(Q50989823)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528867%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

title

A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528867%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528867%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Ruibin Xi

25

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528867%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Gordon B. Mills

40

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528867%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

30

Toni K Choueiri

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528867%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

author name string

Yiqun Zhang

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528867%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Patrick Kwok-Shing Ng

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528867%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Melanie Kucherlapati

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528867%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Fengju Chen

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528867%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Yuexin Liu

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528867%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Yiu Huen Tsang

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528867%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Guillermo de Velasco

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528867%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Kang Jin Jeong

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528867%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Rehan Akbani

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528867%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Angela Hadjipanayis

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528867%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Angeliki Pantazi

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528867%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Christopher A Bristow

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528867%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Eunjung Lee

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528867%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Harshad S Mahadeshwar

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528867%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Jiabin Tang

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528867%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Jianhua Zhang

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528867%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Lixing Yang

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528867%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Semin Lee

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528867%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Xiaojia Ren

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528867%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Xingzhi Song

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528867%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Huandong Sun

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528867%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Jonathan Seidman

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528867%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Lovelace J Luquette

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528867%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Alexei Protopopov

27

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528867%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Thomas F Westbrook

28

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528867%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Carl Simon Shelley

29

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528867%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Michael Ittmann

31

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528867%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Carter Van Waes

32

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528867%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

John N Weinstein

33

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528867%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Han Liang

34

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528867%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Elizabeth P Henske

35

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528867%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Andrew K Godwin

36

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528867%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Peter J Park

37

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528867%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Raju Kucherlapati

38

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528867%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Kenneth L Scott

39

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528867%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

David J Kwiatkowski

41

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528867%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Chad J Creighton

42

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528867%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

Lynda Chin

26

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528867%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

publication date

18 May 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528867%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528867%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

volume

31

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528867%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528867%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

page(s)

820-832.e3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528867%20AND%20SRC:MED&resulttype=core&format=json

Characterization of Human Cancer Cell Lines by Reverse-phase Protein Arrays

20 March 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5502825

Emerging role of mTOR in the response to cancer therapeutics

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5502825

The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5502825

pVHL suppresses kinase activity of Akt in a proline-hydroxylation-dependent manner

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5502825

Identification of Variant-Specific Functions of PIK3CA by Rapid Phenotyping of Rare Mutations

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5502825

Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5502825

The PI3K/AKT Pathway as a Target for Cancer Treatment

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5502825

Reverse phase protein arrays in signaling pathways: a data integration perspective

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5502825

Rapamycin Enhances the Anti-Cancer Effect of Dasatinib by Suppressing Src/PI3K/mTOR Pathway in NSCLC Cells

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5502825

PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5502825

Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5502825

mTORC1 drives HIF-1α and VEGF-A signalling via multiple mechanisms involving 4E-BP1, S6K1 and STAT3

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5502825

LINCS Canvas Browser: interactive web app to query, browse and interrogate LINCS L1000 gene expression signatures

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5502825

A pan-cancer proteomic perspective on The Cancer Genome Atlas.

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5502825

A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity.

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5502825

Discovery and saturation analysis of cancer genes across 21 tumour types

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5502825

mTOR target NDRG1 confers MGMT-dependent resistance to alkylating chemotherapy

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5502825

Mutational landscape and significance across 12 major cancer types

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5502825

Pan-cancer patterns of somatic copy number alteration

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5502825

Comprehensive molecular characterization of clear cell renal cell carcinoma

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5502825

Signal integration by mTORC1 coordinates nutrient input with biosynthetic output.

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5502825

Diverse mechanisms of somatic structural variations in human cancer genomes

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5502825

Comprehensive molecular portraits of human breast tumours

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5502825

The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5502825

mTOR signaling in growth control and disease

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5502825

Systematic identification of genomic markers of drug sensitivity in cancer cells

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5502825

High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5502825

Predicting the functional impact of protein mutations: application to cancer genomics

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5502825

Proteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogen-receptor (ER) levels and activity in ER+ breast cancer

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5502825

The role of VHL in clear-cell renal cell carcinoma and its relation to targeted therapy

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5502825

A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5502825

The role of PTEN signaling perturbations in cancer and in targeted therapy

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5502825

Multiple oncogenic pathway signatures show coordinate expression patterns in human prostate tumors

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5502825

A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5502825

AKT/PKB signaling: navigating downstream

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5502825

The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5502825

Exploiting the PI3K/AKT pathway for cancer drug discovery

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5502825

High frequency of mutations of the PIK3CA gene in human cancers

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5502825

Statistical significance for genomewide studies

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5502825

16 June 2018

The Hallmarks of Cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5502825

Human cathelicidin LL-37 inhibits platelet aggregation and thrombosis via Src/PI3K/Akt signaling.

16 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5502825

Mutant IDH1 promotes leukemogenesis in vivo and can be specifically targeted in human AML.

14 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5502825

Mutation of the 9q34 gene TSC1 in sporadic bladder cancer

14 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28528867

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CCELL.2017.04.013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528867%20AND%20SRC:MED&resulttype=core&format=json

release_so7ls7dgsbhupphgihbjz6vgfe

20 March 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/so7ls7dgsbhupphgihbjz6vgfe

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28528867%20AND%20SRC:MED&resulttype=core&format=json

20 March 2020

1 reference