmc.org/abstract/MED/25035421

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

17 March 2018

http://europepmc.org/abstract/MED/25035421

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q50648148&oldid=1704429609"