(Q50861765)

English

In vivo activation of Wnt signaling pathway enhances cognitive function of adult mice and reverses cognitive deficits in an Alzheimer's disease model.

scientific article published in February 2014

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scholarly article

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7 March 2020

In vivo activation of Wnt signaling pathway enhances cognitive function of adult mice and reverses cognitive deficits in an Alzheimer's disease model (English)

1 reference

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7 March 2020

Alzheimer's disease

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inferred from title

author name string

Jessica Y Vargas

1

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7 March 2020

Marco Fuenzalida

2

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7 March 2020

Nibaldo C Inestrosa

3

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7 March 2020

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1 February 2014

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7 March 2020

Journal of Neuroscience

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7 March 2020

34

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7 March 2020

6

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7 March 2020

2191-2202

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7 March 2020

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6608527/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Does dysregulation of the Notch and wingless/Wnt pathways underlie the pathogenesis of Alzheimer's disease?

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Axonal remodeling and synaptic differentiation in the cerebellum is regulated by WNT-7a signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

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Wnt signaling function in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

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A learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

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Alzheimer's disease results from the cerebral accumulation and cytotoxicity of amyloid beta-protein

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https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

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Protein kinase C inhibits amyloid beta peptide neurotoxicity by acting on members of the Wnt pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

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Alzheimer's disease is a synaptic failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by beta-amyloid fibrils

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

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Members of the Wnt, Fz, and Frp gene families expressed in postnatal mouse cerebral cortex

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

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Progressive age-related development of Alzheimer-like pathology in APP/PS1 mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt-3a overcomes beta-amyloid toxicity in rat hippocampal neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

WNT and beta-catenin signalling: diseases and therapies

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Translational regulatory mechanisms in persistent forms of synaptic plasticity

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired long-term potentiation in c-Jun N-terminal kinase 2-deficient mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

WNTs in the vertebrate nervous system: from patterning to neuronal connectivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spatial segregation of neuronal calcium signals encodes different forms of LTP in rat hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A formylated hexapeptide ligand mimics the ability of Wnt-5a to impair migration of human breast epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activity-dependent synaptic Wnt release regulates hippocampal long term potentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aging-dependent alterations in synaptic plasticity and memory in mice that overexpress extracellular superoxide dismutase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of cellular prion protein on LTP expression in aged mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

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Signaling across the synapse: a role for Wnt and Dishevelled in presynaptic assembly and neurotransmitter release

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dvl regulates endo- and exocytotic processes through binding to synaptotagmin

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

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Glycogen synthase kinase-3 inhibition is integral to long-term potentiation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

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LTP forms 1, 2 and 3: different mechanisms for the "long" in long-term potentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LTP inhibits LTD in the hippocampus via regulation of GSK3beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

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Object recognition in rats and mice: a one-trial non-matching-to-sample learning task to study 'recognition memory'.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt-7a induces presynaptic colocalization of alpha 7-nicotinic acetylcholine receptors and adenomatous polyposis coli in hippocampal neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Common genetic variation within the low-density lipoprotein receptor-related protein 6 and late-onset Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for an enhancement of excitatory transmission in adult CNS by Wnt signaling pathway modulation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synaptic plasticity: multiple forms, functions, and mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt-7a modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid-beta binds to the extracellular cysteine-rich domain of Frizzled and inhibits Wnt/beta-catenin signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spine dynamics and synapse remodeling during LTP and memory processes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-catenin is required for memory consolidation

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Wnt-5a-derived hexapeptide Foxy-5 inhibits breast cancer metastasis in vivo by targeting cell motility

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt signaling in Alzheimer's disease: up or down, that is the question

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

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Making synaptic plasticity and memory last: mechanisms of translational regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt-5a/JNK signaling promotes the clustering of PSD-95 in hippocampal neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt signaling mediates experience-related regulation of synapse numbers and mossy fiber connectivities in the adult hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of Wnt signaling by lithium and rosiglitazone reduced spatial memory impairment and neurodegeneration in brains of an APPswe/PSEN1DeltaE9 mouse model of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt signaling modulates pre- and postsynaptic maturation: therapeutic considerations.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium/calmodulin-dependent protein kinase type IV is a target gene of the Wnt/beta-catenin signaling pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Towards an integrated view of Wnt signaling in development

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Emerging roles of Wnts in the adult nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of Wnt signaling in neuroprotection

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt-5a occludes Abeta oligomer-induced depression of glutamatergic transmission in hippocampal neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt-5a modulates recycling of functional GABAA receptors on hippocampal neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Generation and therapeutic efficacy of highly oligomer-specific beta-amyloid antibodies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toll-like receptor 3 inhibits memory retention and constrains adult hippocampal neurogenesis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wingless-type family member 5A (Wnt-5a) stimulates synaptic differentiation and function of glutamatergic synapses.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt signaling pathway overcomes the disruption of neuronal differentiation of neural progenitor cells induced by oligomeric amyloid β-peptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt signaling during synaptic development and plasticity

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutamate released spontaneously from astrocytes sets the threshold for synaptic plasticity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt7a signaling promotes dendritic spine growth and synaptic strength through Ca²⁺/Calmodulin-dependent protein kinase II

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of NMDA-receptor synaptic transmission by Wnt signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt signaling in amygdala-dependent learning and memory

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of GSK3β improves hippocampus-dependent learning and rescues neurogenesis in a mouse model of fragile X syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt transmembrane signaling and long-term spatial memory

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt-5a is a synaptogenic factor with neuroprotective properties against Aβ toxicity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adenomatous polyposis coli heterozygous knockout mice display hypoactivity and age-dependent working memory deficits

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The secreted Wnt antagonist Dickkopf-1 is required for amyloid β-mediated synaptic loss.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synapses and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

WNTs in synapse formation and neuronal circuitry

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Three decades of Wnts: a personal perspective on how a scientific field developed

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

c-Jun N-terminal phosphorylation is essential for hippocampal synaptic plasticity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt signaling: role in Alzheimer disease and schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycogen synthase kinase-3 inhibition prevents learning deficits in diabetic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt signaling: role in LTP, neural networks and memory

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

WNT signaling in neuronal maturation and synaptogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Canonical Wnt signaling is necessary for object recognition memory consolidation

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term potentiation phenomena in the rat limbic forebrain

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of excitatory circuitry in the hippocampus

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24501359

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.0862-13.2014

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24501359%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24501359%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24501359%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

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