(Q51019605)

27 March 2018

title

Synthesis, binding affinity and structure-activity relationships of novel, selective and dual targeting CCR2 and CCR5 receptor antagonists. (English)

1 reference

27 March 2018

author

Junichiro Yamaguchi

6

1 reference

27 March 2018

Laura H Heitman

object named as

Laura H Heitman

14

0 references

Michael Koch

12

object named as

Michael Koch

1 reference

27 March 2018

author name string

Anna Junker

1

1 reference

27 March 2018

Artur K Kokornaczyk

2

1 reference

27 March 2018

Annelien J M Zweemer

3

1 reference

27 March 2018

Bastian Frehland

4

1 reference

27 March 2018

Dirk Schepmann

5

1 reference

27 March 2018

Kenichiro Itami

7

1 reference

27 March 2018

Andreas Faust

8

1 reference

27 March 2018

Sven Hermann

9

1 reference

27 March 2018

Stefan Wagner

10

1 reference

27 March 2018

Michael Schäfers

11

1 reference

27 March 2018

Christina Weiss

13

1 reference

27 March 2018

Klaus Kopka

15

1 reference

27 March 2018

Bernhard Wünsch

16

1 reference

27 March 2018

publication date

1 February 2015

1 reference

27 March 2018

Organic and Biomolecular Chemistry

published in

1 reference

27 March 2018

volume

13

1 reference

27 March 2018

issue

8

1 reference

27 March 2018

page(s)

2407-2422

1 reference

27 March 2018

Chemokines, chemokine receptors and small-molecule antagonists: recent developments

cites work

1 reference

https://api.crossref.org/works/10.1039%2FC4OB02397H

Functional differences between monocyte chemotactic protein-1 receptor A and monocyte chemotactic protein-1 receptor B expressed in a Jurkat T cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4OB02397H

The CC chemokine eotaxin (CCL11) is a partial agonist of CC chemokine receptor 2b.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4OB02397H

Regulation of eotaxin-3/CCL26 expression in human monocytic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4OB02397H

CC and CXC chemokine receptors mediate migration, proliferation, and matrix metalloproteinase production by fibroblast-like synoviocytes from rheumatoid arthritis patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4OB02397H

CCR2 expressing CD4+ T lymphocytes are preferentially recruited to the ileum in Crohn's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4OB02397H

Monocytes are potent facilitators of alveolar neutrophil emigration during lung inflammation: role of the CCL2-CCR2 axis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4OB02397H

CCR2 antagonist CCX140-B provides renal and glycemic benefits in diabetic transgenic human CCR2 knockin mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4OB02397H

Experimental evidence for the use of CCR2 antagonists in the treatment of type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4OB02397H

Chemokine blockers--therapeutics in the making?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4OB02397H

Identification of a major co-receptor for primary isolates of HIV-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4OB02397H

Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4OB02397H

Effects of the CCR5-Delta32 mutation on antiviral treatment in chronic hepatitis C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4OB02397H

Genetic association of the CCR5 region with lipid levels in at-risk cardiovascular patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4OB02397H

Chemokines: key regulators of mononuclear cell recruitment in atherosclerotic vascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4OB02397H

Molecular cloning and functional expression of a new human CC-chemokine receptor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4OB02397H

Regulation of the migration and survival of monocyte subsets by chemokine receptors and its relevance to atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4OB02397H

Dual targeting of CCR2 and CCR5: therapeutic potential for immunologic and cardiovascular diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4OB02397H

Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4OB02397H

Safety, efficacy, and pharmacokinetics of TBR-652, a CCR5/CCR2 antagonist, in HIV-1-infected, treatment-experienced, CCR5 antagonist-naive subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4OB02397H

Discovery of novel, potent, and selective small-molecule CCR5 antagonists as anti-HIV-1 agents: synthesis and biological evaluation of anilide derivatives with a quaternary ammonium moiety

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4OB02397H

Highly potent and orally active CCR5 antagonists as anti-HIV-1 agents: synthesis and biological activities of 1-benzazocine derivatives containing a sulfoxide moiety

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4OB02397H

Diverse modifications of the 4-methylphenyl moiety of TAK-779 by late-stage Suzuki-Miyaura cross-coupling

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4OB02397H

Synthesis of thiophene-based TAK-779 analogues by C-H arylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4OB02397H

Multiple binding sites for small-molecule antagonists at the CC chemokine receptor 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4OB02397H

Molecular mimicry of a CCR5 binding-domain in the microbial activation of dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4OB02397H

Structural and molecular interactions of CCR5 inhibitors with CCR5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4OB02397H

Structural insights from binding poses of CCR2 and CCR5 with clinically important antagonists: a combined in silico study

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4OB02397H

Discovery and pharmacological characterization of a novel rodent-active CCR2 antagonist, INCB3344.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4OB02397H

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4OB02397H

Pharmacophore identification for sigma-1 (sigma1) receptor binding: application of the "deconstruction-reconstruction-elaboration" approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4OB02397H

Structural features important for sigma 1 receptor binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4OB02397H

Pharmacophore models and development of spirocyclic ligands for σ1 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4OB02397H

Novel sigma receptor ligands. Part 2. SAR of spiro[[2]benzopyran-1,4'-piperidines] and spiro[[2]benzofuran-1,4'-piperidines] with carbon substituents in position 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4OB02397H

Improvement of σ1 receptor affinity by late-stage C-H-bond arylation of spirocyclic lactones

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC4OB02397H

21 January 2018

Identifiers

DOI

10.1039/C4OB02397H

1 reference

27 March 2018

PubMed ID

25566983

1 reference

27 March 2018