(Q50864373)

http://europepmc.org/abstract/MED/28255011

24 March 2018

title

Ranolazine Prevents Phenotype Development in a Mouse Model of Hypertrophic Cardiomyopathy (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6284403&resulttype=core&format=json

13 May 2020

1 reference

10

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14 June 2020

Elisabetta Cerbai

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28255011%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

Claudia Crocini

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28255011%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

Leonardo Sacconi

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28255011%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

Annunziatina Laurino

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28255011%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

author name string

Raffaele Coppini

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28255011%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

Luca Mazzoni

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28255011%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

Cecilia Ferrantini

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28255011%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

Francesca Gentile

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28255011%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

Josè Manuel Pioner

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28255011%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

Lorenzo Santini

7

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14 June 2020

Valentina Bargelli

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28255011%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

Matteo Rotellini

9

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28255011%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

Chiara Tesi

13

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28255011%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

Luiz Belardinelli

14

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28255011%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

Jil Tardiff

15

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28255011%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

Alessandro Mugelli

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28255011%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

Iacopo Olivotto

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28255011%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

Corrado Poggesi

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28255011%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

publication date

1 March 2017

1 reference

http://europepmc.org/abstract/MED/28255011

24 March 2018

published in

Circulation: Heart Failure

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28255011%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

volume

10

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14 June 2020

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28255011%20AND%20SRC:MED&resulttype=core&format=json

Familial hypertrophic cardiomyopathy-linked mutant troponin T causes stress-induced ventricular tachycardia and Ca2+-dependent action potential remodeling.

14 June 2020

cites work

1 reference

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Neonatal gene transfer of Serca2a delays onset of hypertrophic remodeling and improves function in familial hypertrophic cardiomyopathy

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Hypertrophy, fibrosis, and sudden cardiac death in response to pathological stimuli in mice with mutations in cardiac troponin T.

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Myofilament Ca sensitization increases cytosolic Ca binding affinity, alters intracellular Ca homeostasis, and causes pause-dependent Ca-triggered arrhythmia.

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Independent FHC-related cardiac troponin T mutations exhibit specific alterations in myocellular contractility and calcium kinetics

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Antiadrenergic and hemodynamic effects of ranolazine in conscious dogs

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Quantification of cardiomyocyte hypertrophy by cardiac magnetic resonance: implications for early cardiac remodeling

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The L-type calcium channel inhibitor diltiazem prevents cardiomyopathy in a mouse model

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12 December 2020

Increased myofilament Ca2+ sensitivity and diastolic dysfunction as early consequences of Mybpc3 mutation in heterozygous knock-in mice

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Late sodium current inhibition reverses electromechanical dysfunction in human hypertrophic cardiomyopathy

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12 December 2020

Novel Approach Targeting the Complex Pathophysiology of Hypertrophic Cardiomyopathy: The Impact of Late Sodium Current Inhibition on Exercise Capacity in Subjects with Symptomatic Hypertrophic Cardiomyopathy (LIBERTY-HCM) Trial

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Developmental origins of hypertrophic cardiomyopathy phenotypes: a unifying hypothesis.

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Myofilament protein gene mutation screening and outcome of patients with hypertrophic cardiomyopathy

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12 December 2020

Ranolazine antagonizes catecholamine-induced dysfunction in isolated cardiomyocytes, but lacks long-term therapeutic effects in vivo in a mouse model of hypertrophic cardiomyopathy.

1 reference

12 December 2020

CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy

1 reference

12 December 2020

Voltage-Gated Sodium Channel Phosphorylation at Ser571 Regulates Late Current, Arrhythmia, and Cardiac Function In Vivo

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12 December 2020

UDP-glucose enhances outward K(+) currents necessary for cell differentiation and stimulates cell migration by activating the GPR17 receptor in oligodendrocyte precursors

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12 December 2020

Assessment and Significance of Left Ventricular Mass by Cardiovascular Magnetic Resonance in Hypertrophic Cardiomyopathy

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12 December 2020

Aldosterone, through novel signaling proteins, is a fundamental molecular bridge between the genetic defect and the cardiac phenotype of hypertrophic cardiomyopathy

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12 December 2020

Transmitral inflow pattern assessed by Doppler echocardiography in angiotensin II type 1A receptor knockout mice with myocardial infarction.

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12 December 2020

Efficacy and safety of the angiotensin II receptor blocker losartan for hypertrophic cardiomyopathy: the INHERIT randomised, double-blind, placebo-controlled trial

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Correlation of molecular and functional effects of mutations in cardiac troponin T linked to familial hypertrophic cardiomyopathy: an integrative in silico/in vitro approach

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Novel insights on the relationship between T-tubular defects and contractile dysfunction in a mouse model of hypertrophic cardiomyopathy.

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12 December 2020

Pharmacological treatment options for hypertrophic cardiomyopathy: high time for evidence

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12 December 2020

Ca(2+) activation of myofilaments from transgenic mouse hearts expressing R92Q mutant cardiac troponin T

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12 December 2020

Nav1.5-dependent persistent Na+ influx activates CaMKII in rat ventricular myocytes and N1325S mice

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12 December 2020

Inhibition of the late sodium current slows t-tubule disruption during the progression of hypertensive heart disease in the rat.

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12 December 2020

Temporal and mutation-specific alterations in Ca2+ homeostasis differentially determine the progression of cTnT-related cardiomyopathies in murine models

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12 December 2020

Clinical phenotype and outcome of hypertrophic cardiomyopathy associated with thin-filament gene mutations

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12 December 2020

Action potential propagation in transverse-axial tubular system is impaired in heart failure.

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12 December 2020

Mechanical and energetic consequences of HCM-causing mutations

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12 December 2020

Sudden death due to troponin T mutations

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12 December 2020

Impact of detubulation on force and kinetics of cardiac muscle contraction.

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12 December 2020

Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.

1 reference

12 December 2020

Ranolazine improves cardiac diastolic dysfunction through modulation of myofilament calcium sensitivity

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12 December 2020

Antifibrotic effects of antioxidant N-acetylcysteine in a mouse model of human hypertrophic cardiomyopathy mutation

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12 December 2020

Cardiac troponin T mutations result in allele-specific phenotypes in a mouse model for hypertrophic cardiomyopathy

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12 December 2020

Murine echocardiography and ultrasound imaging

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12 December 2020

Phenotyping of left and right ventricular function in mouse models of compensated hypertrophy and heart failure with cardiac MRI

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12 December 2020

R4496C RyR2 mutation impairs atrial and ventricular contractility

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12 December 2020

Diltiazem treatment for pre-clinical hypertrophic cardiomyopathy sarcomere mutation carriers: a pilot randomized trial to modify disease expression

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The pathogenesis of cardiac fibrosis.

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12 December 2020

2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy: the Task Force for the Diagnosis and Management of Hypertrophic Cardiomyopathy of the European Society of Cardiology (ESC).

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12 December 2020

Ca²⁺-calmodulin-dependent protein kinase II regulation of cardiac excitation-transcription coupling

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12 December 2020

Research priorities in hypertrophic cardiomyopathy: report of a Working Group of the National Heart, Lung, and Blood Institute.

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12 December 2020

Decreased energetics in murine hearts bearing the R92Q mutation in cardiac troponin T

1 reference

12 December 2020

Intracellular Na+ overload causes oxidation of CaMKII and leads to Ca2+ mishandling in isolated ventricular myocytes

1 reference

12 December 2020

Use-dependent block of cardiac late Na(+) current by ranolazine

1 reference

12 December 2020

The cardiac-specific nuclear delta(B) isoform of Ca2+/calmodulin-dependent protein kinase II induces hypertrophy and dilated cardiomyopathy associated with increased protein phosphatase 2A activity

1 reference

12 December 2020

10.1161/CIRCHEARTFAILURE.116.003565

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28255011%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28255011%20AND%20SRC:MED&resulttype=core&format=json

14 June 2020

1 reference